Gene Overview
Target Gene: SPP1
NCBI Official Symbol: SPP1
Entrez ID: 6696
Ensembl ID: ENSG00000118785
Gene Full Name: secreted phosphoprotein 1
Strand: +
Gene Locus: 4q22.1
External Links:

SPP1 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate SPP1   
T(co)Fs that Repress SPP1
The Intensity of the Gene Regulated by T(co)Fs:
SPP1-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
SPP1 SPDEF shRNA Mammary_gland MCF7 0.64701 -0.62814 0.90825 0.99999 DataSet_01_107
SPP1 HOXA1 siRNA Lung_fibroblast IMR-90 1.70372 0.76868 0.00891 0.10096 DataSet_01_110
SPP1 GABPA siRNA Lung A549 0.3447 -1.53658 4.96485e-09 2.19711e-07 DataSet_01_113
SPP1 ID1 siRNA Lung A549 1.91295 0.9358 0.0051 0.11713 DataSet_01_117
SPP1 ZIC2 siRNA Pancreas PANC1 0.17723 -2.49634 - - DataSet_01_121
SPP1 FOXM1 siRNA Central_nervous_system U87 13.0536 3.70637 - - DataSet_01_122
SPP1 ID1 shRNA Neuroepithelium GSC2 3.6215 1.85659 1.43288e-15 9.62416e-13 DataSet_01_133
SPP1 ID1 shRNA Neuroepithelium GSC8 0.3305 -1.59729 2.05302e-13 8.80178e-12 DataSet_01_134
SPP1 IKZF1 shRNA Haematopoietic_and_lymphoid_tissue JURKAT 2.61896 1.38899 0.00877 0.99993 DataSet_01_138
SPP1 GLI2 siRNA Bone_marrow U2OS 0.62702 -0.67341 - - DataSet_01_143
SPP1 ZFX shRNA Haematopoietic_and_lymphoid_tissue NOMO-1 2.94905 1.56025 0.45891 0.99999 DataSet_01_144
SPP1 REST siRNA Adrenal_gland H295R/TR 1.51557 0.59986 5.00665e-05 0.0129 DataSet_01_145
SPP1 MYBL2 shRNA Bone_marrow CD34+ BM cells 0.6047 -0.72571 0.17892 0.49032 DataSet_01_148
SPP1 HSF1 shRNA Skin A375 0.27581 -1.85824 5.88189e-05 0.00155 DataSet_01_155
SPP1 ZFX shRNA Central_nervous_system DAOY 0.58899 -0.76369 0.09246 0.99991 DataSet_01_157
SPP1 ELK1 siRNA Peripheral_blood CD4+ T cells 3.53248 1.82068 0.00046 0.00643 DataSet_01_162
SPP1 GATA3 siRNA Peripheral_blood CD4+ T cells 0.54114 -0.88594 0.12417 0.45167 DataSet_01_163
SPP1 JUN siRNA Peripheral_blood CD4+ T cells 3.93618 1.9768 0.00022 0.0061 DataSet_01_164
SPP1 MAF siRNA Peripheral_blood CD4+ T cells 3.80648 1.92846 0.00024 0.01005 DataSet_01_165
SPP1 NFATC3 siRNA Peripheral_blood CD4+ T cells 4.23586 2.08266 0.00019 0.01091 DataSet_01_166
SPP1 NFKB1 siRNA Peripheral_blood CD4+ T cells 0.64582 -0.63079 0.27947 0.78421 DataSet_01_167
SPP1 HOXB7 siRNA Pancreas MIA PaCa-2 0.54909 -0.8649 0.00537 0.49616 DataSet_01_169
SPP1 STAT3 siRNA Oesophagus OE21 0.51867 -0.94711 0.00805 0.33493 DataSet_01_180
SPP1 GABPA shRNA Prostate C4-2B 1542.4 10.591 0.23771 0.43934 DataSet_01_190
SPP1 GABPA shRNA Prostate LNCaP 1375.81 10.4261 0.4621 0.7048 DataSet_01_191
SPP1 CREB1 shRNA Parotid_gland H3118 MEC 0.30107 -1.73183 0.03245 0.2731 DataSet_01_194
SPP1 TP63 siRNA Immortalized_keratinocyte HaCaT RG 1.52681 0.61052 - - DataSet_01_196
SPP1 TP63 siRNA Head_and_neck SCC-1 1.5109 0.59541 - - DataSet_01_198
SPP1 TP63 siRNA Head_and_neck SCC-012 0.28298 -1.82124 - - DataSet_01_201
SPP1 MITF shRNA Skin COLO829 0.46442 -1.10649 0.00232 0.03673 DataSet_01_207
SPP1 LIN28A siRNA Embryo H9 16.0641 4.00577 3.76211e-07 0.00018 DataSet_01_215
SPP1 TAL1 shRNA Haematopoietic_and_lymphoid_tissue HEL 1.81943 0.86348 0.00048 0.01009 DataSet_01_217
SPP1 SNAI2 shRNA Skin Primary human keratinocytes 1.52096 0.60498 0.18508 0.31794 DataSet_01_225
SPP1 KLF2 shRNA Bone_marrow RPMI8226 1.50727 0.59194 0.68001 0.95058 DataSet_01_226
SPP1 IRX1 shRNA Bone_marrow 143B 0.28656 -1.80311 2.39502e-05 0.00671 DataSet_01_227
SPP1 JUN shRNA Soft_tissue LP6 0.62595 -0.67587 0.39664 0.80765 DataSet_01_230
SPP1 MYC siRNA White_adipose_tissue Adipose stem cells 1.76318 0.81818 7e-04 0.01289 DataSet_01_231
SPP1 FOXA1 siRNA Prostate LNCaP 1.75776 0.81373 0.0149 0.19848 DataSet_01_233
SPP1 MYC shRNA Soft_tissue HT1080 0.66077 -0.59777 - - DataSet_01_237
SPP1 TWIST1 shRNA Stomach CAF14 2.24219 1.16491 0.06321 0.99996 DataSet_01_252
SPP1 TWIST1 shRNA Stomach CAF32 0.24565 -2.02532 0.00019 0.01362 DataSet_01_253
SPP1 MYT1L shRNA Fetal_spinal_cord SPC04 0.6291 -0.66865 0.14846 0.51833 DataSet_01_264
SPP1 MEF2A shRNA Fetal_spinal_cord SPC04 2.21265 1.14578 0.00256 0.87206 DataSet_01_265
SPP1 AHR siRNA Haematopoietic_and_lymphoid_tissue THP-1 1.85909 0.89459 9.54843e-05 0.00174 DataSet_01_283
SPP1 ZIC5 siRNA Skin A375 4.94393 2.30566 - - DataSet_01_284
SPP1 GRHL2 shRNA Ovary OVCA429 1.7277 0.78886 0.38049 0.94426 DataSet_01_289
SPP1 POSTN shRNA Brain GSC272 0.18017 -2.47259 0.00745 0.47578 DataSet_01_293
SPP1 RELB siRNA Lung A549 1.84994 0.88748 0.00366 0.05074 DataSet_01_294
SPP1 TFAP4 siRNA Brain BE(2)-C 0.27447 -1.86529 0.4406 0.51625 DataSet_01_295
SPP1 ARID1B shRNA Liver IRM90 0.4217 -1.24572 1.14151e-06 0.00025 DataSet_01_298
SPP1 SOX17 siRNA Umbilical_vein HUVEC 2.24868 1.16908 0.13491 0.99998 DataSet_01_300
SPP1 PTEN shRNA Skin A431 0.37569 -1.4124 0.00103 0.0655 DataSet_01_301
SPP1 PTEN shRNA Lung HCC827 0.47152 -1.08461 0.00152 0.33787 DataSet_01_302
SPP1 PTEN shRNA Mammary_gland SKBR3 1.50475 0.58953 0.83457 0.94897 DataSet_01_303
SPP1 ETV5 siRNA Soft_tissue hADSC 2.48893 1.31552 2.15217e-06 7e-04 DataSet_01_304
SPP1 NR2E1 shRNA Neuroepithelium PBT003 0.57291 -0.80362 0.17909 0.6026 DataSet_01_306
SPP1 OVOL2 siRNA Corneal_epithelial Corneal epithelial cells 4.35772 2.12357 0.1574 0.38092 DataSet_01_313
SPP1 RUNX1 shRNA Embryo H9 0.59095 -0.7589 0.56581 0.74262 DataSet_01_314
SPP1 FOXO1 shRNA Haematopoietic_and_lymphoid_tissue RS4;11 2.52552 1.33658 4.22281e-05 0.00999 DataSet_01_321
SPP1 FOXO1 shRNA Haematopoietic_and_lymphoid_tissue 018Z 3.54501 1.82579 0.00659 0.90631 DataSet_01_322
SPP1 HOXC6 siRNA Prostate LNCaP 2.05776 1.04108 0.20131 0.99927 DataSet_01_333
SPP1 NFE2L2 siRNA Lung A549 0.30396 -1.71803 9.93583e-09 2.72417e-06 DataSet_01_335
SPP1 TCF7L1 shRNA Colon HCT116 0.57388 -0.80117 0.00014 0.00706 DataSet_01_346
SPP1 HIF1A siRNA Oral_cavity OEC-M1 1.70689 0.77137 0.04552 0.85151 DataSet_01_348
SPP1 SOX2 shRNA Neuroepithelium HF2303 1.98178 0.9868 0.088 1 DataSet_01_349
SPP1 SOX2 siRNA Embryo Undifferentiated hESCs 0.31042 -1.68771 - - DataSet_01_350
SPP1 ELK1 siRNA Mammary_gland MDA-MB-231 0.47525 -1.07323 - - DataSet_01_354
SPP1 PAX3 shRNA Soft_tissue Rh30 2.23276 1.15883 - - DataSet_01_359
SPP1 RBFOX2 shRNA Liver HepG2 0.44789 -1.15879 0.00969 0.65168 DataSet_02_101
SPP1 SAFB2 shRNA Liver HepG2 0.2692 -1.89323 0.00028 0.02192 DataSet_02_102
SPP1 FIP1L1 shRNA Liver HepG2 0.61686 -0.69698 0.02404 0.06819 DataSet_02_103
SPP1 U2AF2 shRNA Liver HepG2 0.56746 -0.81742 0.0155 0.08261 DataSet_02_105
SPP1 TAF15 shRNA Liver HepG2 39.9984 5.32187 2.0541e-05 0.01075 DataSet_02_106
SPP1 SSB shRNA Liver HepG2 0.04281 -4.54582 1.17057e-05 0.00296 DataSet_02_107
SPP1 ZNF622 shRNA Liver HepG2 0.49695 -1.00884 0.01881 0.04356 DataSet_02_108
SPP1 HNRNPUL1 shRNA Liver HepG2 0.18734 -2.41628 0.00021 0.0175 DataSet_02_109
SPP1 GTF2F1 shRNA Liver HepG2 1.77647 0.82901 0.0017 0.20753 DataSet_02_110
SPP1 RBM39 shRNA Liver HepG2 0.56957 -0.81205 0.01381 0.21151 DataSet_02_111
SPP1 U2AF2 shRNA Liver HepG2 0.57804 -0.79077 0.00506 0.05952 DataSet_02_113
SPP1 PCBP1 shRNA Liver HepG2 5.2427 2.39031 0.00017 0.01339 DataSet_02_115
SPP1 TARDBP shRNA Liver HepG2 0.05991 -4.06095 4.46199e-05 0.0163 DataSet_02_116
SPP1 SUB1 shRNA Liver HepG2 2.43303 1.28276 0.00073 0.12645 DataSet_02_117
SPP1 CEBPZ shRNA Liver HepG2 0.61272 -0.70671 0.90207 1 DataSet_02_118
SPP1 RBM25 shRNA Liver HepG2 3.72738 1.89816 0.00034 0.02139 DataSet_02_119
SPP1 PTBP1 shRNA Liver HepG2 2.55438 1.35297 0.00294 0.01101 DataSet_02_120
SPP1 PCBP2 shRNA Liver HepG2 2.31748 1.21256 0.00083 0.04878 DataSet_02_123
SPP1 FUS shRNA Liver HepG2 1.96274 0.97287 9e-04 0.05046 DataSet_02_124
SPP1 HNRNPLL shRNA Liver HepG2 0.02519 -5.31095 6.02224e-05 0.01076 DataSet_02_125
SPP1 SNRNP70 shRNA Liver HepG2 0.22626 -2.14398 0.00062 0.03074 DataSet_02_126
SPP1 FIP1L1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.6 -0.73697 0.11455 0.24103 DataSet_02_147
SPP1 SAFB2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.4026 -1.31259 0.59582 0.87143 DataSet_02_150
SPP1 ILF2 shRNA Haematopoietic_and_lymphoid_tissue K562 2 1 0.10434 0.38683 DataSet_02_152
SPP1 LMNA siRNA Haematopoietic_and_lymphoid_tissue K562 3.44737 1.7855 0.95764 1 DataSet_02_175
SPP1 VEZF1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.22857 -2.12928 0.0608 1 DataSet_02_179
SPP1 STAT5A siRNA Haematopoietic_and_lymphoid_tissue K562 0.3 -1.73697 0.92496 1 DataSet_02_182
SPP1 MAFK siRNA Haematopoietic_and_lymphoid_tissue K562 8.33333 3.05889 0.1519 1 DataSet_02_183
SPP1 CHD1 siRNA Haematopoietic_and_lymphoid_tissue K562 6.5 2.70044 0.03096 1 DataSet_02_187
SPP1 BACH1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.14286 -2.80735 0.55044 1 DataSet_02_188
SPP1 MAFG siRNA Haematopoietic_and_lymphoid_tissue K562 5.25 2.39232 0.34904 1 DataSet_02_189
SPP1 LMNB2 siRNA Haematopoietic_and_lymphoid_tissue K562 0.55263 -0.85561 0.78046 1 DataSet_02_191
SPP1 ARID3A siRNA Haematopoietic_and_lymphoid_tissue K562 2.06452 1.0458 0.42604 1 DataSet_02_193
SPP1 CDAN1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.17857 -2.48543 0.66866 1 DataSet_02_197
SPP1 UBTF siRNA Haematopoietic_and_lymphoid_tissue K562 5.33333 2.41504 0.08694 1 DataSet_02_198
SPP1 MAZ siRNA Haematopoietic_and_lymphoid_tissue K562 0.64516 -0.63227 0.55562 1 DataSet_02_199
SPP1 E2F4 siRNA Haematopoietic_and_lymphoid_tissue K562 0.18421 -2.44057 0.78798 1 DataSet_02_200
SPP1 TAL1 siRNA Haematopoietic_and_lymphoid_tissue K562 3.2 1.67807 0.8861 1 DataSet_02_201
SPP1 RCOR1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.08333 -3.58496 0.08885 1 DataSet_02_204
SPP1 E2F6 siRNA Haematopoietic_and_lymphoid_tissue K562 0.14286 -2.80735 0.5618 1 DataSet_02_205
SPP1 AR siRNA Prostate LNCaP 0.575949 -0.795986 0.24168140295282 1 DataSet_03_005
SPP1 ARID1A siRNA Mammary_gland MDA-MB-157 2.20934 1.14361 - - DataSet_03_014
SPP1 BATF3 siRNA Haematopoietic_and_lymphoid_tissue L428 1.50699 0.591673 0.000264916301282123 0.1684374211044 DataSet_03_022
SPP1 BCL6 siRNA Lymph Pfeiffer DLBCL 1.91114 0.934437 0.216751724582578 0.688941522946679 DataSet_03_026
SPP1 CASP8AP2 siRNA Bone_marrow hTERT-RPE1 1.56673 0.647756 0.0165424237993594 0.355997019652718 DataSet_03_030
SPP1 E2F7 siRNA Upper_aerodigestive_tract SCC25 1.54547 0.628044 2.62946776108607e-05 0.000403099621327329 DataSet_03_063
SPP1 EP300 siRNA Prostate LNCaP 0.515164 -0.956897 0.050212075692938 0.132325043883249 DataSet_03_065
SPP1 FOXD1 siRNA Skin Fibroblast 1.51447 0.59881 0.02288958822091 0.999830550306409 DataSet_03_085
SPP1 FOXO1 siRNA Skin primary human dermal lymphatic endothelial cells 0.335895 -1.57392 - - DataSet_03_096
SPP1 GATA4 siRNA Stomach AGS 1.98198 0.986939 0.0409429757110205 0.64256728687883 DataSet_03_105
SPP1 GATA4 siRNA Stomach KatoIII 0.49232 -1.02233 0.354704079148174 0.940515767478399 DataSet_03_106
SPP1 GATA6 siRNA Stomach AGS 3.38154 1.75768 0.00318124148396481 0.187072884817286 DataSet_03_108
SPP1 GATA6 siRNA Stomach KatoIII 1.5635 0.644778 0.497392793105145 0.864033445747787 DataSet_03_109
SPP1 HIC1 CRISPR Prostate PC3 0.0545911 -4.19519 - - DataSet_03_118
SPP1 HOXC4 siRNA Skin Fibroblast 1.56438 0.645594 3.90303417690193e-05 0.0143673179350171 DataSet_03_128
SPP1 HTATIP siRNA Prostate LNCaP 1.51675 0.600986 0.00489734641159691 0.0100423719240203 DataSet_03_131
SPP1 HTATIP2 siRNA Prostate LNCaP 3.09947 1.63202 0.214005196125679 0.248918430538932 DataSet_03_132
SPP1 IRF4 siRNA Skin Cutaneous T cell lymphoma HuT-102 cells 2.04794 1.03417 0.18085944500553 0.999948959532916 DataSet_03_134
SPP1 KLF5 siRNA Stomach KatoIII 2.24703 1.16802 0.241590380217175 0.686116679816777 DataSet_03_150
SPP1 KLF5 siRNA Stomach YCC3 2.28403 1.19158 5.88911431254452e-05 0.0172336176267772 DataSet_03_151
SPP1 MEF2D shRNA Liver HuH7 1.52328 0.60718 - - DataSet_03_162
SPP1 MEF2D siRNA Liver HuH7 0.422998 -1.24128 - - DataSet_03_163
SPP1 MITF siRNA Skin MZ7 0.297861 -1.74729 8.99872475834196e-15 1.78401003866238e-12 DataSet_03_165
SPP1 MITF siRNA Skin Ma-Mel-15 0.539556 -0.890156 0.048786903485163 0.412902738174897 DataSet_03_166
SPP1 MITF siRNA Skin SK-MEL-5 0.551036 -0.859782 0.000213847297300402 0.00100579978046485 DataSet_03_168
SPP1 MTA2 siRNA Stomach SGC-7901 0.417705 -1.25944 - - DataSet_03_169
SPP1 MYB siRNA Cord_Blood CD34+ progenitor cells 2.01514 1.01088 - - DataSet_03_170
SPP1 MYC siRNA Central_nervous_system DAOY M2.1 3.60828 1.85131 6.73160023519759e-09 3.44616555775896e-07 DataSet_03_178
SPP1 PHB shRNA Embryo Embryonic stem cells (ESCs) 3.81246 1.93072 9.81896883301445e-07 0.000151878407199234 DataSet_03_211
SPP1 PRRX1 siRNA Skin Fibroblast 1.86047 0.895666 0.00311926624720162 0.184196478697421 DataSet_03_216
SPP1 RELA siRNA Fibroblasts WI38 1.55178 0.633929 0.00657847556212149 0.046984083107447 DataSet_03_222
SPP1 SOX2 siRNA Embryo 2102Ep 0.644149 -0.634533 0.000296763152508041 0.00781554632753361 DataSet_03_242
SPP1 SOX2 siRNA Embryo NTera-2 0.587068 -0.7684 1.01498822348639e-05 0.00144085005066992 DataSet_03_243
SPP1 SOX2 CRISPR Seminoma-like TCam-2 0.0536387 -4.22058 6.91015850885405e-05 0.126172220520613 DataSet_03_244
SPP1 SOX2 siRNA Mammary_gland GSC-11 0.581245 -0.782781 7.98401925344944e-06 0.00226427757529399 DataSet_03_245
SPP1 SOX4 siRNA Haematopoietic_and_lymphoid_tissue ST1 0.159091 -2.65208 - - DataSet_03_246
SPP1 SP1 siRNA Mammary_gland MDA-MB-231 0.530954 -0.913341 0.129720600079204 0.413972819854456 DataSet_03_250
SPP1 STAT3 CRISPR Embryo hESC 0.571418 -0.807382 0.160002352594869 0.226740354266744 DataSet_03_258
SPP1 STAT3 siRNA Prostate LNCaP 3.17548 1.66697 0.00699628532643794 0.0173335170459819 DataSet_03_262
SPP1 TFAP2C siRNA Mammary_gland MCF7 1.92092 0.9418 0.199998266695714 0.55101303629716 DataSet_03_274
SPP1 TWIST2 siRNA Skin Fibroblast 2.2589 1.17562 1.27537533586579e-07 0.000311176473199843 DataSet_03_284
SPP1 ZHX2 shRNA Kidney 786-O 0.42897 -1.22105 0.00289084140707215 0.0274392113080779 DataSet_03_287
SPP1 SMAD2 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.428571 -1.22239 0.660732308466231 0.767102889743461 DataSet_04_018
SPP1 YBX1 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.264151 -1.92057 0.30610076219712 0.656728712182125 DataSet_04_022
SPP1 E4F1 CRISPR Liver HepG2 0.505922 -0.983014 0.0108163693510021 0.228131599260109 DataSet_04_028
SPP1 ERN1 CRISPR Liver HepG2 0.331826 -1.5915 9.92191879244838e-05 0.0399361943378574 DataSet_04_029
SPP1 PAN2 CRISPR Liver HepG2 2.23897 1.16284 0.000519287312677112 0.0821848765220944 DataSet_04_033
SPP1 SMAD4 CRISPR Liver HepG2 1.53753 0.620613 0.00251373699409436 0.0692618815275676 DataSet_04_035
SPP1 WRN shRNA Liver HepG2 0.531229 -0.912594 0.000562173094309985 0.12469553215757 DataSet_04_038
SPP1 YBX1 CRISPR Liver HepG2 0.17325 -2.52907 0.34258954890378 0.972884761036538 DataSet_04_039
SPP1 ZC3H8 shRNA Liver HepG2 0.0281733 -5.14953 2.95938586039747e-05 0.0489074663912503 DataSet_04_040
SPP1 ZNF574 CRISPR Liver HepG2 2.69997 1.43294 0.00326976491537186 0.0572035829135144 DataSet_04_041
SPP1 ACTN4 CRISPR Liver HepG2 0.0661929 -3.91718 2.18550986266482e-05 0.0290651341479898 DataSet_04_042
SPP1 DDX20 CRISPR Liver HepG2 0.54528 -0.874932 0.00013639118860702 0.0330231286484203 DataSet_04_043
SPP1 CHCHD3 CRISPR Liver HepG2 1.7192 0.781741 0.130104764670317 0.511080380173938 DataSet_04_067
SPP1 CNOT7 CRISPR Liver HepG2 0.630374 -0.665721 0.000225166288356889 0.0119002717587564 DataSet_04_045
SPP1 PAN2 CRISPR Liver HepG2 1.53753 0.620613 0.00040946203043221 0.0207574739247889 DataSet_04_066
SPP1 RIOK2 CRISPR Liver HepG2 0.559685 -0.837312 0.0056535186413567 0.944114636228534 DataSet_04_070
SPP1 ABT1 shRNA Liver HepG2 0.203541 -2.29661 5.06434990354944e-06 0.00103653451670955 DataSet_04_052
SPP1 CALR shRNA Liver HepG2 0.3509 -1.51087 2.52308538234659e-05 0.00206118680344586 DataSet_04_053
SPP1 CCAR1 shRNA Liver HepG2 1.54499 0.6276 0.00106227797729676 0.0172028822234293 DataSet_04_054
SPP1 DDX1 shRNA Liver HepG2 0.493395 -1.01918 0.00237452052066475 0.0644499304956713 DataSet_04_057
SPP1 PRPF6 shRNA Liver HepG2 2.97862 1.57465 1.90560055811007e-05 0.0210821866264412 DataSet_04_056
SPP1 YBX3 shRNA Liver HepG2 0.276357 -1.8554 0.000133543798273166 0.0279539922692366 DataSet_02_98
SPP1 CITED2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 14 3.80735 0.0686853156834167 0.258359269136035 DataSet_02_38
SPP1 HMGA1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.45283 -1.14296 0.443027476865783 0.775825389005284 DataSet_02_75
SPP1 HMGN3 CRISPRi Haematopoietic_and_lymphoid_tissue K562 12.3333 3.62449 0.263197495067512 0.725149508087263 DataSet_02_45
SPP1 LDB1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 3.33333 1.73697 0.626871714427183 0.779695700848097 DataSet_02_35
SPP1 NFE2L1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 15.6667 3.96963 0.0961951879921466 0.415089980903254 DataSet_02_32
SPP1 SMARCA4 CRISPRi Haematopoietic_and_lymphoid_tissue K562 2 1 0.785533453646058 0.877402029796075 DataSet_02_47
SPP1 TEAD2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 13.3333 3.73697 0.27746268055456 0.427429209177448 DataSet_02_33
SPP1 TLE2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 4.33333 2.11548 0.386873118475641 0.557310293442996 DataSet_02_53
SPP1 ABT1 shRNA Haematopoietic_and_lymphoid_tissue K562 2.77778 1.47393 0.262593511907518 0.42100423151176 DataSet_04_060
SPP1 CNOT7 shRNA Haematopoietic_and_lymphoid_tissue K562 9.6 3.26303 0.0620627766831569 0.191417656105726 DataSet_04_061
SPP1 EZH2 knockdown Uterus Ishikawa (ISK) cell 0.512081 -0.965555 - - DataSet_03_324
SPP1 SMARCA4 siRNA Colon HCT116 2.04573 1.03262 8.898672e-02 9.445320e-01 DataSet_03_301
SPP1 SMARCA4 siRNA Colon HCT116 0.29427 -1.76479 1.039790e-03 0.1301247 DataSet_03_302
SPP1 SNAI2 shRNA Pancreas pancreatic cancer stem cells 1.78591 0.836661 5.539068e-01 0.8066929 DataSet_03_306
SPP1 SNAI2 shRNA Pancreas KLM1 0.0609241 -4.03684 1.691230e-03 0.10791887 DataSet_03_307
SPP1 PRMT1 shRNA Lung A549 2.0149 1.01071 - - DataSet_03_342
SPP1 ACTR5 siRNA Muscle RD 0.489099 -1.0318 - - DataSet_03_343
SPP1 INO80 siRNA Muscle RD 2.15858 1.11008 - - DataSet_03_344
SPP1 BRCA1 siRNA Mammary_gland MCF7 1.62072 0.696639 7.391070e-01 0.9999931 DataSet_03_308
SPP1 LITAF siRNA Lymph KARPAS-231 2.52176 1.33443 1.587971e-03 0.26166169 DataSet_03_309
SPP1 EZH2 knockdown Colon HCT116 2.74996 1.45941 0.484374155 0.9791817 DataSet_03_334
SPP1 DNMT1 shRNA Lung hTERT-immortalised adult fibroblasts 1.94092 0.956743 2.203643e-01 7.509312e-01 DataSet_03_311
SPP1 TET1 CRISPR Mammary_gland MDA-MB-231 12.7804 3.67586 5.900413e-01 7.481923e-01 DataSet_03_347
SPP1 EZH2 shRNA Mammary_gland LM2 2.24437 1.16631 6.458080e-03 1.350408e-01 DataSet_03_350
SPP1 SKI CRISPR Blood HL60 1.9 0.925999 3.103592e-01 0.615851377 DataSet_03_351
SPP1 ESR1 siRNA Mammary_gland MCF7 2.07303 1.05174 3.069739e-01 0.4996772184 DataSet_03_352
SPP1 ETV5 knockdown Colon HT29 2.14286 1.09954 3.337230e-03 0.071095160 DataSet_03_353
SPP1 TET1 CRISPR Mammary_gland Hs578T 0.390624 -1.35615 2.113921e-01 3.957344e-01 DataSet_03_355
SPP1 CREBBP CRISPR Brain U5-NPC 1.50411 0.58891 0.8495596544 0.9099519 DataSet_03_356
SPP1 PTPN14 CRISPR Brain U5-NPC 0.296403 -1.75437 7.696630e-02 0.30275942 DataSet_03_357
SPP1 TP53 CRISPR Brain U5-NPC 1.88189 0.912182 1.567870e-01 2.921911e-01 DataSet_03_358
SPP1 RUNX1 shRNA Haematopoietic_and_lymphoid_tissue OCI-AML5 0.296854 -1.75217 1.562597e-02 1.677123e-01 DataSet_03_359
SPP1 MYC siRNA Peripheral_blood T lymphocyte 4.42956 2.14717 2.360432e-01 0.533622078 DataSet_03_363
SPP1 EP300 shRNA Mammary_gland MCF10AT 7.9375 2.98868 7.404411e-05 0.012250641 DataSet_03_364
SPP1 USP22 shRNA Liver PLC_PRF_5 cells 1.85714 0.893085 2.648319e-01 0.48634664 DataSet_03_368
SPP1 ZFP36L1 siRNA Urinary_bladder J82 7 2.80735 - - DataSet_03_371
SPP1 GLI1 siRNA Skeletal_muscle RMS13 5.37126 2.42526 9.760056e-03 0.074022861 DataSet_03_375
SPP1 EZH2 CRISPR Ovary SKOV3 7.97398 2.9953 4.017002e-06 0.0009335243 DataSet_03_378
SPP1 NFKB2 siRNA Bone_marrow U2OS 2.24956 1.16965 2.761240e-02 0.21838556 DataSet_03_381
SPP1 TCF19 CRISPR Oral_squamous CAL27 0.309261 -1.6931 5.398009e-03 0.0512645148 DataSet_03_383
SPP1 YY1 shRNA Brain GSC23 1.73414 0.794224 - - DataSet_03_385
SPP1 KAT6A CRISPR Haematopoietic_and_lymphoid_tissue MOLM-13 13.0023 3.70069 0.3364639246 0.8453032 DataSet_03_387
SPP1 YY1 knockdown Liver HepG2 2.09314 1.06567 1.649013e-05 1.560606e-04 DataSet_03_390
SPP1 KDM5A CRISPR Lung GLC16 3.77266 1.91558 2.304566e-03 0.021258943 DataSet_03_392
SPP1 ASXL1 CRISPR Embryo iPSC 0.641727 -0.639968 0.9618664994 0.9920679 DataSet_03_394
SPP1 BMI1 shRNA Bile_duct QBC-939 3.45323 1.78795 1.014192e-05 0.0007778981 DataSet_03_395
SPP1 IKZF2 CRISPR Lymph CAR T Cell 1.56973 0.65052 3.282978e-01 0.755686565 DataSet_03_397
SPP1 RELA CRISPR Brain T30 0.559956 -0.836615 0.6123285422 0.8843788 DataSet_03_399
SPP1 HMGA1 shRNA Bile_duct HUCCT1 2.5 1.32193 1.759250e-03 0.050303715 DataSet_03_400
SPP1 SUMO1 CRISPR Bone_marrow U2OS 0.42236 -1.24345 1.435966e-05 9.837787e-04 DataSet_03_401
SPP1 EHF shRNA Stomach MKN7 0.000992266 -9.97699 - - DataSet_03_402
SPP1 JARID2 siRNA Adipose_tissue human adipose tissue derived stem cells 1.65347 0.725493 4.356466e-01 0.5747889 DataSet_03_403
SPP1 TFAP2A knockout Embryo H9 6.46111 2.69178 3.536277e-04 0.02000360 DataSet_03_405
SPP1 MAP3K7 shRNA Prostate LNCaP 1.57143 0.652077 3.390334e-01 5.695154e-01 DataSet_03_408
SPP1 STRAP knockout Nerve SK-N-AS 0.0858632 -3.54182 - - DataSet_03_409
SPP1 USP22 shRNA Liver HuH7 3.05857 1.61286 - - DataSet_03_411
SPP1 RUNX2 shRNA Cord_blood Natural Killer Cell 0.128205 -2.96347 2.153522e-02 0.793390621 DataSet_03_416
SPP1 FOXK2 shRNA Ovary OVCAR-5 5.63636 2.49477 1.143019e-02 0.09617284 DataSet_03_419
SPP1 PRDM1 CRISPR Lymph CD8+ T cells 1.6 0.678072 - - DataSet_03_421
SPP1 FOXP3 CRISPR Peripheral_blood Naive Treg 0.648379 -0.625091 3.782044e-01 0.692612148 DataSet_03_427
SPP1 LHX2 shRNA Bone_marrow ES-derived RPE cells 2.01695 1.01217 1.704171e-01 1.000000e+00 DataSet_03_428
SPP1 USP7 shRNA Skin xenograft cells 0.398409 -1.32768 0.26705920 0.4348960 DataSet_03_431
SPP1 PLAG1 shRNA Cord_blood Lin-CD34+ HSPCs 2.2766 1.18688 - - DataSet_03_432
SPP1 POU2AF1 CRISPR Haematopoietic_and_lymphoid_tissue OCI-Ly7 0.5 -1 5.146796e-01 0.697670687 DataSet_03_434
SPP1 EP300 knockout Pancreas HPAF-II orthotopic cells 0.0115319 -6.43823 1.960117e-05 5.726156e-04 DataSet_03_436
SPP1 SUFU shRNA Mammary_gland HCC1954 cells 0.156164 -2.67886 0.0563485109 0.5458359 DataSet_03_437
SPP1 CIC knockout Brain Immortalized Astrocyte Cells 6.93548 2.794 5.456834e-02 4.000036e-01 DataSet_03_438
SPP1 FOXA2 CRISPR Liver iPSCs-derived progenitors and mature hepatocytes 10.3194 3.36729 2.027669e-05 0.06471797 DataSet_03_439
SPP1 HMG20A siRNA Mammary_gland MDA-MB-231 2 1 0.2979821882 0.4905665 DataSet_03_442
SPP1 RELB CRISPR Colon SW480 8 3 4.588601e-02 1.853646e-01 DataSet_03_449
SPP1 CBX2 siRNA Mammary_gland MDA-MB-231 0.149942 -2.73752 1.530639e-01 3.280329e-01 DataSet_03_450
SPP1 CBX2 siRNA Mammary_gland MCF7 1.93251 0.950478 7.417264e-01 0.8457818537 DataSet_03_451
SPP1 ZFP36L1 CRISPR Lung NCI-H1876 0.567663 -0.816893 1.565077e-01 0.992381486 DataSet_03_454
SPP1 SMARCA2 shRNA Lung HCC2302 0.066204 -3.91694 1.109055e-07 3.715617e-07 DataSet_03_455
SPP1 ARID1A shRNA Bile_duct MMNK1 0.605915 -0.722813 5.894909e-01 0.764612329 DataSet_03_458
SPP1 HAND1 siRNA Placenta HPMVEC 5.25 2.39232 1.832252e-01 0.9463341 DataSet_03_459
SPP1 IRF2 shRNA Cord_Blood CD34+ cells 2.63782 1.39935 - - DataSet_03_460
SPP1 TXNIP shRNA Cord_blood ST3 2.53933 1.34445 1.476225e-01 0.4406971418 DataSet_03_462
SPP1 SOX9 knockout Liver HuH7 0.503038 -0.991262 8.184877e-04 7.919328e-03 DataSet_03_463
SPP1 PARP1 knockout Embryo_kidney HEK293a 3.75 1.90689 2.142503e-03 8.814914e-03 DataSet_03_464
SPP1 SMARCA1 Cas13 Embryo_kidney HEK293T 9 3.16992 - - DataSet_03_466
SPP1 SMARCA1 CRISPR-Csm Embryo_kidney HEK293T 6 2.58496 - - DataSet_03_467
SPP1 SMARCA1 shRNA Embryo_kidney HEK293T 2 1 - - DataSet_03_468
SPP1 CHCHD3 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.6 -0.736966 0.4844146 0.9443437 DataSet_04_071
SPP1 APTX CRISPR Haematopoietic_and_lymphoid_tissue K562 5.88889 2.558 0.03064404 0.4226185 DataSet_04_072
Regulation Region
 
T(co)Fs that significantly regulate TAF15 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of SPP1
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines