Gene Overview
Target Gene: DKK1
NCBI Official Symbol: DKK1
Entrez ID: 22943
Ensembl ID: ENSG00000107984
Gene Full Name: dickkopf WNT signaling pathway inhibitor 1
Strand: +
Gene Locus: 10q21.1
External Links:

DKK1 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate DKK1   
T(co)Fs that Repress DKK1
The Intensity of the Gene Regulated by T(co)Fs:
DKK1-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
DKK1 HNF1B shRNA Ovary RMG2 4.12838 2.04558 0.00714 0.01998 DataSet_01_103
DKK1 FOXO1 shRNA Bone EWS-FLI1 0.5155 -0.95596 0.5406 0.95143 DataSet_01_106
DKK1 GABPA siRNA Lung A549 2.50857 1.32686 7.19297e-10 5.68416e-08 DataSet_01_113
DKK1 TCF3 shRNA Mammary_gland MDA-MB468 2.74457 1.45658 0.00023 0.00437 DataSet_01_116
DKK1 FOXM1 siRNA Central_nervous_system U87 6.23946 2.64142 - - DataSet_01_122
DKK1 SOX4 shRNA Parotid_gland ACC3 0.61407 -0.70352 0.1127 0.9541 DataSet_01_140
DKK1 TFAP2C shRNA Mammary_gland MCF7 0.24149 -2.04999 8.74847e-15 8.63356e-13 DataSet_01_150
DKK1 FOSL1 siRNA Mammary_gland BT549 1.63639 0.71051 0.00012 0.0094 DataSet_01_171
DKK1 TP53 siRNA Lung SAECs 0.48997 -1.02923 0.00063 0.12148 DataSet_01_175
DKK1 NR5A2 siRNA Mammary_gland MCF7 0.62699 -0.67348 0.00189 0.02943 DataSet_01_182
DKK1 TP63 shRNA Bladder UC14 1.50694 0.59163 8.24156e-05 0.00133 DataSet_01_183
DKK1 STAT3 siRNA Urothelial Scaber 1.94402 0.95904 2.23814e-08 6.70812e-06 DataSet_01_184
DKK1 GABPA shRNA Prostate C4-2B 1168.37 10.1903 0.23866 0.43934 DataSet_01_190
DKK1 GABPA shRNA Prostate LNCaP 686.282 9.42266 0.4575 0.7048 DataSet_01_191
DKK1 GATA2 siRNA Prostate LNCaP 1.59851 0.67673 0.13541 0.24303 DataSet_01_193
DKK1 CREB1 shRNA Parotid_gland H3118 MEC 0.34239 -1.54628 0.03942 0.29622 DataSet_01_194
DKK1 CREB1 shRNA Parotid_gland HSY 0.62706 -0.67332 0.09023 0.70332 DataSet_01_195
DKK1 TP63 siRNA Immortalized_keratinocyte HaCaT RG 1.82122 0.8649 - - DataSet_01_196
DKK1 XBP1 shRNA Mammary_gland T47D 4.0626 2.0224 2.2049e-07 0.00011 DataSet_01_203
DKK1 HIC1 shRNA Mammary_gland HBL100 0.53937 -0.89065 - - DataSet_01_205
DKK1 MITF shRNA Skin COLO829 1.86731 0.90096 0.20412 0.41336 DataSet_01_207
DKK1 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly10 2.69535 1.43047 - - DataSet_01_208
DKK1 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly1 0.03465 -4.85111 - - DataSet_01_209
DKK1 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly7 0.10432 -3.26093 - - DataSet_01_210
DKK1 LIN28A siRNA Embryo H9 4.11094 2.03947 6.2662e-05 0.00234 DataSet_01_215
DKK1 TAL1 shRNA Haematopoietic_and_lymphoid_tissue HEL 2.59824 1.37753 5.89036e-05 0.00455 DataSet_01_217
DKK1 PTEN shRNA Mammary_gland MCF10A 1.92746 0.9467 1.16099e-08 1.23573e-06 DataSet_01_218
DKK1 ATM shRNA Mammary_gland MCF10A 4.50967 2.17302 7.93372e-06 0.00012 DataSet_01_219
DKK1 KLF9 siRNA Liver HepG2 2.33643 1.2243 2.56351e-08 1.33033e-06 DataSet_01_222
DKK1 FOXM1 siRNA Mammary_gland MCF7 0.41955 -1.25308 0.14534 0.80219 DataSet_01_223
DKK1 HIF1A shRNA Liver HuH7 0.48568 -1.04193 - - DataSet_01_224
DKK1 KLF2 shRNA Bone_marrow RPMI8226 0.56927 -0.81281 0.36617 0.85843 DataSet_01_226
DKK1 MYC siRNA White_adipose_tissue Adipose stem cells 1.69392 0.76036 1.35859e-07 6.20976e-05 DataSet_01_231
DKK1 ARNT shRNA Embryo hESC HSF1 0.33337 -1.58481 0.32637 0.99999 DataSet_01_240
DKK1 GATA6 siRNA Colon HT29 0.40424 -1.30672 - - DataSet_01_247
DKK1 TWIST1 shRNA Stomach CAF14 0.61057 -0.71178 0.33344 0.99996 DataSet_01_252
DKK1 TWIST1 shRNA Stomach CAF32 0.41264 -1.27704 0.00149 0.02223 DataSet_01_253
DKK1 TWIST1 shRNA Stomach CAF 0.50194 -0.99441 0.02322 0.52717 DataSet_01_254
DKK1 YBX1 shRNA Mammary_gland MDA 0.49405 -1.01726 2.55405e-11 1.6753e-09 DataSet_01_259
DKK1 FOXO3 siRNA Pancreas PANC1 0.4732 -1.07949 - - DataSet_01_267
DKK1 OTX2 siRNA Brain Neural precursor cells 0.50537 -0.98459 0.00012 0.16917 DataSet_01_268
DKK1 SIX4 siRNA Ovary PEO1 0.47025 -1.08851 0.00013 0.0041 DataSet_01_269
DKK1 PTEN shRNA Lung A549 3.78736 1.92119 6.76443e-15 1.29755e-10 DataSet_01_276
DKK1 STAT5 shRNA Prostate CWR22Pc 4.2551 2.08919 0.00508 0.03557 DataSet_01_279
DKK1 MSX1 siRNA Tooth Dental Pulp Cells 5.07797 2.34425 6.02691e-07 5.80063e-05 DataSet_01_281
DKK1 ZIC5 siRNA Skin SK-MEL-28 0.14239 -2.81213 - - DataSet_01_285
DKK1 SNAI2 siRNA Mammary_gland MCFDCIS 1.77889 0.83098 0.11346 0.65815 DataSet_01_292
DKK1 POSTN shRNA Brain GSC272 0.09788 -3.35286 0.00238 0.47578 DataSet_01_293
DKK1 TFAP4 siRNA Brain BE(2)-C 0.30497 -1.71328 0.28987 0.51625 DataSet_01_295
DKK1 EP300 siRNA Oesophagus KYSE150 0.59245 -0.75523 - - DataSet_01_297
DKK1 BRD4 siRNA Ovary Ovcar8 0.27984 -1.83731 2.77805e-07 0.00016 DataSet_01_311
DKK1 TFAP2C siRNA Lung NCI-H292 1.84163 0.88098 - - DataSet_01_312
DKK1 OVOL2 siRNA Corneal_epithelial Corneal epithelial cells 0.61724 -0.6961 0.18731 0.40732 DataSet_01_313
DKK1 ARNT siRNA Upper_aerodigestive_tract HSC3 0.32227 -1.63367 - - DataSet_01_315
DKK1 ERG siRNA Cervix HeLa 4.65947 2.22017 4.88814e-13 1.58386e-11 DataSet_01_316
DKK1 ELK3 shRNA Mammary_gland MDA-MB-231 0.01973 -5.66345 7.96383e-09 5.79459e-06 DataSet_01_318
DKK1 STAT3 siRNA Liver LX-2 0.49802 -1.00573 5.48859e-05 0.00068 DataSet_01_334
DKK1 NFE2L2 siRNA Lung A549 2.49751 1.32049 3.69453e-09 1.32463e-06 DataSet_01_335
DKK1 GRHL3 siRNA Skin NHEK 1.83513 0.87588 0.05794 0.48203 DataSet_01_336
DKK1 REST siRNA Skin NHEK 0.60943 -0.71447 0.00267 0.0519 DataSet_01_337
DKK1 KLF4 siRNA Embryo HCE 0.27717 -1.85117 0.00013 0.09365 DataSet_01_341
DKK1 GATA3 siRNA Oral_cavity OEC-M1 0.62789 -0.67141 0.23712 0.99787 DataSet_01_347
DKK1 SOX2 siRNA Embryo Undifferentiated hESCs 3.17771 1.66799 - - DataSet_01_350
DKK1 SMAD3 siRNA Pancreas BxPC-3 0.59416 -0.75108 - - DataSet_01_352
DKK1 CDX2 siRNA Colon COLO320 2.06063 1.04309 - - DataSet_01_357
DKK1 PAX3 shRNA Soft_tissue Rh30 1.52263 0.60656 - - DataSet_01_359
DKK1 SOX17 siRNA Umbilical_vein HUVEC 2.10539 1.07409 - - DataSet_01_360
DKK1 GTF2B siRNA Cervix HeLa 0.47484 -1.07448 - - DataSet_01_362
DKK1 U2AF2 shRNA Liver HepG2 1.73006 0.79082 0.23125 0.37786 DataSet_02_105
DKK1 ZNF622 shRNA Liver HepG2 3.80415 1.92757 5.51912e-05 0.0047 DataSet_02_108
DKK1 GTF2F1 shRNA Liver HepG2 1.65086 0.72321 0.00559 0.21413 DataSet_02_110
DKK1 BCLAF1 shRNA Liver HepG2 0.55341 -0.85359 0.00212 0.02742 DataSet_02_112
DKK1 PCBP1 shRNA Liver HepG2 4.06757 2.02417 0.00017 0.01339 DataSet_02_115
DKK1 TARDBP shRNA Liver HepG2 0.49794 -1.00596 0.00147 0.01782 DataSet_02_116
DKK1 SUB1 shRNA Liver HepG2 0.60942 -0.71449 0.03306 0.17607 DataSet_02_117
DKK1 CEBPZ shRNA Liver HepG2 0.63948 -0.64503 0.81257 1 DataSet_02_118
DKK1 PTBP1 shRNA Liver HepG2 5.65786 2.50026 9.03132e-05 0.00582 DataSet_02_120
DKK1 EWSR1 shRNA Liver HepG2 1.69392 0.76036 0.02451 0.08996 DataSet_02_122
DKK1 PCBP2 shRNA Liver HepG2 2.7365 1.45233 0.00044 0.04878 DataSet_02_123
DKK1 FUS shRNA Liver HepG2 1.60831 0.68554 0.00837 0.08473 DataSet_02_124
DKK1 HNRNPLL shRNA Liver HepG2 0.22317 -2.1638 0.00019 0.01076 DataSet_02_125
DKK1 SRSF3 shRNA Liver HepG2 1.96728 0.9762 0.00297 0.06862 DataSet_02_127
DKK1 AR siRNA Prostate abl cells 1.9899 0.992695 0.0384182890109543 0.999852161656754 DataSet_03_004
DKK1 AR siRNA Prostate LNCaP 0.574683 -0.79916 0.308069557004686 1 DataSet_03_005
DKK1 ARID2 CRISPR Liver JHH4 6.00435 2.58601 0.0449964925672363 1 DataSet_03_015
DKK1 ASCL1 siRNA Lung DMS79 0.55 -0.862496 0.465014053045887 0.904584974080861 DataSet_03_016
DKK1 ATF3 knockout Colon HCT116 0.632798 -0.660182 0.022852752231578 0.809052776016901 DataSet_03_017
DKK1 ATF4 siRNA Skin A375 0.607638 -0.718717 0.236247426813762 0.775512819201899 DataSet_03_018
DKK1 BCL6 siRNA Lymph OCI-Ly7 DLBCL 0.210959 -2.24497 0.0382007045264185 0.688334056096047 DataSet_03_025
DKK1 CASP8AP2 siRNA Bone_marrow U2OS 3.16737 1.66329 3.47316575717525e-06 0.00044141923344273 DataSet_03_031
DKK1 CEBPB siRNA Embryo hESC 0.272974 -1.87316 0.000345630379678235 0.0942819566130977 DataSet_03_049
DKK1 FOXA1 siRNA Mammary_gland MCF7 0.320298 -1.64251 5.3366179575107e-07 4.65730816976017e-05 DataSet_03_080
DKK1 FOXA1 siRNA Mammary_gland MCF7 0.655933 -0.60838 6.74828987541234e-08 1.94101684346648e-06 DataSet_03_081
DKK1 FOXA1 siRNA Mammary_gland MCF7 0.655933 -0.60838 6.74828987541234e-08 1.94101684346648e-06 DataSet_03_082
DKK1 FOXO1 siRNA Skin primary human dermal lymphatic endothelial cells 0.407863 -1.29384 - - DataSet_03_096
DKK1 GATA2 siRNA Uterus Decidual stromal cells 0.298405 -1.74466 0.000244293401247116 0.0944673857858267 DataSet_03_100
DKK1 GATA2 siRNA Lymph Lymphatic endothelial cells 0.632826 -0.66012 0.168598590363848 0.242671746917969 DataSet_03_101
DKK1 GATA6 siRNA Stomach AGS 0.621793 -0.685494 0.00146000643450207 0.137462779735401 DataSet_03_108
DKK1 HIC1 CRISPR Prostate PC3 0.269685 -1.89065 - - DataSet_03_118
DKK1 HINFP siRNA Bone_marrow U2OS 5.04562 2.33503 1.14662795539158e-07 0.000335178461826883 DataSet_03_123
DKK1 HNF4a siRNA Liver HepG2 1.68704 0.754491 0.016624388080636 0.525074233701198 DataSet_03_126
DKK1 JUN siRNA Skin Ma-Mel-15 0.531945 -0.910652 0.105955159384444 0.640830106086979 DataSet_03_143
DKK1 Klf4 siRNA Skin Primary neonatal keratinocytes 0.329735 -1.60062 0.000305768277080947 0.004347611319887 DataSet_03_147
DKK1 KLF5 siRNA Colon SW480 1.87651 0.908051 0.000409097943383983 0.0451356161111189 DataSet_03_148
DKK1 KLF5 siRNA Stomach KatoIII 2.44842 1.29185 9.16183485700559e-05 0.0412114200987988 DataSet_03_150
DKK1 MEF2D shRNA Liver HuH7 0.634131 -0.657146 - - DataSet_03_162
DKK1 MEF2D siRNA Liver HuH7 1.59385 0.672512 - - DataSet_03_163
DKK1 MITF siRNA Skin MZ7 7.35869 2.87945 9.26720949588287e-08 1.88794225631333e-06 DataSet_03_165
DKK1 MITF siRNA Skin Ma-Mel-15 5.26701 2.39698 2.59355973023085e-05 0.0055190314602937 DataSet_03_166
DKK1 MITF siRNA Skin Ma-Mel-15 4.73735 2.24408 0.00148355416605528 0.0398444934758333 DataSet_03_167
DKK1 MITF siRNA Skin SK-MEL-5 1.50398 0.588788 0.0119294983753492 0.0245221759026096 DataSet_03_168
DKK1 MYB siRNA Prostate PC-3M 0.436131 -1.19717 1.2484357681226e-08 7.99969897195891e-06 DataSet_03_173
DKK1 MYC siRNA Colon HT29 1.80705 0.853633 - - DataSet_03_177
DKK1 MYC siRNA Central_nervous_system DAOY M2.1 2.92798 1.5499 7.42588126196069e-06 3.90214653549524e-05 DataSet_03_178
DKK1 NFAT5 siRNA Synovial Primary fibroblast-like synoviocytes 0.441115 -1.18077 0.0871060403279068 0.435037952392937 DataSet_03_194
DKK1 NPAT siRNA Bone_marrow U2OS 3.51296 1.81269 1.48652907565511e-07 0.000510972139133417 DataSet_03_201
DKK1 PRRX1 CRISPR Neuroblastoma 691-MES 1.9312 0.949498 0.497822331016724 0.93029070471583 DataSet_03_217
DKK1 RELB siRNA Immortalized_keratinocyte HaCaT 5.78707 2.53283 5.9650350537369e-07 1.88667406699638e-05 DataSet_03_227
DKK1 SOX11 siRNA Lung_fibroblast NHLF 0.358884 -1.47841 0.0125482237563444 0.308493468732866 DataSet_03_237
DKK1 SOX11 siRNA Lung_fibroblast NHLF 0.475104 -1.07369 0.168207879044242 0.536375619317973 DataSet_03_238
DKK1 SOX2 siRNA Lung H520 2.81294 1.49208 - - DataSet_03_240
DKK1 SOX2 siRNA Lung LK2 3.44347 1.78386 - - DataSet_03_241
DKK1 SOX2 siRNA Embryo 2102Ep 19.3411 4.2736 1.53095058648852e-12 1.1880686868013e-08 DataSet_03_242
DKK1 SOX2 siRNA Embryo NTera-2 6.79833 2.76518 1.34026978264031e-10 1.56014104048245e-06 DataSet_03_243
DKK1 SOX2 CRISPR Seminoma-like TCam-2 2.02325 1.01667 0.0923551451503079 0.999580851453413 DataSet_03_244
DKK1 SOX2 siRNA Mammary_gland GSC-11 0.239352 -2.06279 7.2729537465838e-07 0.00125699112944631 DataSet_03_245
DKK1 SOX4 siRNA Haematopoietic_and_lymphoid_tissue ST1 2.71429 1.44057 - - DataSet_03_246
DKK1 SOX9 knockdown Liver HepG2 3.86708 1.95125 8.86057993655309e-10 5.6241054383948e-06 DataSet_03_248
DKK1 SP1 siRNA Cervix HeLa 7.47565 2.9022 2.88532119662035e-08 2.8400741142188e-05 DataSet_03_249
DKK1 SP1 siRNA Mammary_gland MDA-MB-231 2.78921 1.47986 0.316009687530431 0.52152001305818 DataSet_03_250
DKK1 SP1 siRNA Ovary OVSAYO 2.92086 1.54639 0.110191195512938 0.398200534343095 DataSet_03_251
DKK1 STAT3 CRISPR Embryo hESC 3.53442 1.82147 3.45983849198644e-05 0.00498123677659349 DataSet_03_258
DKK1 STAT3 siRNA Ovary SKOV3 0.646509 -0.629257 2.72833962642104e-06 0.00211170128642353 DataSet_03_261
DKK1 TBX3 siRNA Skin Fibroblast 1.52522 0.609021 0.000276038173036631 0.00973646571194037 DataSet_03_265
DKK1 TFAP2C siRNA Mammary_gland MCF7 0.506877 -0.980291 0.0753190542054219 0.415614944855768 DataSet_03_274
DKK1 TFE3 siRNA Kidney UOK257-2 0.482261 -1.05211 - - DataSet_03_275
DKK1 TP53 siRNA Foreskin Neonatal foreskin keratinocytes 2.13069 1.09132 0.0291041801283258 0.999791649573014 DataSet_03_278
DKK1 TWIST1 siRNA Bone_marrow MSCs 1.52815 0.611786 - - DataSet_03_283
DKK1 ZNF165 siRNA Mammary_gland SUM159 0.540633 -0.887278 0.089415983171962 0.999998167536832 DataSet_03_288
DKK1 ZNF750 siRNA Skin Primary neonatal keratinocytes 0.083726 -3.57818 5.01975663643203e-05 0.0141172506444072 DataSet_03_294
DKK1 CIZ1 CRISPR Liver HepG2 1.68257 0.750665 0.148624128523203 0.383948161893443 DataSet_04_026
DKK1 NFX1 CRISPR Liver HepG2 1.75196 0.808968 0.00824808425035201 0.0324831337561235 DataSet_04_032
DKK1 PAN2 CRISPR Liver HepG2 2.23832 1.16242 0.0128667666771313 0.115733798312293 DataSet_04_033
DKK1 SMAD4 CRISPR Liver HepG2 1.9187 0.94013 0.00258493126991774 0.0692618815275676 DataSet_04_035
DKK1 SMAD5 CRISPR Liver HepG2 1.53937 0.62234 0.141721145471189 0.54034614130994 DataSet_04_036
DKK1 YBX1 CRISPR Liver HepG2 0.342028 -1.54781 0.366913272656642 0.972884761036538 DataSet_04_039
DKK1 ZNF574 CRISPR Liver HepG2 2.15827 1.10987 0.0140353327691801 0.0804791695313299 DataSet_04_041
DKK1 ACTN4 CRISPR Liver HepG2 0.275646 -1.85911 0.0005992257621687 0.0307831735598237 DataSet_04_042
DKK1 CHCHD3 CRISPR Liver HepG2 1.58776 0.666992 0.0427583878452408 0.462359872902174 DataSet_04_067
DKK1 PAN2 CRISPR Liver HepG2 1.9187 0.94013 0.000511076525856031 0.021431285935823 DataSet_04_066
DKK1 CALR shRNA Liver HepG2 0.526982 -0.924174 0.000144771588298721 0.00413295614114027 DataSet_04_053
DKK1 CCAR1 shRNA Liver HepG2 2.35748 1.23724 0.00019114666578536 0.0103075326408406 DataSet_04_054
DKK1 CNOT7 shRNA Liver HepG2 21.7037 4.43987 1.5779704874443e-06 0.000841644333519409 DataSet_04_051
DKK1 PRPF6 shRNA Liver HepG2 3.72424 1.89695 1.85416255010616e-05 0.0210821866264412 DataSet_04_056
DKK1 UBE2L3 shRNA Liver HepG2 0.330554 -1.59704 9.71076128518596e-06 0.00391571396741364 DataSet_04_055
DKK1 EZH2 siRNA Uterus Hec-1A 0.62057 -0.688333 3.245646e-05 2.964988e-03 DataSet_03_314
DKK1 EZH2 shRNA Colon SW480 2.50122 1.32263 - - DataSet_03_298
DKK1 TET1 siRNA Lung A549 1.56883 0.64969 - - DataSet_03_318
DKK1 TET1 siRNA Lung A549 1.56883 0.64969 - - DataSet_03_320
DKK1 EZH2 knockdown Uterus Ishikawa (ISK) cell 0.441352 -1.18 - - DataSet_03_324
DKK1 SMARCA4 siRNA Colon HCT116 1.76094 0.816343 5.957559e-03 0.1306486 DataSet_03_302
DKK1 ELF3 CRISPR Bile_duct HBDEC2 0.634895 -0.655411 2.303193e-04 2.137624e-03 DataSet_03_304
DKK1 SNAI2 shRNA Pancreas pancreatic cancer stem cells 0.408281 -1.29237 5.365158e-03 0.5422587 DataSet_03_306
DKK1 SNAI2 shRNA Pancreas KLM1 1.94895 0.962694 5.538203e-02 0.31977020 DataSet_03_307
DKK1 ACTR5 siRNA Muscle RD 0.391929 -1.35134 - - DataSet_03_343
DKK1 AEBP1 siRNA Central_nervous_system U87MG 2.13521 1.09438 2.351672e-01 0.9999434 DataSet_03_338
DKK1 EZH2 shRNA Mammary_gland MCF7 0.656772 -0.606535 8.518247e-04 2.478474e-02 DataSet_03_331
DKK1 EZH2 knockdown Colon HCT116 0.628653 -0.669665 0.073000909 0.8488990 DataSet_03_334
DKK1 DNMT1 shRNA Lung hTERT-immortalised adult fibroblasts 0.469313 -1.09138 4.747681e-02 4.658987e-01 DataSet_03_311
DKK1 ETV5 knockdown Colon HT29 5.33263 2.41485 9.536146e-03 0.112922682 DataSet_03_353
DKK1 CREBBP CRISPR Brain U5-NPC 1.56714 0.648131 0.4867384439 0.7525833 DataSet_03_356
DKK1 TP53 CRISPR Brain U5-NPC 2.98733 1.57886 1.737395e-02 1.623145e-01 DataSet_03_358
DKK1 NCOA2 siRNA Uterus endometrial stromal cells 0.656853 -0.606356 0.3205674802 1 DataSet_03_360
DKK1 ARID2 shRNA Haematopoietic_and_lymphoid_tissue MM.1S 2.89097 1.53156 2.488802e-07 1.486810e-05 DataSet_03_362
DKK1 ZNF148 shRNA Mammary_gland MDA-MB-231 0.40893 -1.29007 1.076954e-03 0.029552723 DataSet_03_366
DKK1 ABL1 shRNA Liver HuH7 0.526494 -0.925512 9.300336e-07 0.0003774548 DataSet_03_367
DKK1 USP22 shRNA Liver PLC_PRF_5 cells 12.4 3.63227 3.957328e-02 0.19652778 DataSet_03_368
DKK1 DNMT3A knockout Embryo_kidney HEK293T 0.196436 -2.34787 - - DataSet_03_369
DKK1 TPR shRNA Bone_marrow U2OS 2.98558 1.57801 3.853019e-02 2.904782e-01 DataSet_03_370
DKK1 ZFP36L1 siRNA Urinary_bladder J82 1.93363 0.951311 - - DataSet_03_371
DKK1 BHLHE40 shRNA Cervix HeLaS3 1.56268 0.644022 9.930950e-01 0.99941991 DataSet_03_372
DKK1 GLI1 siRNA Skeletal_muscle RMS13 2.51125 1.32841 3.241647e-03 0.039469496 DataSet_03_375
DKK1 NFKB2 siRNA Bone_marrow U2OS 2.76 1.46467 1.495555e-02 0.16791801 DataSet_03_381
DKK1 DNMT1 siRNA Skin Human melanoma cells 1.69257 0.759212 1.542556e-02 3.158119e-02 DataSet_03_382
DKK1 YY1 shRNA Brain GSC1517 0.5 -1 - - DataSet_03_384
DKK1 YY1 shRNA Brain GSC23 0.333333 -1.58496 - - DataSet_03_385
DKK1 KAT6A CRISPR Haematopoietic_and_lymphoid_tissue MOLM-13 0.544175 -0.877857 0.8184603513 0.9682113 DataSet_03_387
DKK1 NFKBIA shRNA Bone_marrow U2OS 0.0420868 -4.57049 9.106617e-01 0.96230123 DataSet_03_389
DKK1 YY1 knockdown Liver HepG2 0.510726 -0.969378 4.660811e-08 1.083638e-06 DataSet_03_390
DKK1 KDM5A CRISPR Lung GLC16 5.40121 2.43328 2.948894e-01 0.450608808 DataSet_03_392
DKK1 ILF2 siRNA Stomach SGC-7901 2.57728 1.36585 0.2217997831 0.40794789 DataSet_03_393
DKK1 ASXL1 CRISPR Embryo iPSC 3.55132 1.82835 0.1634129975 0.8187866 DataSet_03_394
DKK1 RELA CRISPR Brain T30 0.514496 -0.958769 0.0553572898 0.8400824 DataSet_03_399
DKK1 HMGA1 shRNA Bile_duct HUCCT1 1.66697 0.737229 1.081268e-02 0.125817934 DataSet_03_400
DKK1 JARID2 siRNA Adipose_tissue human adipose tissue derived stem cells 1.52267 0.606607 1.716238e-01 0.3785099 DataSet_03_403
DKK1 TFAP2A knockout Embryo H9 0.103082 -3.27814 6.137966e-04 0.02343950 DataSet_03_405
DKK1 STRAP knockout Nerve SK-N-AS 0.406341 -1.29924 - - DataSet_03_409
DKK1 USP22 shRNA Liver HuH7 0.286556 -1.80311 - - DataSet_03_411
DKK1 E2F6 shRNA Liver HuH7 0.314762 -1.66767 - - DataSet_03_412
DKK1 ZKSCAN3 CRISPR Colon HCT116 3.18627 1.67187 1.566723e-01 0.578241551 DataSet_03_415
DKK1 FOXK2 shRNA Ovary OVCAR-5 0.458765 -1.12417 4.138546e-02 0.16331562 DataSet_03_419
DKK1 MAEL CRISPR Liver Alexander cells 0.0789474 -3.66297 - - DataSet_03_423
DKK1 LHX2 shRNA Bone_marrow ES-derived RPE cells 0.574963 -0.79846 3.315630e-01 1.000000e+00 DataSet_03_428
DKK1 USP7 shRNA Skin xenograft cells 0.47838 -1.06377 0.27454014 0.4348960 DataSet_03_431
DKK1 PLAG1 shRNA Cord_blood Lin-CD34+ HSPCs 0.188406 -2.40809 - - DataSet_03_432
DKK1 SUFU shRNA Mammary_gland HCC1954 cells 0.308165 -1.69823 0.2736952998 0.6455297 DataSet_03_437
DKK1 FOXA2 CRISPR Liver iPSCs-derived progenitors and mature hepatocytes 0.610077 -0.712938 9.122309e-01 1.00000000 DataSet_03_439
DKK1 PHF14 siRNA Mammary_gland MDA-MB-231 1.60465 0.682263 0.0289915718 0.3683017 DataSet_03_443
DKK1 FOSL1 siRNA Prostate MSKPCa3 0.49551 -1.01301 0.0144902529 0.3147306 DataSet_03_445
DKK1 RELB CRISPR Colon SW480 0.560129 -0.83617 2.294487e-01 4.613290e-01 DataSet_03_449
DKK1 CBX2 siRNA Mammary_gland MDA-MB-231 0.583089 -0.778213 2.322362e-03 1.653228e-02 DataSet_03_450
DKK1 SMARCA2 shRNA Lung HCC2302 37.6165 5.23329 8.725558e-20 6.185527e-17 DataSet_03_455
DKK1 ARID1A shRNA Bile_duct MMNK1 0.539569 -0.89012 5.125470e-03 0.068560853 DataSet_03_458
DKK1 IRF2 shRNA Cord_Blood CD34+ cells 0.518519 -0.947533 - - DataSet_03_460
DKK1 TXNIP shRNA Cord_Blood CD34+ cells 2.25 1.16992 - - DataSet_03_461
DKK1 SOX9 knockout Liver HuH7 1.6039 0.681583 2.406039e-03 1.595136e-02 DataSet_03_463
DKK1 PARP1 knockout Embryo_kidney HEK293a 1.598 0.676267 1.567895e-04 9.763944e-04 DataSet_03_464
DKK1 STAT3 shRNA Liver HepG2 1.64221 0.715639 2.731777e-02 0.2628484049 DataSet_03_465
DKK1 SMARCA1 CRISPR-Csm Embryo_kidney HEK293T 2.56818 1.36075 - - DataSet_03_467
DKK1 SMARCA1 shRNA Embryo_kidney HEK293T 1.54545 0.628031 - - DataSet_03_468
Regulation Region
 
T(co)Fs that significantly regulate SOX2 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of DKK1
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines