Gene Overview
Target Gene: PROS1
NCBI Official Symbol: PROS1
Entrez ID: 5627
Ensembl ID: ENSG00000184500
Gene Full Name: protein S
Strand: -
Gene Locus: 3q11.1
External Links:

PROS1 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate PROS1   
T(co)Fs that Repress PROS1
The Intensity of the Gene Regulated by T(co)Fs:
PROS1-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
PROS1 MYB shRNA Fetal_liver Primary CD34+ hematopoietic stem/progenitor cells (HSPCs) 0.59051 -0.75996 1.26154e-06 1.57654e-05 DataSet_01_102
PROS1 FOXA1 shRNA Prostate 22RV1 0.48222 -1.05225 - - DataSet_01_105
PROS1 FOXO1 shRNA Bone EWS-FLI1 0.56011 -0.83622 0.03556 0.36174 DataSet_01_106
PROS1 SPDEF shRNA Mammary_gland MCF7 0.40993 -1.28655 0.62759 0.99999 DataSet_01_107
PROS1 HOXA1 siRNA Lung_fibroblast IMR-90 2.30223 1.20303 0.18562 0.46264 DataSet_01_110
PROS1 GABPA siRNA Lung A549 2.11629 1.08154 1.78255e-06 1.71586e-05 DataSet_01_113
PROS1 TCF3 shRNA Mammary_gland MDA-MB468 3.07548 1.62081 1.68767e-06 0.00014 DataSet_01_116
PROS1 ID1 siRNA Lung A549 1.85025 0.88772 0.02429 0.18432 DataSet_01_117
PROS1 ZNF91 siRNA Gastrointestinal_tissue GIST-T1 1.64928 0.72184 0.00013 0.00576 DataSet_01_123
PROS1 ZNF100 siRNA Gastrointestinal_tissue GIST-T1 1.68575 0.75339 9.69672e-05 0.00624 DataSet_01_124
PROS1 ZNF431 siRNA Gastrointestinal_tissue GIST-T1 1.5188 0.60293 0.00051 0.00543 DataSet_01_128
PROS1 ID1 shRNA Neuroepithelium GSC2 1.88613 0.91543 9.67234e-11 1.80044e-09 DataSet_01_133
PROS1 ID1 shRNA Neuroepithelium GSC8 0.38549 -1.37525 1.66026e-12 3.32052e-11 DataSet_01_134
PROS1 SPDEF shRNA Mammary_gland MCF7 0.62183 -0.68541 0.00082 0.04165 DataSet_01_135
PROS1 IKZF2 shRNA Haematopoietic_and_lymphoid_tissue JURKAT 2.50815 1.32662 0.01572 0.38044 DataSet_01_137
PROS1 IKZF1 shRNA Haematopoietic_and_lymphoid_tissue JURKAT 3.28269 1.71488 0.00385 0.83692 DataSet_01_138
PROS1 POLR3A siRNA Mammary_gland MCF7 1.61064 0.68764 - - DataSet_01_139
PROS1 TFAP2C shRNA Mammary_gland MCF7 4.35378 2.12227 5.05345e-07 3.2452e-06 DataSet_01_150
PROS1 MYCN siRNA Autonomic_ganglia SKNBE2 1.77913 0.83117 0.01846 0.17544 DataSet_01_160
PROS1 ETV1 shRNA Prostate LNCaP 1.85639 0.8925 0.01137 0.04164 DataSet_01_161
PROS1 HSF1 shRNA Liver KYN2 1.85932 0.89477 - - DataSet_01_178
PROS1 TP63 siRNA Immortalized_keratinocyte HaCaT RG 0.1215 -3.04103 - - DataSet_01_196
PROS1 ATF2 siRNA Haematopoietic_and_lymphoid_tissue K562 1.91634 0.93835 0.15646 0.98802 DataSet_01_206
PROS1 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly10 0.58805 -0.76598 - - DataSet_01_208
PROS1 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly1 3.1909 1.67396 - - DataSet_01_209
PROS1 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly7 0.15365 -2.70227 - - DataSet_01_210
PROS1 REST siRNA Prostate LNCaP 0.63442 -0.65649 0.07816 0.32128 DataSet_01_211
PROS1 EGR3 shRNA Prostate M12 0.35725 -1.48501 0.00026 0.01974 DataSet_01_212
PROS1 PTEN shRNA Mammary_gland MCF10A 2.93138 1.55158 5.66412e-10 1.34343e-07 DataSet_01_218
PROS1 KLF2 shRNA Bone_marrow RPMI8226 0.34632 -1.52982 0.00657 0.43119 DataSet_01_226
PROS1 MYC shRNA Soft_tissue HT1080 1.69737 0.7633 - - DataSet_01_237
PROS1 STAT5 shRNA Haematopoietic_and_lymphoid_tissue K562 1.75945 0.81512 5.88738e-05 0.00119 DataSet_01_239
PROS1 TWIST1 shRNA Stomach CAF14 1.54663 0.62913 0.10317 0.99996 DataSet_01_252
PROS1 YBX1 shRNA Mammary_gland MDA 1.56131 0.64276 0.00012 0.01617 DataSet_01_258
PROS1 SIX4 siRNA Ovary PEO1 2.25595 1.17373 0.00038 0.00773 DataSet_01_269
PROS1 AR shRNA Prostate CWR22Pc 1.88821 0.91702 0.00435 0.03684 DataSet_01_278
PROS1 NFYA shRNA Colon HCT1163 0.59477 -0.74959 1.96782e-05 0.00266 DataSet_01_287
PROS1 POSTN shRNA Brain GSC272 0.30471 -1.71448 0.0301 0.51982 DataSet_01_293
PROS1 TFAP4 siRNA Brain BE(2)-C 0.21092 -2.24524 0.43577 0.51625 DataSet_01_295
PROS1 MYCN siRNA Brain BE(2)-C 1.54927 0.63159 0.81799 1 DataSet_01_296
PROS1 PTEN shRNA Skin A431 0.19782 -2.33773 0.00532 0.0803 DataSet_01_301
PROS1 HOXA5 shRNA Mammary_gland MCF10A 1.80126 0.84901 7.64521e-05 0.11544 DataSet_01_305
PROS1 NR2E1 shRNA Neuroepithelium PBT003 0.35853 -1.47982 0.00043 0.35359 DataSet_01_306
PROS1 ARNT siRNA Upper_aerodigestive_tract HSC3 4.16793 2.05933 - - DataSet_01_315
PROS1 ZNF25 siRNA Bone_marrow hMSC-TERT4 1.904 0.92903 0.78564 0.96572 DataSet_01_319
PROS1 MYC siRNA Colon HCT116 2.53657 1.34288 5.973e-07 5.51412e-06 DataSet_01_324
PROS1 TP63 shRNA Head_and_neck FaDU 1.54385 0.62654 4.08532e-05 0.00121 DataSet_01_327
PROS1 TP63 shRNA Head_and_neck FaDU 1.54385 0.62654 4.08532e-05 0.00121 DataSet_01_330
PROS1 KLF4 siRNA Embryo HCE 1.62675 0.70199 0.00089 0.10984 DataSet_01_339
PROS1 ETV4 shRNA Prostate PC3 1.58 0.65993 - - DataSet_01_356
PROS1 GTF2B siRNA Cervix HeLa 2.06697 1.04751 - - DataSet_01_362
PROS1 SAFB2 shRNA Liver HepG2 0.38554 -1.37504 0.00018 0.02192 DataSet_02_102
PROS1 U2AF2 shRNA Liver HepG2 1.78042 0.83222 0.85435 0.90891 DataSet_02_105
PROS1 TAF15 shRNA Liver HepG2 2.00672 1.00484 0.00034 0.01075 DataSet_02_106
PROS1 BCLAF1 shRNA Liver HepG2 0.48986 -1.02955 0.00154 0.02576 DataSet_02_112
PROS1 TARDBP shRNA Liver HepG2 1.76159 0.81688 0.00441 0.02549 DataSet_02_116
PROS1 RBM25 shRNA Liver HepG2 1.65831 0.72971 0.00202 0.02312 DataSet_02_119
PROS1 PCBP2 shRNA Liver HepG2 1.7217 0.78383 0.00374 0.05808 DataSet_02_123
PROS1 SRSF3 shRNA Liver HepG2 1.64323 0.71653 0.00441 0.07178 DataSet_02_127
PROS1 TAF15 shRNA Haematopoietic_and_lymphoid_tissue K562 1.57975 0.6597 0.07156 0.30612 DataSet_02_163
PROS1 RAD21 siRNA Haematopoietic_and_lymphoid_tissue K562 2.97134 1.57111 0.80259 1 DataSet_02_190
PROS1 AR siRNA Prostate abl cells 1.96865 0.977209 0.0316436401456462 0.999852161656754 DataSet_03_004
PROS1 AR siRNA Mammary_gland MCF7 1.5168 0.601033 1.42103228247959e-05 0.000949449007823732 DataSet_03_006
PROS1 ARID2 CRISPR Liver JHH4 1.91676 0.938672 0.52298943822308 1 DataSet_03_015
PROS1 ATF3 knockout Colon HCT116 1.52857 0.61218 0.000693875590388315 0.127000733335251 DataSet_03_017
PROS1 BCL6 siRNA Lymph Pfeiffer DLBCL 1.64523 0.718289 0.0305735022638846 0.448070390409636 DataSet_03_026
PROS1 CEBPB siRNA Embryo hESC 1.78453 0.835544 0.257163818541697 0.638781827263804 DataSet_03_049
PROS1 CREBBP siRNA Mammary_gland MCF7 1.70544 0.770141 0.0108068553402555 0.963067261754673 DataSet_03_055
PROS1 GATA3 siRNA Mammary_gland MCF7 0.588753 -0.764265 0.000461605396967766 0.0234915820241854 DataSet_03_103
PROS1 GATA4 siRNA Stomach AGS 0.386505 -1.37144 0.095340385523047 0.743365661227971 DataSet_03_105
PROS1 GATA4 siRNA Stomach KatoIII 3.46994 1.79491 0.000959727940260042 0.585654148577719 DataSet_03_106
PROS1 GATA6 siRNA Stomach KatoIII 3.69168 1.88428 1.88957337542168e-05 0.0340989262039637 DataSet_03_109
PROS1 JARID1A siRNA Autonomic_ganglia SKNBE2 1.54537 0.627953 0.011678890059863 0.269276320935111 DataSet_03_135
PROS1 JUN siRNA Fibroblasts WI38 2.04253 1.03036 0.0125844406485691 0.0703041280834321 DataSet_03_140
PROS1 JUN siRNA Fibroblasts WI38 2.04253 1.03036 0.0125777375253228 0.0701894205467366 DataSet_03_141
PROS1 KDM3A siRNA Mammary_gland MCF7 1.67644 0.745402 0.000130724084990908 0.00493851899783966 DataSet_03_146
PROS1 Klf4 siRNA Skin Primary neonatal keratinocytes 2.63352 1.39699 5.38865628476265e-05 0.00152338579434119 DataSet_03_147
PROS1 KLF5 siRNA Stomach KatoIII 2.33753 1.22499 0.0631499541820937 0.471881386408985 DataSet_03_150
PROS1 MITF siRNA Skin Ma-Mel-15 1.79839 0.846704 0.0292092773280871 0.338964250288002 DataSet_03_166
PROS1 MITF siRNA Skin SK-MEL-5 0.538068 -0.894141 0.000116551623063645 0.000626267651806147 DataSet_03_168
PROS1 MYB siRNA Cord_Blood CD34+ progenitor cells 1.88193 0.91221 - - DataSet_03_170
PROS1 MYC siRNA Colon HT29 3.63246 1.86095 - - DataSet_03_177
PROS1 MYC siRNA Central_nervous_system DAOY M2.1 1.66773 0.737887 1.98443175845117e-07 2.53301109884742e-06 DataSet_03_178
PROS1 MYCN siRNA Autonomic_ganglia SKNBE2 1.77913 0.831172 0.0177646960958479 0.179133118690993 DataSet_03_185
PROS1 NR4A3 siRNA Pancreas 1.1B4 1.91993 0.941057 1.53366459829158e-05 0.000201370524324148 DataSet_03_203
PROS1 PBX1 siRNA Mammary_gland MCF7 2.05168 1.03681 1.58157866276282e-06 0.00097908421396982 DataSet_03_209
PROS1 PHB shRNA Embryo Embryonic stem cells (ESCs) 2.75977 1.46455 0.0150164561495584 0.0435374692621082 DataSet_03_211
PROS1 RELA siRNA Fibroblasts WI38 1.65905 0.730357 0.113806972715142 0.291436152066104 DataSet_03_222
PROS1 RELA siRNA Fibroblasts WI38 1.7325 0.792857 0.038215513850609 0.110415647332555 DataSet_03_223
PROS1 RELB siRNA Immortalized_keratinocyte HaCaT 2.80272 1.48683 4.90400952294387e-05 0.000692323694463092 DataSet_03_227
PROS1 SOX4 siRNA Haematopoietic_and_lymphoid_tissue ST1 0.444444 -1.16992 - - DataSet_03_246
PROS1 SOX9 knockdown Liver HepG2 0.604495 -0.726197 0.000169960973288166 0.00405291896381196 DataSet_03_248
PROS1 SP1 siRNA Cervix HeLa 2.2431 1.16549 1.9761081642522e-05 0.000668634723388772 DataSet_03_249
PROS1 SP1 siRNA Ovary OVSAYO 0.355497 -1.49209 0.000810716556528019 0.0640511599493557 DataSet_03_251
PROS1 SRF siRNA Prostate LNCaP 0.584607 -0.774462 0.00396009900722248 0.0291984828060616 DataSet_03_254
PROS1 STAT3 CRISPR Embryo hESC 0.34043 -1.55457 0.00667063992949832 0.0552016343015924 DataSet_03_258
PROS1 TP53 siRNA Foreskin Neonatal foreskin keratinocytes 1.7706 0.824237 0.0904960600282322 0.999791649573014 DataSet_03_278
PROS1 ZNF746 siRNA Colon HCT116 1.57844 0.6585 - - DataSet_03_293
PROS1 MARK2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.540846 -0.88671 0.00685595041303 0.0239766328554229 DataSet_04_012
PROS1 NKRF shRNA Haematopoietic_and_lymphoid_tissue K562 0.270797 -1.88471 0.0509828844628731 0.138816368469517 DataSet_04_014
PROS1 NUP35 shRNA Haematopoietic_and_lymphoid_tissue K562 0.663567 -0.591686 0.0102306332148837 0.0328505606236846 DataSet_04_015
PROS1 DPF2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 1.51272 0.597145 0.00175774491362466 0.0133282918667888 DataSet_02_14
PROS1 ERF CRISPRi Haematopoietic_and_lymphoid_tissue K562 1.71389 0.777278 0.00115174180086373 0.0160537006972378 DataSet_02_34
PROS1 LDB1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 1.82975 0.871643 0.000523165167104877 0.0131329158828069 DataSet_02_35
PROS1 NFE2L1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 1.50822 0.592846 0.23985528953004 0.513318755881901 DataSet_02_32
PROS1 TEAD2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 2.08337 1.05892 0.000968960042197415 0.00965529714070128 DataSet_02_33
PROS1 HDGF shRNA Haematopoietic_and_lymphoid_tissue K562 0.657732 -0.604429 0.00422376735936578 0.0163412516731947 DataSet_04_059
PROS1 PRPF6 shRNA Haematopoietic_and_lymphoid_tissue K562 1.66396 0.734624 0.00207438940388263 0.212222420431545 DataSet_04_065
PROS1 TET1 siRNA Lung A549 0.629794 -0.667048 - - DataSet_03_318
PROS1 TET1 siRNA Lung H1299 2.59094 1.37347 - - DataSet_03_319
PROS1 TET1 siRNA Lung A549 0.629794 -0.667048 - - DataSet_03_320
PROS1 TET1 siRNA Lung H1299 2.59094 1.37347 - - DataSet_03_321
PROS1 AEBP1 siRNA Umbilical_vein HUVEC 1.54483 0.627451 6.283789e-01 0.999982779 DataSet_03_300
PROS1 EZH2 knockdown Uterus Ishikawa (ISK) cell 2.26926 1.18222 - - DataSet_03_324
PROS1 SMARCA4 siRNA Colon HCT116 1.52733 0.61101 2.802991e-01 9.892536e-01 DataSet_03_301
PROS1 ELF3 CRISPR Bile_duct HBDEC2 0.476823 -1.06847 9.364533e-05 1.167373e-03 DataSet_03_304
PROS1 ELF3 knockdown Bile_duct HBDEC2 1.94719 0.961396 1.835421e-05 3.944049e-03 DataSet_03_305
PROS1 SNAI2 shRNA Pancreas KLM1 0.247669 -2.01351 6.609481e-03 0.14886126 DataSet_03_307
PROS1 PRMT1 shRNA Lung A549 1.6227 0.698399 - - DataSet_03_342
PROS1 INO80 siRNA Muscle RD 0.583357 -0.777548 - - DataSet_03_344
PROS1 AEBP1 siRNA Central_nervous_system U87MG 1.66948 0.739399 1.787987e-02 0.9427693 DataSet_03_338
PROS1 PBX1 siRNA Mammary_gland MCF7 2.05168 1.03681 2.084813e-06 1.147258e-03 DataSet_03_326
PROS1 DNMT1 shRNA Lung hTERT-immortalised adult fibroblasts 2.70389 1.43504 1.220819e-03 8.361730e-02 DataSet_03_311
PROS1 CREBBP CRISPR Brain U5-NPC 1.75898 0.81474 0.2739695304 0.7490853 DataSet_03_356
PROS1 TP53 CRISPR Brain U5-NPC 2.27433 1.18544 1.128635e-01 2.481883e-01 DataSet_03_358
PROS1 ARID2 shRNA Haematopoietic_and_lymphoid_tissue MM.1S 1.5905 0.669485 1.940318e-01 2.903421e-01 DataSet_03_362
PROS1 EP300 shRNA Mammary_gland MCF10AT 55.6667 5.79874 4.474972e-04 0.018435712 DataSet_03_364
PROS1 ZNF148 shRNA Mammary_gland MDA-MB-231 0.384672 -1.3783 1.170322e-03 0.030155976 DataSet_03_366
PROS1 USP22 shRNA Liver PLC_PRF_5 cells 2.12613 1.08823 1.478571e-02 0.13342319 DataSet_03_368
PROS1 ZFP36L1 siRNA Urinary_bladder J82 2.67774 1.42102 - - DataSet_03_371
PROS1 E2F1 siRNA Nasopharynx HK1 0.535544 -0.900923 7.160867e-04 1.656892e-02 DataSet_03_373
PROS1 GLI1 siRNA Skeletal_muscle RMS13 1.72632 0.787699 6.435886e-03 0.058410591 DataSet_03_375
PROS1 ZNF213 siRNA Mammary_gland MCF7 0.189219 -2.40187 1.826629e-02 2.271774e-01 DataSet_03_376
PROS1 DDX5 shRNA Stomach HGC-27 1.76962 0.823443 - - DataSet_03_379
PROS1 DNMT1 siRNA Skin Human melanoma cells 1.73436 0.794401 6.747845e-07 2.381669e-05 DataSet_03_382
PROS1 TCF19 CRISPR Oral_squamous CAL27 0.617562 -0.695344 2.427955e-04 0.0095280234 DataSet_03_383
PROS1 ILF2 siRNA Stomach SGC-7901 3.73077 1.89947 0.2580568117 0.45593562 DataSet_03_393
PROS1 BMI1 shRNA Bile_duct QBC-939 2.02533 1.01816 3.123216e-07 0.0003246453 DataSet_03_395
PROS1 TLE4 CRISPR Lymph CAR T Cell 1.50554 0.590284 1.356305e-01 0.42595684 DataSet_03_398
PROS1 EHF shRNA Stomach MKN7 6.97037 2.80124 - - DataSet_03_402
PROS1 CDK7 shRNA Bone_marrow D458 4.15625 2.05528 3.747816e-03 0.11843688 DataSet_03_404
PROS1 CHD1 shRNA Prostate LNCaP 0.476087 -1.0707 2.186815e-02 3.328284e-01 DataSet_03_407
PROS1 STRAP knockout Nerve SK-N-AS 0.48581 -1.04154 - - DataSet_03_409
PROS1 USP22 shRNA Liver HuH7 2.53735 1.34333 - - DataSet_03_411
PROS1 E2F2 siRNA Prostate LNCaP 1.78299 0.8343 1.620767e-02 9.023575e-02 DataSet_03_414
PROS1 FOXK2 shRNA Ovary OVCAR-5 0.427221 -1.22695 1.440343e-01 0.35545835 DataSet_03_419
PROS1 BRD4 CRISPR Lymph CD8+ T cells 1.50955 0.594123 - - DataSet_03_420
PROS1 PRDM1 CRISPR Lymph CD8+ T cells 1.50318 0.588022 - - DataSet_03_421
PROS1 FOXQ1 CRISPR Lymph Primary CD4+ T cells 0.505319 -0.984733 - - DataSet_03_422
PROS1 STAT3 siRNA Peripheral_blood Monocyte-derived M-CSF macrophages 0.589231 -0.763095 0.0816131480 1 DataSet_03_430
PROS1 USP7 shRNA Skin xenograft cells 0.460956 -1.1173 0.26680014 0.4348960 DataSet_03_431
PROS1 PLAG1 shRNA Cord_blood Lin-CD34+ HSPCs 0.270397 -1.88685 - - DataSet_03_432
PROS1 POU2AF1 CRISPR Haematopoietic_and_lymphoid_tissue OCI-Ly7 2 1 1.811093e-01 0.540033120 DataSet_03_434
PROS1 FOXA2 CRISPR Liver iPSCs-derived progenitors and mature hepatocytes 1.50188 0.586773 2.118095e-01 0.90558273 DataSet_03_439
PROS1 DAXX shRNA Mammary_gland MDA-MB-231 0.578807 -0.788845 2.476340e-03 0.06648051 DataSet_03_441
PROS1 HMG20A siRNA Mammary_gland MDA-MB-231 1.62555 0.700927 0.0054289026 0.1574899 DataSet_03_442
PROS1 PURA siRNA Cervix HeLa 1.58958 0.668643 1.948022e-02 0.125231436 DataSet_03_444
PROS1 RELB CRISPR Colon SW480 2.27509 1.18593 2.891915e-02 1.400858e-01 DataSet_03_449
PROS1 SMARCA2 shRNA Lung HCC2302 3.33683 1.73848 5.793879e-07 1.621372e-06 DataSet_03_455
PROS1 IRF2 shRNA Cord_Blood CD34+ cells 1.74878 0.806346 - - DataSet_03_460
PROS1 TXNIP shRNA Cord_Blood CD34+ cells 1.7482 0.805871 - - DataSet_03_461
PROS1 TXNIP shRNA Cord_blood ST3 3.89286 1.96083 1.779664e-03 0.0739952571 DataSet_03_462
PROS1 STAT3 shRNA Liver HepG2 2.79185 1.48122 5.119311e-04 0.0277003661 DataSet_03_465
PROS1 SMARCA1 CRISPR-Csm Embryo_kidney HEK293T 1.70357 0.768565 - - DataSet_03_467
PROS1 SMARCA1 shRNA Embryo_kidney HEK293T 1.53269 0.61607 - - DataSet_03_468
PROS1 WHSC1 siRNA Prostate PC3 0.371601 -1.42817 2.609792e-04 0.06953019 DataSet_03_471
Regulation Region
 
T(co)Fs that significantly regulate PBX1 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of PROS1
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines