Gene Overview
Target Gene: TXNIP
NCBI Official Symbol: TXNIP
Entrez ID: 10628
Ensembl ID: ENSG00000265972
Gene Full Name: thioredoxin interacting protein
Strand: +
Gene Locus: 1q21.1
External Links:

TXNIP Significantly Regulated by These T(co)Fs

T(co)Fs that Activate TXNIP   
T(co)Fs that Repress TXNIP
The Intensity of the Gene Regulated by T(co)Fs:
TXNIP-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
TXNIP HNF1B shRNA Ovary RMG2 0.6385 -0.64725 1.57921e-05 0.00013 DataSet_01_103
TXNIP HSF1 siRNA Upper_aerodigestive_tract HSC3 1.80968 0.85574 0.01814 0.14922 DataSet_01_112
TXNIP ID1 siRNA Lung A549 2.28539 1.19244 0.01709 0.16572 DataSet_01_117
TXNIP GATA3 siRNA Mammary_gland MCF7 1.75319 0.80998 5.00461e-06 0.00041 DataSet_01_120
TXNIP ZIC2 siRNA Pancreas PANC1 3.03738 1.60283 - - DataSet_01_121
TXNIP FOXM1 siRNA Central_nervous_system U87 10.9702 3.45552 - - DataSet_01_122
TXNIP NFYA shRNA Cervix HeLaS3 1.9819 0.98688 1.77454e-06 0.00051 DataSet_01_131
TXNIP ID1 shRNA Neuroepithelium GSC8 0.29678 -1.75254 5.31141e-13 1.6094e-11 DataSet_01_134
TXNIP SPDEF shRNA Mammary_gland MCF7 0.54993 -0.86268 5.11847e-05 0.01036 DataSet_01_135
TXNIP IKZF2 shRNA Haematopoietic_and_lymphoid_tissue JURKAT 6.40464 2.67912 4.18929e-06 0.00128 DataSet_01_137
TXNIP POLR3A siRNA Mammary_gland MCF7 0.32705 -1.61241 - - DataSet_01_139
TXNIP SOX4 shRNA Parotid_gland ACC3 1.56893 0.64978 0.1163 0.95439 DataSet_01_140
TXNIP TFAP2C shRNA Mammary_gland MCF7 4.05083 2.01822 0.00014 0.00047 DataSet_01_150
TXNIP TAL1 shRNA Umbilical_cord_blood ECFCs 3.06612 1.61641 0.13278 0.66712 DataSet_01_152
TXNIP HSF1 shRNA Skin A375 2.04315 1.0308 0.00041 0.00654 DataSet_01_155
TXNIP MYCN siRNA Autonomic_ganglia SKNBE2 2.35713 1.23703 0.00017 0.05014 DataSet_01_160
TXNIP ELK1 siRNA Peripheral_blood CD4+ T cells 0.61208 -0.70821 0.49746 0.70817 DataSet_01_162
TXNIP JUN siRNA Peripheral_blood CD4+ T cells 0.33127 -1.59391 0.45305 0.69559 DataSet_01_164
TXNIP MAF siRNA Peripheral_blood CD4+ T cells 0.31547 -1.66443 0.40183 0.74473 DataSet_01_165
TXNIP NFKB1 siRNA Peripheral_blood CD4+ T cells 1.59664 0.67504 0.35574 0.81661 DataSet_01_167
TXNIP STAT3 siRNA Peripheral_blood CD4+ T cells 0.00087 -10.1684 0.06291 0.99183 DataSet_01_168
TXNIP HOXB7 siRNA Pancreas MIA PaCa-2 1.5279 0.61155 0.0596 0.61937 DataSet_01_169
TXNIP FOSL1 siRNA Mammary_gland BT549 0.3761 -1.41081 8.22838e-11 4.7318e-08 DataSet_01_171
TXNIP JUN siRNA Mammary_gland BT549 0.61549 -0.70019 0.00375 0.1288 DataSet_01_172
TXNIP TP63 shRNA Bladder UC14 3.95074 1.98212 6.20362e-07 4.95824e-05 DataSet_01_183
TXNIP STAT3 siRNA Urothelial Scaber 2.40277 1.2647 0.01029 0.06781 DataSet_01_184
TXNIP TCF4 siRNA Autonomic_ganglia SH-SY5Y 1.95814 0.96949 0.00201 0.04066 DataSet_01_185
TXNIP AR siRNA Prostate R1-D567 1.52214 0.6061 0.0242 0.29579 DataSet_01_192
TXNIP GATA2 siRNA Prostate LNCaP 0.41127 -1.28185 0.00022 0.00187 DataSet_01_193
TXNIP XBP1 shRNA Mammary_gland MDA-MB-231 1.51193 0.59639 0.00109 0.01825 DataSet_01_204
TXNIP ATF2 siRNA Haematopoietic_and_lymphoid_tissue K562 2.39248 1.2585 0.34971 0.98802 DataSet_01_206
TXNIP MITF shRNA Skin COLO829 1.56821 0.64912 0.00595 0.06335 DataSet_01_207
TXNIP REST siRNA Prostate LNCaP 0.65819 -0.60341 0.02423 0.21235 DataSet_01_211
TXNIP EGR3 shRNA Prostate M12 1.55968 0.64125 0.01118 0.12153 DataSet_01_212
TXNIP LIN28A siRNA Embryo H9 8.65039 3.11276 4.78986e-06 0.00054 DataSet_01_215
TXNIP TAL1 shRNA Haematopoietic_and_lymphoid_tissue HEL 0.65459 -0.61134 0.00175 0.01881 DataSet_01_217
TXNIP ATM shRNA Mammary_gland MCF10A 0.21345 -2.22804 5.64447e-09 4.31363e-07 DataSet_01_219
TXNIP SNAI2 shRNA Skin Primary human keratinocytes 4.06339 2.02268 4.12583e-05 0.00602 DataSet_01_225
TXNIP IRX1 shRNA Bone_marrow 143B 0.23981 -2.06005 0.00241 0.05418 DataSet_01_227
TXNIP MYC siRNA White_adipose_tissue Adipose stem cells 2.66818 1.41586 2.50461e-07 9.34527e-05 DataSet_01_231
TXNIP FOXA1 siRNA Prostate LNCaP 5.4158 2.43717 0.03876 0.28953 DataSet_01_233
TXNIP FOXP1 siRNA Prostate LNCaP 5.88819 2.55782 0.03056 0.35198 DataSet_01_234
TXNIP TWIST1 shRNA Stomach CAF32 23.5215 4.55591 3.69924e-06 0.01138 DataSet_01_253
TXNIP TWIST1 shRNA Stomach CAF 5.51162 2.46248 0.07535 0.5711 DataSet_01_254
TXNIP YBX1 shRNA Mammary_gland MDA-LM2 1.59582 0.6743 0.0122 0.11835 DataSet_01_256
TXNIP YBX1 shRNA Mammary_gland MDA 1.60579 0.68328 5.72179e-06 0.00359 DataSet_01_258
TXNIP NFKB2 siRNA Haematopoietic_and_lymphoid_tissue L-1236 1.60141 0.67935 0.01102 0.24465 DataSet_01_261
TXNIP SIX4 siRNA Ovary PEO1 3.12975 1.64605 1.44036e-05 0.00142 DataSet_01_269
TXNIP FOXO1 siRNA Umbilical_vein HUVEC 3.25046 1.70064 4e-04 0.01149 DataSet_01_270
TXNIP SALL4 shRNA Lung H661 0.06075 -4.04106 3.55159e-05 0.01123 DataSet_01_277
TXNIP MSX1 siRNA Tooth Dental Pulp Cells 0.61116 -0.71038 2e-04 0.00164 DataSet_01_281
TXNIP ZIC5 siRNA Skin A375 2.87938 1.52576 - - DataSet_01_284
TXNIP TP53 shRNA Haematopoietic_and_lymphoid_tissue JVM2 0.15621 -2.67846 6.13662e-08 2.75827e-06 DataSet_01_286
TXNIP POSTN shRNA Brain GSC272 1.56028 0.6418 0.30316 0.65108 DataSet_01_293
TXNIP TFAP4 siRNA Brain BE(2)-C 0.14682 -2.76783 0.26093 0.51625 DataSet_01_295
TXNIP MYCN siRNA Brain BE(2)-C 1.83252 0.87383 0.96058 1 DataSet_01_296
TXNIP PTEN shRNA Skin A431 5.89118 2.55856 9.40591e-05 0.0655 DataSet_01_301
TXNIP HOXA5 shRNA Mammary_gland MCF10A 1.84132 0.88074 0.04802 0.78679 DataSet_01_305
TXNIP SOX9 siRNA Prostate VCaP 0.49283 -1.02083 0.13325 0.9316 DataSet_01_308
TXNIP SOX9 siRNA Prostate VCaP 0.49283 -1.02083 0.13325 0.9316 DataSet_01_309
TXNIP BRD4 siRNA Ovary Ovcar8 3.16601 1.66266 0.01266 0.04763 DataSet_01_311
TXNIP OVOL2 siRNA Corneal_epithelial Corneal epithelial cells 2.89181 1.53197 0.0626 0.33458 DataSet_01_313
TXNIP ERG siRNA Cervix HeLa 4.19756 2.06955 7.84103e-10 1.19655e-08 DataSet_01_316
TXNIP ELK3 shRNA Mammary_gland MDA-MB-231 0.26785 -1.9005 1.71971e-06 4.6865e-05 DataSet_01_318
TXNIP ZNF25 siRNA Bone_marrow hMSC-TERT4 1.66726 0.73748 0.05082 0.49735 DataSet_01_319
TXNIP GRHL3 siRNA Skin NHEK 1.64507 0.71815 0.10628 0.57004 DataSet_01_336
TXNIP KLF4 siRNA Embryo HCE 1.8241 0.86718 0.01896 0.41743 DataSet_01_341
TXNIP ARID1A shRNA Uterus iEEC16 1.93682 0.95369 - - DataSet_01_345
TXNIP GATA3 siRNA Oral_cavity OEC-M1 0.64163 -0.64019 0.2793 0.99787 DataSet_01_347
TXNIP HIF1A siRNA Oral_cavity OEC-M1 0.48061 -1.05708 0.12578 0.85151 DataSet_01_348
TXNIP SOX2 shRNA Neuroepithelium HF2303 0.55914 -0.83871 0.10305 1 DataSet_01_349
TXNIP SMAD2 siRNA Pancreas BxPC-3 0.6524 -0.61618 - - DataSet_01_351
TXNIP SOX17 siRNA Umbilical_vein HUVEC 2.59816 1.37749 - - DataSet_01_360
TXNIP GTF2B siRNA Cervix HeLa 2.22331 1.15271 - - DataSet_01_362
TXNIP FIP1L1 shRNA Liver HepG2 1.82842 0.8706 0.00303 0.0229 DataSet_02_103
TXNIP HDGF shRNA Liver HepG2 2.34873 1.23188 0.00053 0.06383 DataSet_02_104
TXNIP U2AF2 shRNA Liver HepG2 0.62107 -0.68717 0.18435 0.32356 DataSet_02_105
TXNIP SSB shRNA Liver HepG2 0.0503 -4.31328 4.86275e-05 0.00352 DataSet_02_107
TXNIP GTF2F1 shRNA Liver HepG2 1.76146 0.81677 0.0038 0.20753 DataSet_02_110
TXNIP RBM39 shRNA Liver HepG2 0.58905 -0.76353 0.04595 0.24884 DataSet_02_111
TXNIP TARDBP shRNA Liver HepG2 1.50344 0.58827 0.02122 0.05805 DataSet_02_116
TXNIP SUB1 shRNA Liver HepG2 1.51372 0.5981 0.012 0.14015 DataSet_02_117
TXNIP EWSR1 shRNA Liver HepG2 0.54919 -0.86463 0.004 0.04665 DataSet_02_122
TXNIP FUS shRNA Liver HepG2 2.04901 1.03493 0.00154 0.05252 DataSet_02_124
TXNIP SNRNP70 shRNA Liver HepG2 4.2957 2.10289 0.00037 0.03074 DataSet_02_126
TXNIP SRSF3 shRNA Liver HepG2 1.64145 0.71497 0.0133 0.09107 DataSet_02_127
TXNIP PRPF4 shRNA Liver HepG2 0.47579 -1.07161 0.00035 0.02482 DataSet_02_128
TXNIP PTBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.44257 -1.17601 0.0069 0.03986 DataSet_02_131
TXNIP AGO2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.35542 -1.49242 0.00378 0.09503 DataSet_02_132
TXNIP TAF15 shRNA Haematopoietic_and_lymphoid_tissue K562 1.51612 0.60039 0.2207 0.45629 DataSet_02_140
TXNIP FIP1L1 shRNA Haematopoietic_and_lymphoid_tissue K562 1.56313 0.64444 0.01848 0.10337 DataSet_02_147
TXNIP RBM39 shRNA Haematopoietic_and_lymphoid_tissue K562 1.51476 0.59909 0.04237 0.24786 DataSet_02_151
TXNIP AGO1 shRNA Haematopoietic_and_lymphoid_tissue K562 1.53018 0.6137 0.01867 0.53443 DataSet_02_162
TXNIP ZFX siRNA Prostate C4-2B 2.01131 1.00813 1.11995e-05 0.00072 DataSet_02_172
TXNIP RAD21 siRNA Haematopoietic_and_lymphoid_tissue K562 1.74757 0.80535 0.48373 1 DataSet_02_190
TXNIP AR siRNA Prostate LNCaP 1.9769 0.983239 0.000523429646410992 0.000953566627136744 DataSet_03_011
TXNIP ARID1A siRNA Oral_cavity SAS cells 1.68684 0.754323 0.557482619553868 0.824061028827408 DataSet_03_013
TXNIP ARID2 CRISPR Liver JHH4 1.77645 0.828996 0.0975010899111518 1 DataSet_03_015
TXNIP ATF4 siRNA Skin A375 1.84113 0.880588 0.282702645377259 0.775512819201899 DataSet_03_018
TXNIP BCL6 siRNA Mammary_gland MCF7 0.546318 -0.872188 0.00681517961941209 0.989541443114508 DataSet_03_024
TXNIP CASP8AP2 siRNA Bone_marrow U2OS 2.00827 1.00595 0.00160784789264094 0.026925201068999 DataSet_03_031
TXNIP CCNA2 siRNA Mammary_gland MCF7 0.652559 -0.615819 0.0304855450880274 0.872422373040044 DataSet_03_034
TXNIP CEBPD siRNA Mammary_gland MCF7 0.544254 -0.877647 0.00661518894902547 0.999848455332859 DataSet_03_050
TXNIP CREBBP siRNA Mammary_gland MCF7 0.551088 -0.859645 0.00730042369634679 0.963067261754673 DataSet_03_055
TXNIP CTCF siRNA Prostate LNCaP 2.05639 1.04012 0.0708705869012037 0.482465149288963 DataSet_03_056
TXNIP E2F7 siRNA Upper_aerodigestive_tract SCC25 2.21243 1.14563 8.50110968247269e-05 0.000999111396105826 DataSet_03_063
TXNIP EP300 siRNA Prostate LNCaP 0.627261 -0.672862 0.128467178838261 0.24205479862674 DataSet_03_065
TXNIP ERBB2 siRNA Mammary_gland MCF7 0.619995 -0.689671 0.0194273719337447 0.998282799776643 DataSet_03_066
TXNIP ESR1 siRNA Mammary_gland MCF7 1.87868 0.909716 0.26460535407464 0.294635348361892 DataSet_03_071
TXNIP ETS1 siRNA Fibroblasts WI38 1.53776 0.620833 0.273810678228195 0.499380386740801 DataSet_03_074
TXNIP FOXC1 siRNA Mammary_gland MCF7 0.477375 -1.06681 0.00249060987173536 0.999669928105298 DataSet_03_084
TXNIP FOXF2 siRNA Mammary_gland MCF10A 2.23725 1.16172 - - DataSet_03_086
TXNIP FOXF2 siRNA Mammary_gland MDA-MB-231 2.05078 1.03617 - - DataSet_03_087
TXNIP GATA2 siRNA Lymph Lymphatic endothelial cells 0.474157 -1.07656 4.38415652961408e-06 0.000111619378564393 DataSet_03_101
TXNIP GATA3 siRNA Mammary_gland MCF7 0.569751 -0.811597 0.00954338432316224 0.999831535534034 DataSet_03_102
TXNIP GATA3 siRNA Mammary_gland MCF7 7.13209 2.83432 0.0482702186326227 0.176631019409512 DataSet_03_103
TXNIP GATA4 siRNA Stomach YCC3 0.205182 -2.28502 0.000975239052940951 0.324904641406712 DataSet_03_107
TXNIP GRHL3 siRNA Skin Primary neonatal keratinocytes 2.02885 1.02066 0.0794458159247282 0.330348504536831 DataSet_03_113
TXNIP HIC1 CRISPR Prostate PC3 0.541812 -0.884137 - - DataSet_03_118
TXNIP HIF3A siRNA Liver Hep3B 0.35233 -1.505 0.00538584967681545 1 DataSet_03_120
TXNIP HIF3A siRNA Liver Hep3B 0.35233 -1.505 0.00538584967681545 1 DataSet_03_121
TXNIP HINFP siRNA Bone_marrow hTERT-RPE1 1.53557 0.61877 0.00044254941615945 0.054445454021223 DataSet_03_122
TXNIP HINFP siRNA Bone_marrow U2OS 2.44384 1.28915 0.000444523966512899 0.0188044194324817 DataSet_03_123
TXNIP HMGA1 siRNA Mammary_gland MDA-MB-231 1.63599 0.71016 9.36627324713689e-07 2.54487637599434e-05 DataSet_03_124
TXNIP JARID1A siRNA Autonomic_ganglia SKNBE2 1.74322 0.801759 0.115383920247998 0.518405520401947 DataSet_03_135
TXNIP JUN siRNA Mammary_gland MCF7 0.523564 -0.933562 0.0529826934148658 0.999857657786768 DataSet_03_142
TXNIP Klf4 siRNA Skin Primary neonatal keratinocytes 0.645348 -0.631851 0.332190859417392 0.518980813843419 DataSet_03_147
TXNIP KLF5 siRNA Stomach KatoIII 0.633717 -0.65809 0.00126333639895604 0.11120955170485 DataSet_03_150
TXNIP KLF5 siRNA Stomach YCC3 0.143728 -2.79858 1.51150124815013e-05 0.0111684797535663 DataSet_03_151
TXNIP MAFB siRNA Peripheral_blood Monocyte-derived M-CSF macrophages 1.65864 0.73 0.0654991429248862 1 DataSet_03_155
TXNIP MAX siRNA Mammary_gland MCF7 0.622162 -0.684637 0.0200242957958312 0.999907009675999 DataSet_03_158
TXNIP MEF2D shRNA Liver HuH7 1.65139 0.723685 - - DataSet_03_162
TXNIP MEF2D siRNA Liver HuH7 2.68127 1.42291 - - DataSet_03_163
TXNIP MITF siRNA Skin MZ7 4.3384 2.11716 1.44454426417754e-15 3.91539208604496e-13 DataSet_03_165
TXNIP MITF siRNA Skin Ma-Mel-15 11.6227 3.53888 8.05721280287826e-07 0.00136257203122903 DataSet_03_166
TXNIP MITF siRNA Skin Ma-Mel-15 11.3739 3.50765 5.51634589208032e-09 8.6972715278499e-06 DataSet_03_167
TXNIP MITF siRNA Skin SK-MEL-5 1.51839 0.602547 0.00934549055533776 0.0201844365028124 DataSet_03_168
TXNIP MYB siRNA Cord_Blood CD34+ progenitor cells 2.60285 1.38009 - - DataSet_03_170
TXNIP MYB siRNA Prostate VCaP 0.495973 -1.01167 0.000611008087511832 0.0334526927912728 DataSet_03_174
TXNIP MYCN siRNA Autonomic_ganglia SKNBE2 2.35713 1.23703 0.000161940414539282 0.0507261591185134 DataSet_03_185
TXNIP MYCN siRNA Brain BE(2)C cells 1.66019 0.73135 - - DataSet_03_188
TXNIP NFAT5 siRNA Synovial Primary fibroblast-like synoviocytes 1.82504 0.867931 0.180431013595211 0.58355512520717 DataSet_03_194
TXNIP NPAT siRNA Bone_marrow U2OS 2.18119 1.12512 2.53860914805363e-05 0.00420044017431252 DataSet_03_201
TXNIP NR4A3 siRNA Pancreas 1.1B4 1.77238 0.82569 0.0335844365607953 0.0786595279696333 DataSet_03_203
TXNIP PBX1 siRNA Mammary_gland LTED 1.87461 0.906591 0.00271685576709743 0.99990029707784 DataSet_03_208
TXNIP PBX1 siRNA Mammary_gland MCF7 1.99449 0.996019 5.63301481735628e-07 0.00058175797137747 DataSet_03_209
TXNIP PRRX1 CRISPR Neuroblastoma 691-MES 0.361193 -1.46916 0.0153889030545333 0.89189998148014 DataSet_03_217
TXNIP SATB1 siRNA Peripheral_blood CD4+ T cells 1.53776 0.62083 0.0621462545132933 0.999960966858709 DataSet_03_231
TXNIP SOX2 CRISPR Seminoma-like TCam-2 5.00407 2.3231 0.0104475448557483 0.999580851453413 DataSet_03_244
TXNIP SOX4 siRNA Haematopoietic_and_lymphoid_tissue ST1 0.592792 -0.754403 - - DataSet_03_246
TXNIP SOX9 knockdown Liver HepG2 0.123058 -3.02259 4.40060573448656e-09 1.51730990667161e-05 DataSet_03_248
TXNIP SP1 siRNA Mammary_gland MDA-MB-231 0.249781 -2.00127 0.174808772675773 0.415000680873834 DataSet_03_250
TXNIP SP1 siRNA Ovary OVSAYO 8.34246 3.06047 0.00295371128795978 0.0893305424592921 DataSet_03_251
TXNIP SRF siRNA Prostate LNCaP 2.59252 1.37435 0.0564862348042735 0.217055021926939 DataSet_03_254
TXNIP STAT1 knockout Liver Huh-7.5 0.597824 -0.742207 0.00280187228164119 0.0595474506830634 DataSet_03_257
TXNIP STAT6 siRNA Umbilical_vein HUVEC 0.490921 -1.02644 0.0887948354040809 0.80001815811535 DataSet_03_264
TXNIP TBX3 siRNA Skin Fibroblast 1.51507 0.599383 0.000105017195996471 0.00492385503505405 DataSet_03_265
TXNIP TET2 siRNA Embryo NCCIT 1.88717 0.916225 2.24700969632795e-05 0.00124692988076942 DataSet_03_270
TXNIP TET2 siRNA Prostate DU145 2.56047 1.35641 - - DataSet_03_271
TXNIP TET3 siRNA Embryo NCCIT 1.54823 0.63062 0.000257124108495192 0.00713244047995293 DataSet_03_273
TXNIP TP53 knockout Haematopoietic_and_lymphoid_tissue MM1S 0.547343 -0.869484 0.234898923379543 0.994828053448528 DataSet_03_279
TXNIP TP63 siRNA Skin Primary neonatal keratinocytes 3.63547 1.86214 0.0019467998912951 0.0159931531282229 DataSet_03_281
TXNIP TP63 siRNA Foreskin Neonatal foreskin keratinocytes 1.75641 0.812632 0.0308953704551417 0.729684006943091 DataSet_03_282
TXNIP TWIST1 siRNA Bone_marrow MSCs 5.10606 2.35221 - - DataSet_03_283
TXNIP ZNF750 siRNA Skin Primary neonatal keratinocytes 8.93708 3.1598 0.000600900010034163 0.0256899072315729 DataSet_03_294
TXNIP CIZ1 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.237819 -2.07206 0.00010315215074788 0.018311055901814 DataSet_04_004
TXNIP FUBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 1.60969 0.686782 0.0448763157273457 0.124691043855941 DataSet_04_010
TXNIP SMAD4 CRISPR Haematopoietic_and_lymphoid_tissue K562 6.43662 2.6863 6.5230857704337e-05 0.0979887211869635 DataSet_04_019
TXNIP ZNF574 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.570165 -0.810549 0.00472044120469082 0.113567209536072 DataSet_04_023
TXNIP ANXA2 CRISPR Liver HepG2 2.15594 1.10832 0.383668294978519 0.80513582707642 DataSet_04_024
TXNIP ACTN4 CRISPR Liver HepG2 0.258494 -1.95179 0.000234735853464928 0.0297664030747344 DataSet_04_042
TXNIP ABT1 shRNA Liver HepG2 2.44007 1.28692 6.24328925811595e-05 0.00210706197999587 DataSet_04_052
TXNIP UBE2L3 shRNA Liver HepG2 2.26969 1.18249 9.18789190341161e-05 0.00592914051821993 DataSet_04_055
TXNIP NPM1 CRISPR Haematopoietic_and_lymphoid_tissue K562 3.7278 1.89832 1.58479629452947e-05 0.0340600577442938 DataSet_04_046
TXNIP ABT1 shRNA Haematopoietic_and_lymphoid_tissue K562 1.82873 0.870845 0.00798043822576075 0.0468461643813945 DataSet_04_060
TXNIP ZNF830 shRNA Embryo_kidney HEK293T 2.37917 1.25046 8.024255e-02 0.4046280218 DataSet_03_315
TXNIP NFKBIZ knockout Colon Colon organoid 0.578867 -0.788697 3.323631e-03 0.403917646 DataSet_03_323
TXNIP NSD2 shRNA Haematopoietic_and_lymphoid_tissue K562 3.15335 1.65689 1.691625e-10 3.230874e-07 DataSet_03_303
TXNIP SNAI2 shRNA Pancreas pancreatic cancer stem cells 1.79431 0.843429 2.487534e-02 0.6279811 DataSet_03_306
TXNIP INO80 siRNA Muscle RD 0.330378 -1.59781 - - DataSet_03_344
TXNIP PBX1 siRNA Mammary_gland MCF7 1.99449 0.996018 7.483080e-07 6.681961e-04 DataSet_03_326
TXNIP EZH2 siRNA Prostate abl cells 1.62706 0.702266 0.0360107118 0.9999335 DataSet_03_327
TXNIP EZH2 siRNA Prostate abl cells 1.62706 0.702266 0.0360107118 0.9999335 DataSet_03_329
TXNIP LITAF siRNA Lymph KARPAS-231 1.55231 0.634421 1.792778e-02 0.37019259 DataSet_03_309
TXNIP EZH2 shRNA Mammary_gland MCF7 1.5002 0.585155 4.753704e-03 8.182118e-02 DataSet_03_331
TXNIP EZH2 knockdown Colon HCT116 2.22695 1.15507 0.039279737 0.8488990 DataSet_03_334
TXNIP DNMT1 shRNA Lung hTERT-immortalised adult fibroblasts 2.71281 1.43979 3.859390e-01 8.429953e-01 DataSet_03_311
TXNIP ARID3B CRISPR Colon HCT15 0.213862 -2.22525 - - DataSet_03_335
TXNIP TET1 CRISPR Mammary_gland MDA-MB-231 0.354228 -1.49725 7.750438e-05 2.266923e-03 DataSet_03_347
TXNIP ZFX siRNA Prostate C4-2B 2.04811 1.03429 9.820038e-08 1.673621e-05 DataSet_03_348
TXNIP ETV5 knockdown Colon HT29 7.61931 2.92966 4.601805e-04 0.038337423 DataSet_03_353
TXNIP ARID2 shRNA Haematopoietic_and_lymphoid_tissue MM.1S 1.62252 0.698235 5.038444e-05 3.547777e-04 DataSet_03_362
TXNIP TP53 knockout Stomach SNU1 0.456221 -1.1322 0.1495798921 0.9301241 DataSet_03_365
TXNIP USP22 shRNA Liver PLC_PRF_5 cells 0.197819 -2.33774 5.451402e-03 0.09492635 DataSet_03_368
TXNIP DNMT3A knockout Embryo_kidney HEK293T 384.72 8.58766 - - DataSet_03_369
TXNIP BHLHE40 shRNA Cervix HeLaS3 3.46573 1.79316 4.628511e-04 0.11917197 DataSet_03_372
TXNIP E2F1 siRNA Nasopharynx HK1 1.77366 0.826733 7.422279e-05 3.334291e-03 DataSet_03_373
TXNIP HNRNPU siRNA Colon RKO 1.65729 0.728827 - - DataSet_03_374
TXNIP GLI1 siRNA Skeletal_muscle RMS13 0.600339 -0.736151 1.140373e-02 0.081036234 DataSet_03_375
TXNIP ZNF213 siRNA Mammary_gland MCF7 563.151 9.13738 1.251394e-07 2.482279e-05 DataSet_03_376
TXNIP EZH2 CRISPR Ovary SKOV3 2.09348 1.0659 2.827351e-03 0.0372709397 DataSet_03_378
TXNIP DDX5 shRNA Stomach HGC-27 8.92045 3.15712 - - DataSet_03_379
TXNIP NFKB2 siRNA Bone_marrow U2OS 0.108434 -3.20511 1.486193e-05 0.02886026 DataSet_03_381
TXNIP YY1 shRNA Brain GSC3028 1.56833 0.649226 - - DataSet_03_386
TXNIP KAT6A CRISPR Haematopoietic_and_lymphoid_tissue MOLM-13 1.56295 0.644271 0.1527657978 0.8388073 DataSet_03_387
TXNIP KDM5A CRISPR Lung GLC16 0.201675 -2.30989 4.710643e-02 0.116612810 DataSet_03_392
TXNIP ILF2 siRNA Stomach SGC-7901 4.04717 2.01691 0.1738729525 0.35365687 DataSet_03_393
TXNIP BMI1 shRNA Bile_duct QBC-939 0.484124 -1.04655 2.327676e-07 0.0003140506 DataSet_03_395
TXNIP HMGA1 shRNA Bile_duct HUCCT1 1.71065 0.774548 2.646978e-02 0.194193010 DataSet_03_400
TXNIP EHF shRNA Stomach MKN7 29.6936 4.89208 - - DataSet_03_402
TXNIP STRAP knockout Nerve SK-N-AS 1.51473 0.599061 - - DataSet_03_409
TXNIP USP22 shRNA Liver HuH7 0.479292 -1.06102 - - DataSet_03_411
TXNIP RUNX2 shRNA Cord_blood Natural Killer Cell 0.324664 -1.62298 2.151439e-03 0.531914435 DataSet_03_416
TXNIP FOXK2 shRNA Ovary OVCAR-5 0.444675 -1.16918 3.048620e-02 0.14162437 DataSet_03_419
TXNIP MAEL CRISPR Liver Alexander cells 0.187107 -2.41807 - - DataSet_03_423
TXNIP FOXP3 CRISPR Peripheral_blood Naive Treg 0.520811 -0.941167 7.060822e-02 0.360169376 DataSet_03_427
TXNIP LHX2 shRNA Bone_marrow ES-derived RPE cells 1.77134 0.824845 1.144344e-01 1.000000e+00 DataSet_03_428
TXNIP USP7 shRNA Skin xenograft cells 0.478465 -1.06351 0.26540200 0.4348960 DataSet_03_431
TXNIP PLAG1 shRNA Cord_blood Lin-CD34+ HSPCs 0.565626 -0.822079 - - DataSet_03_432
TXNIP POU2AF1 CRISPR Haematopoietic_and_lymphoid_tissue OCI-Ly7 1.76584 0.820351 8.326467e-03 0.289074999 DataSet_03_434
TXNIP POU2AF1 CRISPR Lymph SUDHL4 6.58838 2.71992 1.163805e-05 0.005917891 DataSet_03_435
TXNIP SUFU shRNA Mammary_gland HCC1954 cells 6.84701 2.77548 0.0012602324 0.2904148 DataSet_03_437
TXNIP DAXX shRNA Mammary_gland MDA-MB-231 0.275408 -1.86036 6.276790e-04 0.04480740 DataSet_03_441
TXNIP PURA siRNA Cervix HeLa 1.71105 0.774883 6.094830e-03 0.077898593 DataSet_03_444
TXNIP RELB CRISPR Colon SW480 1.58825 0.667434 1.911457e-01 4.100799e-01 DataSet_03_449
TXNIP CBX2 siRNA Mammary_gland MCF7 0.365929 -1.45036 6.824361e-04 0.0043748142 DataSet_03_451
TXNIP SMARCA2 shRNA Lung HCC2302 0.267445 -1.90269 6.540303e-03 9.064353e-03 DataSet_03_455
TXNIP SREBF2 siRNA Umbilical_vein HUVEC 2.12235 1.08566 4.924830e-02 3.578523e-01 DataSet_03_457
TXNIP ARID1A shRNA Bile_duct MMNK1 0.535113 -0.902084 4.362253e-02 0.227885751 DataSet_03_458
TXNIP IRF2 shRNA Cord_Blood CD34+ cells 2.105 1.07382 - - DataSet_03_460
TXNIP SOX9 knockout Liver HuH7 19.4737 4.28345 6.474107e-05 1.683990e-03 DataSet_03_463
TXNIP PARP1 knockout Embryo_kidney HEK293a 1.85233 0.889344 3.981672e-06 4.476839e-05 DataSet_03_464
TXNIP SMARCA1 Cas13 Embryo_kidney HEK293T 2.1749 1.12095 - - DataSet_03_466
TXNIP SMARCA1 CRISPR-Csm Embryo_kidney HEK293T 2.15628 1.10854 - - DataSet_03_467
TXNIP SMARCA1 shRNA Embryo_kidney HEK293T 3.88583 1.95822 - - DataSet_03_468
Regulation Region
 
T(co)Fs that significantly regulate PBX1 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of TXNIP
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines