Gene Overview
Target Gene: KLF2
NCBI Official Symbol: KLF2
Entrez ID: 10365
Ensembl ID: ENSG00000127528
Gene Full Name: Kruppel like factor 2
Strand: +
Gene Locus: 19p13.11
External Links:

KLF2 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate KLF2   
T(co)Fs that Repress KLF2
The Intensity of the Gene Regulated by T(co)Fs:
KLF2-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
KLF2 IRF6 shRNA Fetal_liver Primary CD34+ hematopoietic stem/progenitor cells (HSPCs) 2.26995 1.18266 9.75507e-05 0.00532 DataSet_01_101
KLF2 MYB shRNA Fetal_liver Primary CD34+ hematopoietic stem/progenitor cells (HSPCs) 2.71878 1.44296 1.66866e-09 9.72133e-08 DataSet_01_102
KLF2 ARID1A shRNA Ovary OSE4 2.44155 1.2878 - - DataSet_01_108
KLF2 ARID1A shRNA Ovary IOSE80pc 2.24326 1.1656 - - DataSet_01_109
KLF2 GATA3 siRNA Mammary_gland MCF7 1.61777 0.69401 0.00638 0.04845 DataSet_01_120
KLF2 ZIC2 siRNA Pancreas PANC1 4.7648 2.25242 - - DataSet_01_121
KLF2 FOXM1 siRNA Central_nervous_system U87 4.91206 2.29633 - - DataSet_01_122
KLF2 SOX4 shRNA Parotid_gland ACC3 2.54764 1.34916 0.01569 0.90222 DataSet_01_140
KLF2 TFAP2C shRNA Mammary_gland MCF7 1.53105 0.61453 0.01066 0.02491 DataSet_01_150
KLF2 ELK1 siRNA Peripheral_blood CD4+ T cells 0.39945 -1.3239 0.03561 0.12521 DataSet_01_162
KLF2 GATA3 siRNA Peripheral_blood CD4+ T cells 492.239 8.94321 0.06538 0.39195 DataSet_01_163
KLF2 JUN siRNA Peripheral_blood CD4+ T cells 0.34458 -1.53711 0.01447 0.08651 DataSet_01_164
KLF2 MAF siRNA Peripheral_blood CD4+ T cells 0.2655 -1.91321 0.00333 0.05421 DataSet_01_165
KLF2 NFATC3 siRNA Peripheral_blood CD4+ T cells 0.24543 -2.02661 0.00241 0.04013 DataSet_01_166
KLF2 STAT3 siRNA Peripheral_blood CD4+ T cells 0.41657 -1.26336 0.04264 0.99183 DataSet_01_168
KLF2 NR4A1 siRNA Pancreas PANC1 1.77358 0.82667 2.41758e-07 0.00012 DataSet_01_174
KLF2 TP53 siRNA Lung SAECs 2.55405 1.35279 0.00157 0.14509 DataSet_01_175
KLF2 HSF1 shRNA Liver KYN2 0.10218 -3.29075 - - DataSet_01_178
KLF2 CREB1 shRNA Parotid_gland HSY 1.51621 0.60047 0.04917 0.58122 DataSet_01_195
KLF2 TP63 siRNA Immortalized_keratinocyte HaCaT RG 1.61572 0.69217 - - DataSet_01_196
KLF2 TP63 siRNA Immortalized_keratinocyte HaCaT 1.72542 0.78694 - - DataSet_01_200
KLF2 HIC1 shRNA Mammary_gland HBL100 1.69803 0.76386 - - DataSet_01_205
KLF2 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly10 0.6269 -0.67369 - - DataSet_01_208
KLF2 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly1 0.43349 -1.20593 - - DataSet_01_209
KLF2 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly7 0.58725 -0.76796 - - DataSet_01_210
KLF2 LIN28A siRNA Embryo H9 0.27291 -1.87349 2.28914e-05 0.00131 DataSet_01_215
KLF2 TAL1 shRNA Haematopoietic_and_lymphoid_tissue HEL 2.41877 1.27428 7.55329e-05 0.00503 DataSet_01_217
KLF2 FOXM1 siRNA Mammary_gland MCF7 2.01209 1.0087 0.00194 0.14615 DataSet_01_223
KLF2 HIF1A shRNA Liver HuH7 1.67518 0.74432 - - DataSet_01_224
KLF2 SNAI2 shRNA Skin Primary human keratinocytes 1.67756 0.74637 0.00542 0.03328 DataSet_01_225
KLF2 KLF2 shRNA Bone_marrow RPMI8226 0.29751 -1.74897 0.00023 0.20283 DataSet_01_226
KLF2 IRX1 shRNA Bone_marrow 143B 0.43211 -1.21053 2.28575e-05 0.00662 DataSet_01_227
KLF2 MYC shRNA Soft_tissue HT1080 0.51405 -0.96001 - - DataSet_01_237
KLF2 TWIST1 shRNA Stomach CAF32 0.23728 -2.07531 6.38024e-05 0.012 DataSet_01_253
KLF2 TWIST1 shRNA Stomach CAF 0.45497 -1.13614 0.03325 0.53167 DataSet_01_254
KLF2 YBX1 shRNA Mammary_gland MDA 0.35653 -1.48791 4.05596e-21 5.44373e-18 DataSet_01_259
KLF2 FOXO3 siRNA Pancreas PANC1 0.47387 -1.07742 - - DataSet_01_267
KLF2 SIX4 siRNA Ovary PEO1 5.89747 2.5601 4.05854e-05 0.00224 DataSet_01_269
KLF2 FOXO1 siRNA Umbilical_vein HUVEC 2.44434 1.28944 3.55853e-05 0.00448 DataSet_01_270
KLF2 MSX1 siRNA Tooth Dental Pulp Cells 6.05998 2.59931 5.26151e-08 2.40258e-05 DataSet_01_281
KLF2 TP53 shRNA Haematopoietic_and_lymphoid_tissue JVM2 0.28965 -1.78763 6.67083e-10 5.71408e-08 DataSet_01_286
KLF2 SNAI2 siRNA Mammary_gland MCFDCIS 2.30133 1.20247 0.00854 0.41535 DataSet_01_292
KLF2 POSTN shRNA Brain GSC272 0.59034 -0.76038 0.20545 0.60269 DataSet_01_293
KLF2 TFAP4 siRNA Brain BE(2)-C 0.20398 -2.29348 0.29666 0.51625 DataSet_01_295
KLF2 MYCN siRNA Brain BE(2)-C 2.60121 1.37918 0.66959 1 DataSet_01_296
KLF2 SOX7 siRNA Umbilical_vein HUVEC 1.55895 0.64058 0.15766 0.89788 DataSet_01_299
KLF2 OVOL2 siRNA Corneal_epithelial Corneal epithelial cells 0.27275 -1.87434 0.13703 0.36806 DataSet_01_313
KLF2 ARNT siRNA Upper_aerodigestive_tract HSC3 0.30679 -1.70466 - - DataSet_01_315
KLF2 ERG siRNA Cervix HeLa 1.96434 0.97404 4.36147e-11 8.75122e-10 DataSet_01_316
KLF2 ELK3 shRNA Mammary_gland MDA-MB-231 0.32735 -1.61111 2.74693e-06 5.94127e-05 DataSet_01_318
KLF2 TOX shRNA Haematopoietic_and_lymphoid_tissue CCRF-CEM 0.61625 -0.69841 0.02468 0.53062 DataSet_01_331
KLF2 HOXC6 siRNA Prostate LNCaP 1.55199 0.63412 0.21017 0.99927 DataSet_01_333
KLF2 ARID1A shRNA Uterus iEEC16 0.57382 -0.80134 - - DataSet_01_345
KLF2 CDX2 siRNA Colon COLO320 1.95321 0.96585 - - DataSet_01_357
KLF2 SOX17 siRNA Umbilical_vein HUVEC 0.62833 -0.67041 - - DataSet_01_360
KLF2 RBM17 shRNA Liver HepG2 0.6087 -0.71621 0.01972 0.26816 DataSet_02_100
KLF2 RBFOX2 shRNA Liver HepG2 0.26087 -1.9386 0.01736 0.65168 DataSet_02_101
KLF2 RBM39 shRNA Liver HepG2 0.08696 -3.52356 0.02056 0.21412 DataSet_02_111
KLF2 TARDBP shRNA Liver HepG2 11.25 3.49185 0.00044 0.0163 DataSet_02_116
KLF2 PTBP1 shRNA Liver HepG2 0.27273 -1.87447 0.02634 0.04635 DataSet_02_120
KLF2 EWSR1 shRNA Liver HepG2 0.17241 -2.53605 0.22312 0.34684 DataSet_02_122
KLF2 SNRNP70 shRNA Liver HepG2 15 3.90689 0.05143 0.1241 DataSet_02_126
KLF2 SRSF3 shRNA Liver HepG2 3.75 1.90689 0.01564 0.09571 DataSet_02_127
KLF2 SRSF9 shRNA Haematopoietic_and_lymphoid_tissue K562 1.77778 0.83007 0.59402 0.70881 DataSet_02_134
KLF2 PCBP2 shRNA Haematopoietic_and_lymphoid_tissue K562 2.11111 1.078 0.05798 0.17596 DataSet_02_135
KLF2 PCBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.55556 -0.848 0.73073 0.86076 DataSet_02_137
KLF2 RBM34 shRNA Haematopoietic_and_lymphoid_tissue K562 1.55556 0.63743 0.44175 0.64289 DataSet_02_141
KLF2 BCLAF1 shRNA Haematopoietic_and_lymphoid_tissue K562 1.72222 0.78427 0.24463 0.42405 DataSet_02_142
KLF2 RBM15 shRNA Haematopoietic_and_lymphoid_tissue K562 0.33333 -1.58496 0.02944 0.06955 DataSet_02_143
KLF2 PTBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 6.75 2.75489 0.12879 0.35048 DataSet_02_144
KLF2 FIP1L1 shRNA Haematopoietic_and_lymphoid_tissue K562 1.77778 0.83007 0.6807 0.78388 DataSet_02_147
KLF2 ILF3 shRNA Haematopoietic_and_lymphoid_tissue K562 0.4375 -1.19265 0.09813 0.3781 DataSet_02_148
KLF2 NONO shRNA Haematopoietic_and_lymphoid_tissue K562 6.75 2.75489 0.0035 0.19424 DataSet_02_149
KLF2 SAFB2 shRNA Haematopoietic_and_lymphoid_tissue K562 2.35294 1.23447 0.01248 0.42628 DataSet_02_150
KLF2 ILF2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.2 -2.32193 0.2729 0.57964 DataSet_02_152
KLF2 YBX3 shRNA Haematopoietic_and_lymphoid_tissue K562 0.14583 -2.77761 0.0019 0.4089 DataSet_02_153
KLF2 SRSF4 shRNA Haematopoietic_and_lymphoid_tissue K562 0.53704 -0.89691 0.77738 0.89878 DataSet_02_154
KLF2 GTF2F1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.57407 -0.80069 0.83823 1 DataSet_02_157
KLF2 PSIP1 shRNA Haematopoietic_and_lymphoid_tissue K562 1.61111 0.68806 0.45337 0.58333 DataSet_02_158
KLF2 XRCC5 shRNA Haematopoietic_and_lymphoid_tissue K562 0.05556 -4.16993 0.2144 0.75398 DataSet_02_159
KLF2 HNRNPL shRNA Haematopoietic_and_lymphoid_tissue K562 0.54054 -0.88753 0.77077 0.86406 DataSet_02_160
KLF2 RBM25 shRNA Haematopoietic_and_lymphoid_tissue K562 0.36364 -1.45943 0.04831 0.23497 DataSet_02_166
KLF2 EWSR1 shRNA Haematopoietic_and_lymphoid_tissue K562 2.3125 1.20945 0.56976 0.74715 DataSet_02_167
KLF2 RBM22 shRNA Haematopoietic_and_lymphoid_tissue K562 3.88889 1.95936 0.45277 0.5802 DataSet_02_168
KLF2 TARDBP shRNA Haematopoietic_and_lymphoid_tissue K562 0.16667 -2.58496 0.10199 0.18334 DataSet_02_169
KLF2 NFE2L2 siRNA Haematopoietic_and_lymphoid_tissue K562 5.92308 2.56635 0.0027 1 DataSet_02_174
KLF2 LMNA siRNA Haematopoietic_and_lymphoid_tissue K562 0.59788 -0.74206 0.67736 1 DataSet_02_175
KLF2 CEBPZ siRNA Haematopoietic_and_lymphoid_tissue K562 0.30469 -1.7146 0.11843 1 DataSet_02_176
KLF2 VEZF1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.41146 -1.28118 0.65684 1 DataSet_02_179
KLF2 ATF3 siRNA Haematopoietic_and_lymphoid_tissue K562 2 1 0.04741 1 DataSet_02_180
KLF2 STAT5A siRNA Haematopoietic_and_lymphoid_tissue K562 0.37853 -1.40152 0.48246 1 DataSet_02_182
KLF2 BACH1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.30469 -1.7146 0.08149 1 DataSet_02_188
KLF2 RAD21 siRNA Haematopoietic_and_lymphoid_tissue K562 1.96226 0.97252 0.91636 1 DataSet_02_190
KLF2 LMNB2 siRNA Haematopoietic_and_lymphoid_tissue K562 0.39683 -1.33342 0.33288 1 DataSet_02_191
KLF2 MAX siRNA Haematopoietic_and_lymphoid_tissue K562 0.27344 -1.87072 0.06367 1 DataSet_02_192
KLF2 TCP1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.44444 -1.16993 0.40764 1 DataSet_02_194
KLF2 LMNB1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.45312 -1.14202 0.20633 1 DataSet_02_195
KLF2 CDAN1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.54688 -0.87072 0.35794 1 DataSet_02_197
KLF2 UBTF siRNA Haematopoietic_and_lymphoid_tissue K562 1.72222 0.78427 0.22084 1 DataSet_02_198
KLF2 MAZ siRNA Haematopoietic_and_lymphoid_tissue K562 0.61069 -0.71149 0.62075 1 DataSet_02_199
KLF2 E2F4 siRNA Haematopoietic_and_lymphoid_tissue K562 0.37037 -1.43296 0.29557 1 DataSet_02_200
KLF2 TAL1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.28205 -1.82597 0.08971 1 DataSet_02_201
KLF2 ATF3 knockout Colon HCT116 1.81048 0.856374 9.50071104933118e-06 0.00804540695178013 DataSet_03_017
KLF2 ATF4 siRNA Skin A375 0.641433 -0.640631 0.354683764533159 0.775512819201899 DataSet_03_018
KLF2 BCL6 siRNA Lymph OCI-Ly7 DLBCL 1.80351 0.850808 0.0103791920077332 0.55682249714075 DataSet_03_025
KLF2 BCL6 siRNA Lymph Pfeiffer DLBCL 1.89534 0.922455 0.0158972533877948 0.380656796921522 DataSet_03_026
KLF2 CEBPB siRNA Embryo hESC 2.33602 1.22405 0.0397092860037562 0.338730197671742 DataSet_03_049
KLF2 FOXO1 siRNA Skin primary human dermal lymphatic endothelial cells 0.44663 -1.16285 - - DataSet_03_096
KLF2 GATA4 siRNA Stomach KatoIII 0.643555 -0.635866 0.188139671251458 0.908256648479921 DataSet_03_106
KLF2 GATA6 siRNA Stomach YCC3 1.50269 0.587552 0.0839058550706479 0.70677737551678 DataSet_03_110
KLF2 IRF4 siRNA Skin Cutaneous T cell lymphoma HuT-102 cells 1.63593 0.710115 0.361801965621559 0.999948959532916 DataSet_03_134
KLF2 KDM3A siRNA Mammary_gland MCF7 1.89806 0.924526 6.05174227110485e-05 0.00310131678513607 DataSet_03_146
KLF2 Klf4 siRNA Skin Primary neonatal keratinocytes 0.650163 -0.621127 0.00289535911747662 0.0186487024485821 DataSet_03_147
KLF2 KLF5 siRNA Colon SW480 0.626463 -0.6747 0.0756977827450906 0.421239522750893 DataSet_03_148
KLF2 KLF5 siRNA Stomach AGS 2.00444 1.0032 0.0532405496402346 0.498454000198564 DataSet_03_149
KLF2 MITF siRNA Skin SK-MEL-5 0.483325 -1.04894 8.47626605501592e-06 8.17697743088491e-05 DataSet_03_168
KLF2 MYB siRNA Cord_Blood CD34+ progenitor cells 2.50522 1.32494 - - DataSet_03_170
KLF2 MYC siRNA Central_nervous_system DAOY M2.1 1.56721 0.6482 9.57275281358576e-06 4.80412426832444e-05 DataSet_03_178
KLF2 MYCN siRNA Brain BE(2)C cells 2.28358 1.1913 - - DataSet_03_187
KLF2 MYCN siRNA Brain BE(2)C cells 1.98811 0.9914 - - DataSet_03_188
KLF2 NFAT5 siRNA Synovial Primary fibroblast-like synoviocytes 0.367708 -1.44337 0.0930466629221689 0.448215954769219 DataSet_03_194
KLF2 NFAT5 siRNA Umbilical_vein HUVEC 2.83151 1.50157 2.21683061025307e-07 0.000114801458068503 DataSet_03_195
KLF2 NR4A3 siRNA Pancreas 1.1B4 0.475638 -1.07206 1.5990299395953e-06 4.1549321421282e-05 DataSet_03_203
KLF2 OSR1 siRNA Skin Fibroblast 0.573139 -0.803042 4.9746860388904e-05 0.0042607447108338 DataSet_03_204
KLF2 RELB siRNA Immortalized_keratinocyte HaCaT 0.218384 -2.19506 2.14272481793231e-07 8.00675638769912e-06 DataSet_03_227
KLF2 SATB1 siRNA Peripheral_blood CD4+ T cells 1.53051 0.614014 0.147528638303014 0.999960966858709 DataSet_03_231
KLF2 SOX11 siRNA Lung_fibroblast NHLF 0.647439 -0.627185 0.101110650373281 0.440127892962421 DataSet_03_238
KLF2 SP1 siRNA Mammary_gland MDA-MB-231 4.15314 2.0542 0.154605299496694 0.413972819854456 DataSet_03_250
KLF2 SP1 siRNA Ovary OVSAYO 1.58354 0.663158 0.0399704293282998 0.245223985338488 DataSet_03_251
KLF2 SSRP1 siRNA Brain BE(2)C cells 3.0746 1.6204 4.49729643251141e-06 0.0272409736631745 DataSet_03_255
KLF2 STAT6 siRNA Umbilical_vein HUVEC 0.664662 -0.589307 0.207744864759665 0.850858705085608 DataSet_03_264
KLF2 TBX3 siRNA Skin Fibroblast 0.565063 -0.823518 1.26371102407359e-05 0.00111264450012708 DataSet_03_265
KLF2 TFAP2C siRNA Mammary_gland MCF7 0.629252 -0.66829 0.0415388771138613 0.365375126526587 DataSet_03_274
KLF2 TWIST2 siRNA Skin Fibroblast 0.579262 -0.787713 4.67989855878501e-05 0.00817847726924641 DataSet_03_284
KLF2 ZNF750 siRNA Skin Primary neonatal keratinocytes 0.629998 -0.66658 0.00461953186274592 0.0556946272765112 DataSet_03_294
KLF2 APTX CRISPR Haematopoietic_and_lymphoid_tissue K562 0.533333 -0.906891 0.0295481284726953 0.511893657033858 DataSet_04_001
KLF2 CIZ1 CRISPR Haematopoietic_and_lymphoid_tissue K562 1.55172 0.633872 0.410931314484702 0.509526596382555 DataSet_04_004
KLF2 CTCF CRISPR Haematopoietic_and_lymphoid_tissue K562 0.505618 -0.98388 0.00128542301558042 0.297509857470707 DataSet_04_005
KLF2 E4F1 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.58427 -0.775294 0.00246602789312402 0.428981280702047 DataSet_04_007
KLF2 EIF2AK2 CRISPR Haematopoietic_and_lymphoid_tissue K562 2.58823 1.37197 0.000536703296224569 0.31877284568794 DataSet_04_008
KLF2 MECP2 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.485714 -1.04182 0.332626524586826 0.862629650648121 DataSet_04_013
KLF2 NKRF shRNA Haematopoietic_and_lymphoid_tissue K562 37.9567 5.24628 0.311477772086657 0.460773267072953 DataSet_04_014
KLF2 RPS3 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.653846 -0.612977 0.627760236158967 0.865887144934797 DataSet_04_017
KLF2 ANXA2 CRISPR Liver HepG2 0.485714 -1.04182 0.31525723349654 0.77975142857408 DataSet_04_024
KLF2 WRN shRNA Liver HepG2 1.6 0.678072 0.297222153482901 0.527476476760972 DataSet_04_038
KLF2 DDX20 CRISPR Liver HepG2 0.6 -0.736966 0.616727339966154 0.735891072745749 DataSet_04_043
KLF2 APTX CRISPR Liver HepG2 1.6 0.678072 0.798064744963422 0.99600891928032 DataSet_04_069
KLF2 CNOT7 CRISPR Liver HepG2 0.6 -0.736966 0.659171784980355 0.792108424053782 DataSet_04_045
KLF2 DNMT3B CRISPR Liver HepG2 0.25 -2 0.704337115912169 0.880970309146705 DataSet_04_044
KLF2 SEPT11 CRISPR Liver HepG2 0.4375 -1.19265 0.443652089839751 0.692085754152436 DataSet_04_068
KLF2 CCAR1 shRNA Liver HepG2 5.6 2.48543 0.142407351689467 0.266585640007416 DataSet_04_054
KLF2 CNOT7 shRNA Liver HepG2 1.66667 0.736966 0.896955179260373 0.935453704931998 DataSet_04_051
KLF2 NPM1 shRNA Liver HepG2 0.136364 -2.87447 0.460668625339149 0.830315609408191 DataSet_04_058
KLF2 UBE2L3 shRNA Liver HepG2 23 4.52356 0.115701372627619 0.222867535756704 DataSet_04_055
KLF2 YBX3 shRNA Liver HepG2 11 3.45943 0.191567327665058 0.371945289956295 DataSet_02_98
KLF2 DDX17 CRISPR Haematopoietic_and_lymphoid_tissue K562 1.53846 0.621488 0.580671100375944 0.916946165932916 DataSet_04_047
KLF2 SEPT11 CRISPR Haematopoietic_and_lymphoid_tissue K562 1.6875 0.754888 0.662682319834616 1 DataSet_04_077
KLF2 SMG5 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.625 -0.678072 0.631229760673502 0.894698733729509 DataSet_04_073
KLF2 SMG7 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.125 -3 0.277705527693574 0.63244882138706 DataSet_04_075
KLF2 DPF2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.397463 -1.33111 0.00470755759341644 0.023287054518205 DataSet_02_14
KLF2 ERF CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.378436 -1.40188 0.00260393888840908 0.0222552969681587 DataSet_02_34
KLF2 HMGN3 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.58351 -0.777172 0.203333280161806 0.686484485543732 DataSet_02_45
KLF2 LDB1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.5074 -0.978806 0.00824621983280464 0.0362327169916605 DataSet_02_35
KLF2 NFE2L1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.587738 -0.766755 0.150761084338133 0.452629788663993 DataSet_02_32
KLF2 SMARCA4 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.372093 -1.42626 0.00403466230520029 0.02225287025361 DataSet_02_47
KLF2 TBL1XR1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.520085 -0.943182 0.0153489118282818 0.0662380734447258 DataSet_02_43
KLF2 TEAD2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.38055 -1.39384 0.00280338569201755 0.0155377845543553 DataSet_02_33
KLF2 TLE2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.560254 -0.835848 0.0204134125280761 0.0799158234351455 DataSet_02_53
KLF2 CNOT7 shRNA Haematopoietic_and_lymphoid_tissue K562 2.25 1.16992 0.329746090164416 0.532272356039643 DataSet_04_061
KLF2 DDX1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.395833 -1.33703 0.509270520934992 0.84360708472273 DataSet_04_063
KLF2 HDGF shRNA Haematopoietic_and_lymphoid_tissue K562 3.16667 1.66297 0.549951950414962 0.677673990873329 DataSet_04_059
KLF2 PRPF6 shRNA Haematopoietic_and_lymphoid_tissue K562 0.0555556 -4.16993 0.153002052577899 0.517223023612826 DataSet_04_065
KLF2 CNOT3 shRNA Lung A549 2.10712 1.07527 9.584327e-02 0.8830540 DataSet_03_340
KLF2 TET1 siRNA Lung H1299 1.68109 0.7494 - - DataSet_03_319
KLF2 TET1 siRNA Lung H1299 1.68109 0.7494 - - DataSet_03_321
KLF2 NFKBIZ knockout Colon Colon organoid 0.65135 -0.618496 2.689796e-02 0.620790401 DataSet_03_323
KLF2 SMARCA4 siRNA Colon HCT116 1.84511 0.883708 7.921318e-02 9.029053e-01 DataSet_03_301
KLF2 SMARCA4 siRNA Colon HCT116 2.15227 1.10586 2.611723e-03 0.1301247 DataSet_03_302
KLF2 NSD2 shRNA Haematopoietic_and_lymphoid_tissue K562 1.53753 0.620617 1.542100e-06 2.127155e-04 DataSet_03_303
KLF2 SNAI2 shRNA Pancreas pancreatic cancer stem cells 2.24278 1.16529 3.311442e-03 0.5311185 DataSet_03_306
KLF2 SNAI2 shRNA Pancreas KLM1 2.43607 1.28455 4.000541e-02 0.27468516 DataSet_03_307
KLF2 PRMT1 shRNA Lung A549 0.362202 -1.46513 - - DataSet_03_342
KLF2 INO80 siRNA Muscle RD 2.62436 1.39196 - - DataSet_03_344
KLF2 EZH2 shRNA Mammary_gland MCF7 2.32027 1.2143 7.105503e-07 1.332856e-04 DataSet_03_331
KLF2 EZH2 knockdown Colon HCT116 2.00302 1.00218 0.145804102 0.8488990 DataSet_03_334
KLF2 BCL3 siRNA Central_nervous_system U87 0.613987 -0.70372 2.116238e-06 1.572170e-04 DataSet_03_336
KLF2 SKI CRISPR Blood HL60 3.82397 1.93507 1.516859e-02 0.229362785 DataSet_03_351
KLF2 ETV5 knockdown Colon HT29 4.05 2.01792 6.536468e-03 0.094585909 DataSet_03_353
KLF2 TET1 CRISPR Mammary_gland Hs578T 1.95908 0.97018 3.430428e-03 2.421682e-02 DataSet_03_355
KLF2 CREBBP CRISPR Brain U5-NPC 2.85688 1.51444 0.3013615512 0.7490853 DataSet_03_356
KLF2 PTPN14 CRISPR Brain U5-NPC 0.499754 -1.00071 9.030905e-02 0.31616418 DataSet_03_357
KLF2 TP53 CRISPR Brain U5-NPC 7.30092 2.86808 3.444310e-03 1.623145e-01 DataSet_03_358
KLF2 RUNX1 shRNA Haematopoietic_and_lymphoid_tissue OCI-AML5 0.0610494 -4.03388 6.418773e-02 2.660463e-01 DataSet_03_359
KLF2 NCOA2 siRNA Uterus endometrial stromal cells 0.623644 -0.681205 0.5217480744 1 DataSet_03_360
KLF2 ARID2 shRNA Haematopoietic_and_lymphoid_tissue MM.1S 0.493111 -1.02002 5.762930e-04 2.224675e-03 DataSet_03_362
KLF2 DNMT3A knockout Embryo_kidney HEK293T 1.52078 0.604816 - - DataSet_03_369
KLF2 ZFP36L1 siRNA Urinary_bladder J82 3.19547 1.67603 - - DataSet_03_371
KLF2 BHLHE40 shRNA Cervix HeLaS3 1.84556 0.884059 1.530230e-01 0.84447131 DataSet_03_372
KLF2 E2F1 siRNA Nasopharynx HK1 1.92894 0.947809 2.538786e-01 9.431105e-01 DataSet_03_373
KLF2 HNRNPU siRNA Colon RKO 0.65216 -0.616703 - - DataSet_03_374
KLF2 GLI1 siRNA Skeletal_muscle RMS13 0.59101 -0.758745 3.087213e-02 0.145503396 DataSet_03_375
KLF2 DDX5 shRNA Stomach HGC-27 4.0767 2.0274 - - DataSet_03_379
KLF2 DNMT1 siRNA Skin Human melanoma cells 2.67953 1.42198 6.954687e-04 2.356120e-03 DataSet_03_382
KLF2 TCF19 CRISPR Oral_squamous CAL27 2.83082 1.50122 2.113985e-04 0.0089547040 DataSet_03_383
KLF2 YY1 shRNA Brain GSC1517 1.80702 0.853611 - - DataSet_03_384
KLF2 KAT6A CRISPR Haematopoietic_and_lymphoid_tissue MOLM-13 1.67907 0.747658 0.1352682422 0.8388073 DataSet_03_387
KLF2 NFKBIA shRNA Bone_marrow U2OS 0.403332 -1.30996 4.534956e-01 0.87005461 DataSet_03_389
KLF2 KDM5A CRISPR Lung GLC16 0.530969 -0.913302 5.895892e-01 0.734392310 DataSet_03_392
KLF2 ILF2 siRNA Stomach SGC-7901 2.84884 1.51037 0.3698263153 0.57370757 DataSet_03_393
KLF2 BMI1 shRNA Bile_duct QBC-939 0.614797 -0.701819 3.603306e-02 0.1056678854 DataSet_03_395
KLF2 RELA CRISPR Brain T30 0.112307 -3.15448 0.2780566362 0.8400824 DataSet_03_399
KLF2 HMGA1 shRNA Bile_duct HUCCT1 1.82198 0.865506 2.036962e-03 0.053503223 DataSet_03_400
KLF2 EHF shRNA Stomach MKN7 50.8184 5.66728 - - DataSet_03_402
KLF2 JARID2 siRNA Adipose_tissue human adipose tissue derived stem cells 1.93657 0.953502 4.246313e-01 0.5747889 DataSet_03_403
KLF2 CDK7 shRNA Bone_marrow D458 66.5 6.05528 2.935060e-04 0.05173632 DataSet_03_404
KLF2 MAP3K7 shRNA Prostate LNCaP 0.634146 -0.657112 5.699370e-01 7.547685e-01 DataSet_03_408
KLF2 STRAP knockout Nerve SK-N-AS 3.73861 1.9025 - - DataSet_03_409
KLF2 SIRT1 siRNA Pancreas PANC1 0.478873 -1.06228 2.869062e-02 0.094872242 DataSet_03_410
KLF2 USP22 shRNA Liver HuH7 0.657133 -0.605744 - - DataSet_03_411
KLF2 E2F2 siRNA Prostate LNCaP 0.465278 -1.10384 2.307190e-02 1.144152e-01 DataSet_03_414
KLF2 ZKSCAN3 CRISPR Colon HCT116 0.441379 -1.17991 2.070872e-02 0.309071987 DataSet_03_415
KLF2 RUNX2 shRNA Cord_blood Natural Killer Cell 1.50506 0.589825 5.424094e-02 0.793390621 DataSet_03_416
KLF2 NFATC2 shRNA Haematopoietic_and_lymphoid_tissue THP-1 1.50552 0.590267 5.589798e-01 0.692135848 DataSet_03_418
KLF2 FOXK2 shRNA Ovary OVCAR-5 4.60662 2.20371 1.220833e-03 0.08266460 DataSet_03_419
KLF2 BRD4 CRISPR Lymph CD8+ T cells 0.636125 -0.652619 - - DataSet_03_420
KLF2 PRDM1 CRISPR Lymph CD8+ T cells 0.550882 -0.860184 - - DataSet_03_421
KLF2 MAEL CRISPR Liver Alexander cells 0.390476 -1.35669 - - DataSet_03_423
KLF2 IKZF2 shRNA Lymph Hut78 0.568236 -0.815439 1.892439e-01 0.69225766 DataSet_03_429
KLF2 USP7 shRNA Skin xenograft cells 0.444528 -1.16965 0.26093206 0.4348960 DataSet_03_431
KLF2 PLAG1 shRNA Cord_blood Lin-CD34+ HSPCs 0.545455 -0.874469 - - DataSet_03_432
KLF2 POU2AF1 CRISPR Haematopoietic_and_lymphoid_tissue OCI-Ly7 3.7454 1.90512 3.410473e-02 0.441119773 DataSet_03_434
KLF2 POU2AF1 CRISPR Lymph SUDHL4 16.6691 4.0591 7.375445e-04 0.011054539 DataSet_03_435
KLF2 EP300 knockout Pancreas HPAF-II orthotopic cells 1.57354 0.654017 7.697674e-03 3.472432e-02 DataSet_03_436
KLF2 FOXA2 CRISPR Liver iPSCs-derived progenitors and mature hepatocytes 3.9375 1.97728 7.777564e-02 0.90558273 DataSet_03_439
KLF2 SETDB1 shRNA Colon HCT116 2.49602 1.31963 - - DataSet_03_440
KLF2 PURA siRNA Cervix HeLa 1.875 0.906891 1.931513e-01 0.435352978 DataSet_03_444
KLF2 RELB CRISPR Colon SW480 1.51264 0.597064 2.423146e-02 1.258944e-01 DataSet_03_449
KLF2 OGT siRNA Embryo BeWo cells 1.51136 0.595851 8.659982e-03 0.35842467 DataSet_03_453
KLF2 SMARCA2 shRNA Lung HCC2302 0.386618 -1.37102 2.986764e-09 1.541264e-08 DataSet_03_455
KLF2 PPARG siRNA Aortic_valve Valvular endothelial cell 1.74094 0.799863 3.173896e-04 1.531163e-02 DataSet_03_456
KLF2 SREBF2 siRNA Umbilical_vein HUVEC 4.55795 2.18839 7.007772e-05 1.045276e-02 DataSet_03_457
KLF2 ARID1A shRNA Bile_duct MMNK1 3.75342 1.90821 1.050625e-04 0.011240404 DataSet_03_458
KLF2 IRF2 shRNA Cord_Blood CD34+ cells 0.620438 -0.688641 - - DataSet_03_460
KLF2 TXNIP shRNA Cord_Blood CD34+ cells 0.608696 -0.716207 - - DataSet_03_461
KLF2 TXNIP shRNA Cord_blood ST3 0.235616 -2.08549 1.147076e-02 0.1621907732 DataSet_03_462
KLF2 PARP1 knockout Embryo_kidney HEK293a 2.53038 1.33935 7.704232e-05 5.327612e-04 DataSet_03_464
KLF2 STAT3 shRNA Liver HepG2 2.16547 1.11468 1.175018e-02 0.1630082946 DataSet_03_465
KLF2 SMARCA1 Cas13 Embryo_kidney HEK293T 0.197531 -2.33985 - - DataSet_03_466
KLF2 SMARCA1 CRISPR-Csm Embryo_kidney HEK293T 1.80247 0.849975 - - DataSet_03_467
KLF2 SMARCA1 shRNA Embryo_kidney HEK293T 0.641975 -0.63941 - - DataSet_03_468
KLF2 LIN28A siRNA Mammary_gland MCF7M 1.55282 0.634887 2.224828e-01 0.5997426 DataSet_03_469
KLF2 LIN28A siRNA Mammary_gland MCF7M 1.55282 0.634887 2.224828e-01 0.5997426 DataSet_03_470
KLF2 WHSC1 siRNA Prostate PC3 0.632143 -0.661677 2.754933e-02 0.16043901 DataSet_03_471
KLF2 CHCHD3 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.153846 -2.70044 0.3920435 0.9243131 DataSet_04_071
KLF2 APTX CRISPR Haematopoietic_and_lymphoid_tissue K562 0.533333 -0.906891 0.4622695 0.8369086 DataSet_04_072
KLF2 CDC5L CRISPR Haematopoietic_and_lymphoid_tissue K562 0.461538 -1.11548 0.5728568 0.721593818 DataSet_04_074
Regulation Region
 
T(co)Fs that significantly regulate CDK7 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of KLF2
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines