Gene Overview
Target Gene: TIMP3
NCBI Official Symbol: TIMP3
Entrez ID: 7078
Ensembl ID: ENSG00000100234
Gene Full Name: TIMP metallopeptidase inhibitor 3
Strand: +
Gene Locus: 22q12.3
External Links:

TIMP3 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate TIMP3   
T(co)Fs that Repress TIMP3
The Intensity of the Gene Regulated by T(co)Fs:
TIMP3-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
TIMP3 FOXO1 shRNA Bone EWS-FLI1 2.38042 1.25122 0.00517 0.13035 DataSet_01_106
TIMP3 SPDEF shRNA Mammary_gland MCF7 0.46758 -1.09673 0.6349 0.99999 DataSet_01_107
TIMP3 ID1 siRNA Lung A549 1.86546 0.89953 0.10787 0.32388 DataSet_01_117
TIMP3 ID1 siRNA Lung H1650 2.27026 1.18285 0.06489 0.39129 DataSet_01_118
TIMP3 FOXM1 siRNA Central_nervous_system U87 4.57439 2.19358 - - DataSet_01_122
TIMP3 ZNF100 siRNA Gastrointestinal_tissue GIST-T1 0.64469 -0.63331 0.00033 0.01243 DataSet_01_124
TIMP3 ZNF254 siRNA Gastrointestinal_tissue GIST-T1 0.62697 -0.67352 0.00021 0.00511 DataSet_01_127
TIMP3 ZNF665 siRNA Gastrointestinal_tissue GIST-T1 0.64253 -0.63817 0.00031 0.00806 DataSet_01_129
TIMP3 ZNF708 siRNA Gastrointestinal_tissue GIST-T1 0.58646 -0.7699 7.50661e-05 0.00424 DataSet_01_130
TIMP3 EGR4 siRNA Lung SBC-5 0.61037 -0.71225 0.05499 0.35617 DataSet_01_132
TIMP3 SPDEF shRNA Mammary_gland MCF7 1.85874 0.89433 0.00011 0.01477 DataSet_01_135
TIMP3 POLR3A siRNA Mammary_gland MCF7 0.31984 -1.64457 - - DataSet_01_139
TIMP3 ZFX shRNA Haematopoietic_and_lymphoid_tissue NOMO-1 0.57857 -0.78943 0.07704 0.99999 DataSet_01_144
TIMP3 SF1 siRNA Adrenal_gland H295R/TR 0.57465 -0.79924 5.57601e-05 0.00171 DataSet_01_146
TIMP3 TFAP2C shRNA Mammary_gland MCF7 1.52387 0.60774 4.81338e-06 2.30469e-05 DataSet_01_150
TIMP3 LIN28B siRNA Embryo_kidney HEK293 0.64912 -0.62343 0.00156 0.0226 DataSet_01_153
TIMP3 GATA3 siRNA Peripheral_blood CD4+ T cells 0.60132 -0.7338 0.05055 0.35872 DataSet_01_163
TIMP3 STAT3 siRNA Peripheral_blood CD4+ T cells 0.6212 -0.68687 0.03461 0.99183 DataSet_01_168
TIMP3 JUN siRNA Mammary_gland BT549 1.69786 0.76372 0.00068 0.04371 DataSet_01_172
TIMP3 ESRRG siRNA Placenta_tissue Trophoblast cells 0.58399 -0.77599 0.04629 0.30929 DataSet_01_173
TIMP3 TP53 siRNA Lung SAECs 2.08406 1.0594 0.00096 0.12822 DataSet_01_175
TIMP3 TP63 shRNA Bladder UC14 0.47341 -1.07883 6.07459e-06 0.00022 DataSet_01_183
TIMP3 STAT3 siRNA Urothelial Scaber 1.50739 0.59205 3.93568e-05 0.00127 DataSet_01_184
TIMP3 TCF4 siRNA Autonomic_ganglia SH-SY5Y 0.46882 -1.0929 2.22557e-05 0.0053 DataSet_01_185
TIMP3 GATA2 siRNA Prostate LNCaP 0.22742 -2.13659 4.96157e-05 0.00063 DataSet_01_193
TIMP3 CREB1 shRNA Parotid_gland H3118 MEC 0.65156 -0.61802 0.0804 0.39013 DataSet_01_194
TIMP3 TP63 siRNA Head_and_neck SCC-1 0.47968 -1.05984 - - DataSet_01_198
TIMP3 XBP1 shRNA Mammary_gland MDA-MB-231 1.61565 0.69212 0.00023 0.00823 DataSet_01_204
TIMP3 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly1 1.80734 0.85386 - - DataSet_01_209
TIMP3 REST siRNA Prostate LNCaP 0.65266 -0.6156 0.26765 0.57302 DataSet_01_211
TIMP3 LIN28A siRNA Embryo H9 8.36659 3.06464 8.18875e-07 0.00024 DataSet_01_215
TIMP3 TAL1 shRNA Haematopoietic_and_lymphoid_tissue HEL 1.63445 0.7088 0.00531 0.03541 DataSet_01_217
TIMP3 PTEN shRNA Mammary_gland MCF10A 1.85081 0.88816 1.39808e-06 4.20877e-05 DataSet_01_218
TIMP3 NFYB siRNA Bone_marrow U2OS ER-HA-E2F1 0.65847 -0.60281 0.00064 0.01848 DataSet_01_238
TIMP3 TWIST1 shRNA Stomach CAF14 0.18203 -2.45772 0.00068 0.99996 DataSet_01_252
TIMP3 TWIST1 shRNA Stomach CAF32 0.38625 -1.3724 0.00099 0.01949 DataSet_01_253
TIMP3 TWIST1 shRNA Stomach CAF 0.26516 -1.91506 0.2133 0.68456 DataSet_01_254
TIMP3 YBX1 shRNA Mammary_gland MDA 0.47929 -1.06102 8.61331e-05 0.00168 DataSet_01_257
TIMP3 YBX1 shRNA Mammary_gland MDA 1.53219 0.6156 0.06328 0.26359 DataSet_01_258
TIMP3 YBX1 shRNA Mammary_gland MDA 0.60282 -0.7302 7.88043e-05 0.00067 DataSet_01_259
TIMP3 ZIC5 siRNA Skin SK-MEL-28 1.54397 0.62665 - - DataSet_01_285
TIMP3 JUN siRNA Mammary_gland BT549 0.60593 -0.72278 0.094 0.26886 DataSet_01_291
TIMP3 POSTN shRNA Brain GSC272 2.60557 1.3816 0.0587 0.53976 DataSet_01_293
TIMP3 TFAP4 siRNA Brain BE(2)-C 0.13512 -2.88769 0.26468 0.51625 DataSet_01_295
TIMP3 SOX17 siRNA Umbilical_vein HUVEC 2.01707 1.01226 0.22671 0.99998 DataSet_01_300
TIMP3 PTEN shRNA Skin A431 1.77278 0.82602 0.01187 0.10137 DataSet_01_301
TIMP3 PTEN shRNA Lung HCC827 1.58353 0.66314 0.11215 0.6177 DataSet_01_302
TIMP3 PTEN shRNA Mammary_gland SKBR3 0.55256 -0.85579 0.62297 0.87336 DataSet_01_303
TIMP3 ETV5 siRNA Soft_tissue hADSC 2.18881 1.13015 9.05341e-05 0.00489 DataSet_01_304
TIMP3 NR2E1 shRNA Neuroepithelium PBT003 0.5647 -0.82445 0.02878 0.45072 DataSet_01_306
TIMP3 TFAP2C siRNA Lung NCI-H292 0.62797 -0.67124 - - DataSet_01_312
TIMP3 OVOL2 siRNA Corneal_epithelial Corneal epithelial cells 1.72174 0.78387 0.01329 0.25306 DataSet_01_313
TIMP3 ARNT siRNA Upper_aerodigestive_tract HSC3 0.44586 -1.16535 - - DataSet_01_315
TIMP3 ERG siRNA Cervix HeLa 0.58836 -0.76522 7.85644e-13 2.37701e-11 DataSet_01_316
TIMP3 ELK3 shRNA Mammary_gland MDA-MB-231 2.4134 1.27107 0.13791 0.199 DataSet_01_318
TIMP3 KLF7 siRNA Embryo HCE 1.55361 0.63563 0.06146 0.99985 DataSet_01_342
TIMP3 SOX17 siRNA Umbilical_vein HUVEC 2.09251 1.06523 - - DataSet_01_360
TIMP3 GTF2B siRNA Cervix HeLa 1.78978 0.83978 - - DataSet_01_362
TIMP3 U2AF2 shRNA Liver HepG2 1.84785 0.88584 0.00798 0.06477 DataSet_02_105
TIMP3 SSB shRNA Liver HepG2 0.23409 -2.09485 6.98997e-05 0.00366 DataSet_02_107
TIMP3 HNRNPUL1 shRNA Liver HepG2 0.6142 -0.70321 0.00302 0.0254 DataSet_02_109
TIMP3 BCLAF1 shRNA Liver HepG2 2.45366 1.29494 0.00032 0.02378 DataSet_02_112
TIMP3 U2AF2 shRNA Liver HepG2 1.9634 0.97336 0.00202 0.0514 DataSet_02_113
TIMP3 SUB1 shRNA Liver HepG2 1.76635 0.82077 0.00335 0.12645 DataSet_02_117
TIMP3 PTBP1 shRNA Liver HepG2 0.56074 -0.83459 6e-04 0.00619 DataSet_02_120
TIMP3 HNRNPLL shRNA Liver HepG2 1.72146 0.78364 0.00275 0.01774 DataSet_02_125
TIMP3 TARDBP shRNA Haematopoietic_and_lymphoid_tissue K562 0.65789 -0.60407 0.01179 0.26467 DataSet_02_129
TIMP3 PTBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.26316 -1.926 0.00654 0.03889 DataSet_02_131
TIMP3 SRSF7 shRNA Haematopoietic_and_lymphoid_tissue K562 0.60526 -0.72437 0.27888 0.52495 DataSet_02_133
TIMP3 PCBP2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.52632 -0.926 0.04887 0.16211 DataSet_02_135
TIMP3 HNRNPK shRNA Haematopoietic_and_lymphoid_tissue K562 0.63158 -0.66297 0.08867 0.2773 DataSet_02_136
TIMP3 PCBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.44737 -1.16046 0.02434 0.22694 DataSet_02_137
TIMP3 RBFOX2 shRNA Haematopoietic_and_lymphoid_tissue K562 1.58824 0.66742 0.07839 0.48912 DataSet_02_139
TIMP3 TAF15 shRNA Haematopoietic_and_lymphoid_tissue K562 1.72222 0.78427 0.00236 0.13508 DataSet_02_140
TIMP3 BCLAF1 shRNA Haematopoietic_and_lymphoid_tissue K562 1.57576 0.65605 0.00352 0.08937 DataSet_02_142
TIMP3 PTBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.6 -0.73697 0.49434 0.69015 DataSet_02_144
TIMP3 CCAR2 shRNA Haematopoietic_and_lymphoid_tissue K562 1.52941 0.61298 0.09831 0.52463 DataSet_02_146
TIMP3 FIP1L1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.46552 -1.10309 0.10203 0.2253 DataSet_02_147
TIMP3 ILF3 shRNA Haematopoietic_and_lymphoid_tissue K562 2.02941 1.02106 0.02767 0.27889 DataSet_02_148
TIMP3 NONO shRNA Haematopoietic_and_lymphoid_tissue K562 1.55 0.63227 0.02304 0.20045 DataSet_02_149
TIMP3 SAFB2 shRNA Haematopoietic_and_lymphoid_tissue K562 1.61702 0.69334 0.00666 0.41496 DataSet_02_150
TIMP3 ILF2 shRNA Haematopoietic_and_lymphoid_tissue K562 1.56757 0.64853 0.04954 0.31754 DataSet_02_152
TIMP3 FUS shRNA Haematopoietic_and_lymphoid_tissue K562 0.1875 -2.41504 0.00624 0.22733 DataSet_02_155
TIMP3 HNRNPL shRNA Haematopoietic_and_lymphoid_tissue K562 1.57971 0.65966 0.02613 0.151 DataSet_02_160
TIMP3 TAF15 shRNA Haematopoietic_and_lymphoid_tissue K562 4.75 2.24793 0.17107 0.41111 DataSet_02_163
TIMP3 TARDBP shRNA Haematopoietic_and_lymphoid_tissue K562 0.4 -1.32193 0.18442 0.28035 DataSet_02_169
TIMP3 RBM15 shRNA Haematopoietic_and_lymphoid_tissue K562 0.30556 -1.71049 0.12421 0.32247 DataSet_02_171
TIMP3 ZFX siRNA Prostate C4-2B 0.375 -1.41504 0.41261 0.52979 DataSet_02_172
TIMP3 TBL1XR1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.60526 -0.72437 0.5091 1 DataSet_02_178
TIMP3 RAD21 siRNA Haematopoietic_and_lymphoid_tissue K562 0.58974 -0.76184 0.27023 1 DataSet_02_190
TIMP3 LMNB2 siRNA Haematopoietic_and_lymphoid_tissue K562 0.40741 -1.29546 0.17501 1 DataSet_02_191
TIMP3 CHD2 siRNA Haematopoietic_and_lymphoid_tissue K562 2.09091 1.06413 0.00785 0.12618 DataSet_02_196
TIMP3 E2F4 siRNA Haematopoietic_and_lymphoid_tissue K562 0.59259 -0.75489 0.11868 1 DataSet_02_200
TIMP3 ARID1A siRNA Mammary_gland MDA-MB-157 0.492897 -1.02064 - - DataSet_03_014
TIMP3 ATF4 siRNA Skin A375 0.525502 -0.928232 0.147134554889291 0.775512819201899 DataSet_03_018
TIMP3 BCL6 siRNA Lymph OCI-Ly7 DLBCL 0.661772 -0.595595 0.133481408582784 0.780526805601834 DataSet_03_025
TIMP3 CEBPB siRNA Embryo hESC 0.254833 -1.97238 0.00507640192479535 0.18474937318422 DataSet_03_049
TIMP3 CREBBP siRNA Mammary_gland MCF7 0.519323 -0.945295 0.00576782602928664 0.963067261754673 DataSet_03_055
TIMP3 ESR1 siRNA Uterus Endometrial stromal cells 0.474497 -1.07553 - - DataSet_03_069
TIMP3 ESR1 siRNA Uterus Endometrial stromal cells 0.479853 -1.05933 0.00713585734356002 1 DataSet_03_070
TIMP3 FOXO1 siRNA Skin primary human dermal lymphatic endothelial cells 1.56154 0.642971 - - DataSet_03_096
TIMP3 GATA2 siRNA Uterus Decidual stromal cells 0.472073 -1.08292 0.718406845134931 0.971971535715284 DataSet_03_100
TIMP3 GATA3 siRNA Mammary_gland MCF7 1.53943 0.622395 0.0347961703928669 0.999831535534034 DataSet_03_102
TIMP3 MAFB siRNA Peripheral_blood Monocyte-derived M-CSF macrophages 0.652176 -0.616667 0.366998042185737 1 DataSet_03_155
TIMP3 MITF siRNA Skin MZ7 3.13281 1.64746 1.93176858969892e-13 2.41081940471275e-11 DataSet_03_165
TIMP3 MITF siRNA Skin Ma-Mel-15 2.00174 1.00126 0.0288026810952018 0.248643553127967 DataSet_03_167
TIMP3 MITF siRNA Skin SK-MEL-5 0.507501 -0.978517 2.47000893248187e-05 0.000185401577064455 DataSet_03_168
TIMP3 MYC siRNA Central_nervous_system DAOY M2.1 2.32365 1.21639 5.50459539150099e-09 3.0204502206279e-07 DataSet_03_178
TIMP3 MYCN siRNA Brain BE(2)C cells 2.49614 1.3197 - - DataSet_03_188
TIMP3 NFAT5 siRNA Synovial Primary fibroblast-like synoviocytes 0.379693 -1.39709 0.0609200532832296 0.36710761974231 DataSet_03_194
TIMP3 PBX1 siRNA Mammary_gland MCF7 0.646807 -0.628594 0.00138454019435882 0.594092034958176 DataSet_03_207
TIMP3 PBX1 siRNA Mammary_gland MCF7 0.457491 -1.12818 3.32944980675682e-06 0.0013099771922144 DataSet_03_209
TIMP3 PHB shRNA Embryo Embryonic stem cells (ESCs) 5.62959 2.49303 2.30792065333176e-05 0.000552243334230931 DataSet_03_211
TIMP3 PPARG siRNA Peripheral_blood GM-CSF Macrophage 1.99078 0.993333 0.00878248379808726 0.771788785531601 DataSet_03_214
TIMP3 PRRX1 siRNA Skin Fibroblast 1.64214 0.715573 0.0163154768433128 0.267088118650125 DataSet_03_216
TIMP3 RELB siRNA Immortalized_keratinocyte HaCaT 4.50101 2.17025 1.90147485288564e-08 1.07768513116317e-06 DataSet_03_227
TIMP3 SOX11 siRNA Lung_fibroblast NHLF 2.19268 1.13269 0.0690995622761923 0.432905590969631 DataSet_03_237
TIMP3 SOX2 siRNA Embryo 2102Ep 2.17761 1.12274 1.04341317838522e-06 0.000125214959824672 DataSet_03_242
TIMP3 SOX2 siRNA Mammary_gland GSC-11 2.2268 1.15497 0.0015027035028389 0.0262698765074254 DataSet_03_245
TIMP3 SOX4 siRNA Mammary_gland MDA-LM2 1.52017 0.604233 0.00817365509171755 0.338397123809127 DataSet_03_247
TIMP3 SSRP1 siRNA Brain BE(2)C cells 2.23942 1.16313 0.000376261044292663 0.0972070407930096 DataSet_03_255
TIMP3 STAT6 siRNA Umbilical_vein HUVEC 1.57525 0.655582 0.246754744770064 0.863148031458458 DataSet_03_264
TIMP3 TBX3 siRNA Skin Fibroblast 0.661244 -0.596746 0.00099406344320316 0.0231626823311217 DataSet_03_265
TIMP3 TET2 siRNA Embryo NCCIT 1.58698 0.666282 8.79726285614603e-05 0.00229014007381548 DataSet_03_270
TIMP3 TET3 siRNA Embryo NCCIT 1.55578 0.637635 0.000245016835572843 0.00696415534962959 DataSet_03_273
TIMP3 TFAP2C siRNA Mammary_gland MCF7 0.417351 -1.26067 0.0310919137736502 0.342672706982259 DataSet_03_274
TIMP3 TFE3 siRNA Kidney UOK257-2 1.89024 0.91857 - - DataSet_03_275
TIMP3 TWIST1 siRNA Bone_marrow MSCs 1.57125 0.651916 - - DataSet_03_283
TIMP3 TWIST2 siRNA Skin Fibroblast 0.652854 -0.615168 0.000384215879884145 0.0315787122939458 DataSet_03_284
TIMP3 ZNF554 siRNA Embryo HTR8/Svneo 1.69824 0.764036 2.98016109590094e-07 0.000143560982569762 DataSet_03_292
TIMP3 CIZ1 CRISPR Haematopoietic_and_lymphoid_tissue K562 3.30189 1.72329 0.00249766152487 0.0232853659431225 DataSet_04_004
TIMP3 EIF2AK2 CRISPR Haematopoietic_and_lymphoid_tissue K562 2.3 1.20163 0.000459813322545574 0.31877284568794 DataSet_04_008
TIMP3 NKRF shRNA Haematopoietic_and_lymphoid_tissue K562 433.5 8.75989 0.00417633459895514 0.0287592565107943 DataSet_04_014
TIMP3 PAN2 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.315789 -1.66297 0.00690687378367358 0.726311322174992 DataSet_04_016
TIMP3 XRCC5 CRISPR Haematopoietic_and_lymphoid_tissue K562 1.62264 0.698344 0.0349140448836271 0.231996414072286 DataSet_04_021
TIMP3 NFX1 CRISPR Liver HepG2 0.524908 -0.929864 0.00102201833252778 0.0138025146943203 DataSet_04_032
TIMP3 ABT1 shRNA Liver HepG2 0.435528 -1.19916 8.13265790830186e-05 0.00234413953480806 DataSet_04_052
TIMP3 CCAR1 shRNA Liver HepG2 0.622985 -0.68273 0.00151770245297217 0.0196043373903833 DataSet_04_054
TIMP3 CNOT7 shRNA Liver HepG2 0.388716 -1.36321 3.5437304502073e-05 0.00198150036378459 DataSet_04_051
TIMP3 YBX3 shRNA Liver HepG2 2.41524 1.27217 2.40281782364982e-05 0.0254975937517303 DataSet_02_98
TIMP3 RIOK2 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.636364 -0.652077 0.239248018129224 0.727088888995072 DataSet_04_076
TIMP3 HMGA1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.64 -0.643856 0.742368606266672 0.926538332634085 DataSet_02_75
TIMP3 LDB1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 1.5625 0.643856 0.502373134621256 0.678405698976659 DataSet_02_35
TIMP3 SNW1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 1.75 0.807355 0.874355243083871 0.989454336211367 DataSet_02_49
TIMP3 TBL1XR1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.625 -0.678072 0.652554711047769 0.80449721115013 DataSet_02_43
TIMP3 TEAD2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.625 -0.678072 0.59729312450115 0.743476631050422 DataSet_02_33
TIMP3 TLE2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 1.75 0.807355 0.293070968050123 0.462574139823023 DataSet_02_53
TIMP3 ABT1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.54386 -0.878694 0.128518720251295 0.255748891868859 DataSet_04_060
TIMP3 CCAR1 shRNA Haematopoietic_and_lymphoid_tissue K562 1.88235 0.912537 0.156110735165136 0.320334537817775 DataSet_04_064
TIMP3 DDX1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.529412 -0.917538 0.473506435356401 0.825767935398884 DataSet_04_063
TIMP3 PRPF6 shRNA Haematopoietic_and_lymphoid_tissue K562 0.509434 -0.973033 0.145320885508543 0.50860454925622 DataSet_04_065
TIMP3 PATZ1 siRNA Liver HepG2 0.586015 -0.77099 1.289898e-05 3.242700e-03 DataSet_03_296
TIMP3 PATZ1 siRNA Liver HepG2 0.586015 -0.77099 1.289898e-05 3.242700e-03 DataSet_03_297
TIMP3 EZH2 siRNA Uterus Hec-1A 2.16745 1.116 4.754692e-07 2.547793e-04 DataSet_03_314
TIMP3 AEBP1 siRNA Umbilical_vein HUVEC 0.636524 -0.651712 2.102051e-01 0.745325508 DataSet_03_300
TIMP3 ELF3 CRISPR Bile_duct HBDEC2 0.284486 -1.81357 1.871217e-05 4.582555e-04 DataSet_03_304
TIMP3 ELF3 knockdown Bile_duct HBDEC2 1.53919 0.622172 9.905987e-04 2.046609e-02 DataSet_03_305
TIMP3 SNAI2 shRNA Pancreas pancreatic cancer stem cells 0.542613 -0.882003 8.040241e-01 0.9272984 DataSet_03_306
TIMP3 SNAI2 shRNA Pancreas KLM1 0.475853 -1.07141 7.969581e-02 0.37326605 DataSet_03_307
TIMP3 PBX1 siRNA Mammary_gland MCF7 0.457491 -1.12818 4.371050e-06 1.476799e-03 DataSet_03_326
TIMP3 BRCA1 siRNA Mammary_gland MCF7 1.53471 0.617966 1.656287e-02 0.9043344 DataSet_03_308
TIMP3 DNMT1 shRNA Lung hTERT-immortalised adult fibroblasts 1.72681 0.788106 3.239494e-02 4.060007e-01 DataSet_03_311
TIMP3 TET1 CRISPR Mammary_gland MDA-MB-231 0.383051 -1.38439 1.884566e-03 1.973894e-02 DataSet_03_347
TIMP3 EZH2 shRNA Mammary_gland LM2 0.642887 -0.637362 3.952955e-05 1.719793e-02 DataSet_03_350
TIMP3 ESR1 siRNA Mammary_gland MCF7 2.73012 1.44897 1.561778e-05 0.0057786800 DataSet_03_352
TIMP3 TET1 CRISPR Mammary_gland Hs578T 3.83585 1.93955 3.246366e-05 2.659402e-03 DataSet_03_355
TIMP3 PTPN14 CRISPR Brain U5-NPC 0.401522 -1.31645 7.596543e-02 0.30178528 DataSet_03_357
TIMP3 EP300 shRNA Mammary_gland MCF10AT 0.418448 -1.25688 2.549082e-03 0.033443004 DataSet_03_364
TIMP3 ZNF148 shRNA Mammary_gland MDA-MB-231 2.26707 1.18083 2.381257e-04 0.019018067 DataSet_03_366
TIMP3 USP22 shRNA Liver PLC_PRF_5 cells 0.549738 -0.863183 2.303374e-01 0.45255722 DataSet_03_368
TIMP3 DNMT3A knockout Embryo_kidney HEK293T 0.653364 -0.614041 - - DataSet_03_369
TIMP3 E2F1 siRNA Nasopharynx HK1 0.534709 -0.903175 8.967496e-04 1.945507e-02 DataSet_03_373
TIMP3 ZNF213 siRNA Mammary_gland MCF7 0.498556 -1.00417 3.384577e-05 2.822237e-03 DataSet_03_376
TIMP3 EZH2 CRISPR Ovary SKOV3 116 6.85798 1.313830e-02 0.0893677373 DataSet_03_378
TIMP3 NFKB2 siRNA Bone_marrow U2OS 0.303017 -1.72253 6.627990e-04 0.06363566 DataSet_03_381
TIMP3 DNMT1 siRNA Skin Human melanoma cells 1.63239 0.706982 3.168974e-07 1.748697e-05 DataSet_03_382
TIMP3 TCF19 CRISPR Oral_squamous CAL27 1.90863 0.932538 2.130453e-02 0.1232442519 DataSet_03_383
TIMP3 YY1 shRNA Brain GSC1517 0.60396 -0.727474 - - DataSet_03_384
TIMP3 YY1 shRNA Brain GSC23 0.4375 -1.19264 - - DataSet_03_385
TIMP3 YY1 shRNA Brain GSC3028 0.413793 -1.27302 - - DataSet_03_386
TIMP3 TRIM8 siRNA Mammary_gland MCF7 0.21142 -2.24182 1.676386e-06 0.0010836141 DataSet_03_388
TIMP3 NFKBIA shRNA Bone_marrow U2OS 0.625734 -0.676379 3.171719e-04 0.16208955 DataSet_03_389
TIMP3 KDM5A CRISPR Lung GLC16 0.295336 -1.75957 1.922197e-01 0.327976090 DataSet_03_392
TIMP3 ASXL1 CRISPR Embryo iPSC 1.9748 0.981708 0.0338995606 0.8048302 DataSet_03_394
TIMP3 IKZF2 CRISPR Lymph CAR T Cell 0.487696 -1.03595 9.308195e-01 0.999939484 DataSet_03_397
TIMP3 TLE4 CRISPR Lymph CAR T Cell 0.492154 -1.02282 9.381218e-01 0.99302181 DataSet_03_398
TIMP3 RELA CRISPR Brain T30 0.564566 -0.824785 0.0101618883 0.8400824 DataSet_03_399
TIMP3 HMGA1 shRNA Bile_duct HUCCT1 2.14876 1.1035 3.613049e-04 0.023555415 DataSet_03_400
TIMP3 SUMO1 CRISPR Bone_marrow U2OS 0.562791 -0.82933 7.759922e-04 1.194302e-02 DataSet_03_401
TIMP3 JARID2 siRNA Adipose_tissue human adipose tissue derived stem cells 1.61381 0.690475 9.887221e-02 0.3290128 DataSet_03_403
TIMP3 CDK7 shRNA Bone_marrow D458 10.395 3.37782 1.106324e-04 0.03671690 DataSet_03_404
TIMP3 TFAP2A knockout Embryo H9 4.75112 2.24827 1.594316e-03 0.03097278 DataSet_03_405
TIMP3 STRAP knockout Nerve SK-N-AS 6.73466 2.75161 - - DataSet_03_409
TIMP3 USP22 shRNA Liver HuH7 1.7649 0.819584 - - DataSet_03_411
TIMP3 FOXQ1 CRISPR Lymph Primary CD4+ T cells 1.70588 0.770518 - - DataSet_03_422
TIMP3 MAEL CRISPR Liver Alexander cells 13.65 3.77083 - - DataSet_03_423
TIMP3 LHX2 shRNA Bone_marrow ES-derived RPE cells 0.422788 -1.24199 5.179227e-02 1.000000e+00 DataSet_03_428
TIMP3 USP7 shRNA Skin xenograft cells 0.485332 -1.04296 0.27021479 0.4348960 DataSet_03_431
TIMP3 PLAG1 shRNA Cord_blood Lin-CD34+ HSPCs 0.532979 -0.90785 - - DataSet_03_432
TIMP3 NFE2L1 knockout Lung A549 0.573734 -0.801547 2.122882e-01 9.263783e-01 DataSet_03_433
TIMP3 EP300 knockout Pancreas HPAF-II orthotopic cells 0.0756799 -3.72394 1.101838e-08 5.029432e-06 DataSet_03_436
TIMP3 SUFU shRNA Mammary_gland HCC1954 cells 33.5 5.06609 0.0348740118 0.4546061 DataSet_03_437
TIMP3 FOXA2 CRISPR Liver iPSCs-derived progenitors and mature hepatocytes 2.23549 1.16059 2.410193e-02 0.67958964 DataSet_03_439
TIMP3 SETDB1 shRNA Colon HCT116 0.518817 -0.946701 - - DataSet_03_440
TIMP3 PHF14 siRNA Mammary_gland MDA-MB-231 0.61751 -0.695465 0.0098976078 0.2772439 DataSet_03_443
TIMP3 CBX2 siRNA Mammary_gland MCF7 0.324552 -1.62348 1.552220e-01 0.2709136809 DataSet_03_451
TIMP3 ZFP36L1 CRISPR Lung NCI-H1876 1.94274 0.958094 1.807450e-01 0.992381486 DataSet_03_454
TIMP3 SMARCA2 shRNA Lung HCC2302 0.000650128 -10.587 3.421145e-23 4.097438e-19 DataSet_03_455
TIMP3 PPARG siRNA Aortic_valve Valvular endothelial cell 1.98634 0.990113 8.235189e-07 3.768494e-04 DataSet_03_456
TIMP3 SREBF2 siRNA Umbilical_vein HUVEC 0.471651 -1.08421 1.630016e-01 5.972501e-01 DataSet_03_457
TIMP3 ARID1A shRNA Bile_duct MMNK1 0.391008 -1.35473 1.719428e-02 0.133039804 DataSet_03_458
TIMP3 TXNIP shRNA Cord_Blood CD34+ cells 1.61004 0.687097 - - DataSet_03_461
TIMP3 SOX9 knockout Liver HuH7 1.80735 0.853878 7.904752e-04 7.735285e-03 DataSet_03_463
TIMP3 STAT3 shRNA Liver HepG2 1.9226 0.943059 1.455782e-02 0.1843690322 DataSet_03_465
TIMP3 SMARCA1 Cas13 Embryo_kidney HEK293T 0.640921 -0.641781 - - DataSet_03_466
TIMP3 LIN28A siRNA Mammary_gland MCF7M 1.71368 0.777099 7.516978e-01 0.9570847 DataSet_03_469
TIMP3 LIN28A siRNA Mammary_gland MCF7M 1.71368 0.777099 7.516978e-01 0.9570847 DataSet_03_470
Regulation Region
 
T(co)Fs that significantly regulate PBX1 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of TIMP3
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines