Gene Overview
Target Gene: GDF15
NCBI Official Symbol: GDF15
Entrez ID: 9518
Ensembl ID: ENSG00000130513
Gene Full Name: growth differentiation factor 15
Strand: +
Gene Locus: 19p13.11
External Links:

GDF15 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate GDF15   
T(co)Fs that Repress GDF15
The Intensity of the Gene Regulated by T(co)Fs:
GDF15-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
GDF15 IRF6 shRNA Fetal_liver Primary CD34+ hematopoietic stem/progenitor cells (HSPCs) 2.0636 1.04517 5.2499e-05 0.00396 DataSet_01_101
GDF15 MYB shRNA Fetal_liver Primary CD34+ hematopoietic stem/progenitor cells (HSPCs) 1.97729 0.98352 6.07337e-09 2.62268e-07 DataSet_01_102
GDF15 FOXA1 shRNA Prostate 22RV1 1.6013 0.67924 - - DataSet_01_105
GDF15 FOXO1 shRNA Bone EWS-FLI1 2.01853 1.0133 0.00162 0.07287 DataSet_01_106
GDF15 SPDEF shRNA Mammary_gland MCF7 1.52065 0.60469 0.82373 0.99999 DataSet_01_107
GDF15 ARID1A shRNA Ovary OSE4 0.25374 -1.9786 - - DataSet_01_108
GDF15 ARID1A shRNA Ovary IOSE80pc 0.29825 -1.7454 - - DataSet_01_109
GDF15 HOXA1 siRNA Lung_fibroblast IMR-90 9.53103 3.25263 7.39128e-05 0.01093 DataSet_01_110
GDF15 HSF1 siRNA Upper_aerodigestive_tract HSC3 0.65049 -0.62039 0.06562 0.25818 DataSet_01_112
GDF15 ID1 siRNA Lung A549 1.64648 0.71939 0.0466 0.2341 DataSet_01_117
GDF15 FOXM1 siRNA Central_nervous_system U87 5.53808 2.46939 - - DataSet_01_122
GDF15 ZNF431 siRNA Gastrointestinal_tissue GIST-T1 1.80274 0.85019 8.6582e-05 0.00177 DataSet_01_128
GDF15 ZNF665 siRNA Gastrointestinal_tissue GIST-T1 0.64708 -0.62799 0.00081 0.01374 DataSet_01_129
GDF15 ZNF708 siRNA Gastrointestinal_tissue GIST-T1 0.66517 -0.5882 0.00126 0.02092 DataSet_01_130
GDF15 NFYA shRNA Cervix HeLaS3 1.5416 0.62442 5.49237e-05 0.0032 DataSet_01_131
GDF15 EGR4 siRNA Lung SBC-5 1.82636 0.86897 0.19521 0.58666 DataSet_01_132
GDF15 ID1 shRNA Neuroepithelium GSC2 2.19713 1.13562 1.18907e-11 3.48505e-10 DataSet_01_133
GDF15 SPDEF shRNA Mammary_gland MCF7 1.76375 0.81865 0.00014 0.01633 DataSet_01_135
GDF15 IKZF2 shRNA Haematopoietic_and_lymphoid_tissue JURKAT 3.58741 1.84294 0.00089 0.07003 DataSet_01_137
GDF15 SOX4 shRNA Parotid_gland ACC3 3.0604 1.61372 0.00401 0.83611 DataSet_01_140
GDF15 TEAD4 shRNA Stomach SNU216 0.34749 -1.52497 - - DataSet_01_151
GDF15 HSF1 shRNA Skin A375 1.58441 0.66395 0.11931 0.33508 DataSet_01_155
GDF15 ETV1 shRNA Prostate LNCaP 0.64333 -0.63636 4.29627e-06 7.99365e-05 DataSet_01_161
GDF15 NFATC3 siRNA Peripheral_blood CD4+ T cells 1.85701 0.89298 0.02404 0.15421 DataSet_01_166
GDF15 FOSL1 siRNA Mammary_gland BT549 2.26401 1.17888 4.13258e-09 1.64243e-06 DataSet_01_171
GDF15 ESRRG siRNA Placenta_tissue Trophoblast cells 0.52018 -0.94291 0.00073 0.02813 DataSet_01_173
GDF15 NR4A1 siRNA Pancreas PANC1 2.50244 1.32333 3.57943e-08 3.89314e-05 DataSet_01_174
GDF15 TP53 siRNA Lung SAECs 0.25693 -1.96054 0.0064 0.2244 DataSet_01_175
GDF15 HSF1 shRNA Liver KYN2 3.38942 1.76104 - - DataSet_01_178
GDF15 NR5A2 siRNA Mammary_gland MCF7 1.98386 0.98831 0.00018 0.00563 DataSet_01_182
GDF15 TP63 shRNA Bladder UC14 3.99876 1.99955 1.70592e-07 2.04519e-05 DataSet_01_183
GDF15 STAT3 siRNA Urothelial Scaber 1.60826 0.6855 1.01672e-05 0.00048 DataSet_01_184
GDF15 TCF4 siRNA Autonomic_ganglia SH-SY5Y 2.7092 1.43787 0.00453 0.05923 DataSet_01_185
GDF15 HSF2 siRNA Prostate PC3 1.51126 0.59575 0.82747 0.99991 DataSet_01_187
GDF15 SPDEF siRNA Mammary_gland MCF7 1.81472 0.85975 0.00041 0.05366 DataSet_01_189
GDF15 CREB1 shRNA Parotid_gland H3118 MEC 0.03431 -4.8654 0.07852 0.38656 DataSet_01_194
GDF15 CREB1 shRNA Parotid_gland HSY 0.61846 -0.69325 0.20945 0.88093 DataSet_01_195
GDF15 TP63 siRNA Immortalized_keratinocyte HaCaT RG 0.36426 -1.45695 - - DataSet_01_196
GDF15 TP63 siRNA Head_and_neck SCC-012 0.49697 -1.00878 - - DataSet_01_201
GDF15 TP63 siRNA Head_and_neck SCC-6 0.37079 -1.43134 - - DataSet_01_202
GDF15 XBP1 shRNA Mammary_gland MDA-MB-231 0.55656 -0.84539 0.00037 0.01032 DataSet_01_204
GDF15 ATF2 siRNA Haematopoietic_and_lymphoid_tissue K562 0.46141 -1.11589 0.53386 0.98802 DataSet_01_206
GDF15 LIN28A siRNA Embryo H9 43.8225 5.4536 1.48907e-08 0.00013 DataSet_01_215
GDF15 ATM shRNA Mammary_gland MCF10A 0.17175 -2.54158 0.00023 0.0018 DataSet_01_219
GDF15 KLF3 shRNA Haematopoietic_and_lymphoid_tissue K562 0.66586 -0.5867 1.76227e-06 6.47549e-05 DataSet_01_221
GDF15 FOXM1 siRNA Mammary_gland MCF7 2.32136 1.21497 0.03558 0.52511 DataSet_01_223
GDF15 HIF1A shRNA Liver HuH7 0.36884 -1.43893 - - DataSet_01_224
GDF15 IRX1 shRNA Bone_marrow 143B 2.06479 1.046 0.059 0.25098 DataSet_01_227
GDF15 ESR2 siRNA Mammary_gland BT549 2.15348 1.10667 4.72412e-08 1.16925e-05 DataSet_01_229
GDF15 FOXA1 siRNA Prostate LNCaP 0.53522 -0.9018 0.00529 0.12942 DataSet_01_233
GDF15 FOXP1 siRNA Prostate LNCaP 0.44356 -1.1728 0.00468 0.20791 DataSet_01_234
GDF15 NFYB siRNA Bone_marrow U2OS ER-HA-E2F1 0.5929 -0.75415 0.05276 0.31645 DataSet_01_238
GDF15 STAT5 shRNA Haematopoietic_and_lymphoid_tissue K562 0.38201 -1.38833 1.25207e-05 0.00053 DataSet_01_239
GDF15 TWIST1 shRNA Stomach CAF32 3.31381 1.72849 0.00018 0.01362 DataSet_01_253
GDF15 TWIST1 shRNA Stomach CAF 2.11475 1.08049 0.30063 0.74093 DataSet_01_254
GDF15 YBX1 shRNA Mammary_gland MDA 7.00657 2.80871 2.19577e-05 0.00072 DataSet_01_257
GDF15 YBX1 shRNA Mammary_gland MDA 0.63697 -0.65069 8.61702e-09 2.82082e-07 DataSet_01_259
GDF15 SOX4 shRNA Mammary_gland MDA-MB-231 1.8089 0.85511 0.03163 0.21933 DataSet_01_260
GDF15 MYT1L shRNA Fetal_spinal_cord SPC04 1.79787 0.84629 0.00078 0.0718 DataSet_01_264
GDF15 MEF2A shRNA Fetal_spinal_cord SPC04 0.55784 -0.84208 0.02794 0.89906 DataSet_01_265
GDF15 FOXO1 siRNA Umbilical_vein HUVEC 0.48923 -1.03142 3.37348e-05 0.00448 DataSet_01_270
GDF15 PTEN shRNA Lung A549 1.82856 0.87071 2.59372e-10 3.31685e-07 DataSet_01_276
GDF15 AR shRNA Prostate CWR22Pc 0.5609 -0.83418 0.00131 0.01813 DataSet_01_278
GDF15 STAT5 shRNA Prostate CWR22Pc 0.26594 -1.91082 4.47318e-06 0.00334 DataSet_01_279
GDF15 MSX1 siRNA Tooth Dental Pulp Cells 3.04781 1.60777 3.67181e-05 0.00055 DataSet_01_281
GDF15 AHR siRNA Haematopoietic_and_lymphoid_tissue THP-1 2.62042 1.3898 0.00085 0.00834 DataSet_01_283
GDF15 ZIC5 siRNA Skin A375 5.70793 2.51297 - - DataSet_01_284
GDF15 ZIC5 siRNA Skin SK-MEL-28 1.51932 0.60342 - - DataSet_01_285
GDF15 TP53 shRNA Haematopoietic_and_lymphoid_tissue JVM2 0.28606 -1.80559 2.85031e-05 0.00044 DataSet_01_286
GDF15 NFYA shRNA Lung H322 0.53981 -0.88948 1.51662e-05 0.00058 DataSet_01_288
GDF15 TFAP4 siRNA Brain BE(2)-C 0.22724 -2.13771 0.38241 0.51625 DataSet_01_295
GDF15 SOX17 siRNA Umbilical_vein HUVEC 1.69738 0.76331 0.086 0.99998 DataSet_01_300
GDF15 PTEN shRNA Skin A431 1.60759 0.6849 0.02589 0.13509 DataSet_01_301
GDF15 PTEN shRNA Lung HCC827 0.63042 -0.66562 0.01954 0.48427 DataSet_01_302
GDF15 ETV5 siRNA Soft_tissue hADSC 1.82833 0.87053 9.17508e-05 0.0049 DataSet_01_304
GDF15 SOX9 siRNA Prostate VCaP 0.63828 -0.64774 0.26945 0.93253 DataSet_01_308
GDF15 SOX9 siRNA Prostate VCaP 0.63828 -0.64774 0.26945 0.93253 DataSet_01_309
GDF15 OVOL2 siRNA Corneal_epithelial Corneal epithelial cells 1.60771 0.68501 0.26355 0.48114 DataSet_01_313
GDF15 ARNT siRNA Upper_aerodigestive_tract HSC3 9.14239 3.19257 - - DataSet_01_315
GDF15 ERG siRNA Cervix HeLa 9.68796 3.27619 6.29988e-26 5.75449e-23 DataSet_01_316
GDF15 ELK3 shRNA Mammary_gland MDA-MB-231 0.52706 -0.92397 0.01453 0.03077 DataSet_01_318
GDF15 ZNF25 siRNA Bone_marrow hMSC-TERT4 0.34146 -1.55023 0.00797 0.27643 DataSet_01_319
GDF15 AR shRNA Prostate CWR22Rv1 1.86674 0.90052 5.10026e-05 0.00663 DataSet_01_323
GDF15 TP63 shRNA Head_and_neck FaDU 1.52436 0.60821 0.00011 0.00224 DataSet_01_327
GDF15 TP63 shRNA Head_and_neck FaDU 1.52436 0.60821 0.00011 0.00224 DataSet_01_330
GDF15 HOXC6 siRNA Prostate LNCaP 0.38444 -1.37919 0.01412 0.99927 DataSet_01_333
GDF15 ARID1A shRNA Uterus iEEC16 2.00817 1.00588 - - DataSet_01_345
GDF15 TCF7L1 shRNA Colon HCT116 1.7827 0.83406 9e-04 0.02056 DataSet_01_346
GDF15 SMAD3 siRNA Pancreas BxPC-3 2.00468 1.00337 - - DataSet_01_352
GDF15 ELK1 siRNA Mammary_gland MDA-MB-231 0.62926 -0.66827 - - DataSet_01_354
GDF15 NFYA siRNA Mammary_gland MDA-MB-231 0.53107 -0.91303 - - DataSet_01_355
GDF15 ETV4 shRNA Prostate PC3 3.98795 1.99565 - - DataSet_01_356
GDF15 CDX2 siRNA Colon COLO320 2.12814 1.08959 - - DataSet_01_357
GDF15 PAX3 shRNA Soft_tissue Rh30 2.14016 1.09772 - - DataSet_01_359
GDF15 GTF2B siRNA Cervix HeLa 3.36899 1.75232 - - DataSet_01_362
GDF15 RBFOX2 shRNA Liver HepG2 2.03529 1.02524 0.1701 0.65981 DataSet_02_101
GDF15 FIP1L1 shRNA Liver HepG2 2.2899 1.19528 0.00397 0.02638 DataSet_02_103
GDF15 U2AF2 shRNA Liver HepG2 2.39757 1.26157 0.08662 0.20012 DataSet_02_105
GDF15 TAF15 shRNA Liver HepG2 0.48555 -1.04232 0.00869 0.02765 DataSet_02_106
GDF15 SSB shRNA Liver HepG2 0.13198 -2.92163 8.68012e-05 0.00367 DataSet_02_107
GDF15 ZNF622 shRNA Liver HepG2 2.43345 1.283 0.00072 0.00762 DataSet_02_108
GDF15 HNRNPUL1 shRNA Liver HepG2 1.64988 0.72236 0.01192 0.04517 DataSet_02_109
GDF15 U2AF2 shRNA Liver HepG2 2.53346 1.34111 0.00683 0.06309 DataSet_02_113
GDF15 XRCC5 shRNA Liver HepG2 1.60587 0.68336 0.05527 0.21752 DataSet_02_114
GDF15 TARDBP shRNA Liver HepG2 1.85484 0.8913 0.02843 0.0696 DataSet_02_116
GDF15 RBM25 shRNA Liver HepG2 1.81251 0.85799 0.03893 0.08929 DataSet_02_119
GDF15 PCBP2 shRNA Liver HepG2 1.70348 0.76848 0.02609 0.118 DataSet_02_123
GDF15 SNRNP70 shRNA Liver HepG2 3.04526 1.60657 0.00599 0.04313 DataSet_02_126
GDF15 SRSF3 shRNA Liver HepG2 1.95518 0.9673 0.03077 0.12529 DataSet_02_127
GDF15 TARDBP shRNA Haematopoietic_and_lymphoid_tissue K562 2.01868 1.01342 0.00352 0.24543 DataSet_02_129
GDF15 PTBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 2.0362 1.02588 0.00159 0.02792 DataSet_02_131
GDF15 AGO2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.13426 -2.89689 8.43925e-05 0.08861 DataSet_02_132
GDF15 SRSF9 shRNA Haematopoietic_and_lymphoid_tissue K562 1.75049 0.80776 0.00103 0.0884 DataSet_02_134
GDF15 TAF15 shRNA Haematopoietic_and_lymphoid_tissue K562 0.34208 -1.54761 0.00025 0.13508 DataSet_02_140
GDF15 RBM34 shRNA Haematopoietic_and_lymphoid_tissue K562 1.92059 0.94155 0.08762 0.29198 DataSet_02_141
GDF15 BCLAF1 shRNA Haematopoietic_and_lymphoid_tissue K562 2.04604 1.03283 0.00035 0.08476 DataSet_02_142
GDF15 RBM15 shRNA Haematopoietic_and_lymphoid_tissue K562 1.55787 0.63958 0.05442 0.10498 DataSet_02_143
GDF15 PTBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 2.88522 1.52868 0.00054 0.19727 DataSet_02_144
GDF15 FIP1L1 shRNA Haematopoietic_and_lymphoid_tissue K562 2.3237 1.21642 0.02183 0.10946 DataSet_02_147
GDF15 ILF3 shRNA Haematopoietic_and_lymphoid_tissue K562 0.54571 -0.8738 0.07877 0.3523 DataSet_02_148
GDF15 NONO shRNA Haematopoietic_and_lymphoid_tissue K562 2.09691 1.06826 0.03654 0.21559 DataSet_02_149
GDF15 SAFB2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.58968 -0.762 0.00702 0.41496 DataSet_02_150
GDF15 ILF2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.6427 -0.63778 0.06998 0.34288 DataSet_02_152
GDF15 HNRNPUL1 shRNA Haematopoietic_and_lymphoid_tissue K562 1.79248 0.84196 0.03486 0.51515 DataSet_02_156
GDF15 PSIP1 shRNA Haematopoietic_and_lymphoid_tissue K562 1.81386 0.85906 0.03763 0.12539 DataSet_02_158
GDF15 HNRNPL shRNA Haematopoietic_and_lymphoid_tissue K562 0.60414 -0.72705 0.02377 0.14639 DataSet_02_160
GDF15 SUB1 shRNA Haematopoietic_and_lymphoid_tissue K562 1.68339 0.75137 0.08196 0.71289 DataSet_02_161
GDF15 AGO1 shRNA Haematopoietic_and_lymphoid_tissue K562 1.7319 0.79235 0.10047 0.5986 DataSet_02_162
GDF15 TAF15 shRNA Haematopoietic_and_lymphoid_tissue K562 0.21983 -2.18557 0.02171 0.26948 DataSet_02_163
GDF15 SSB shRNA Haematopoietic_and_lymphoid_tissue K562 1.54207 0.62487 0.06998 0.26448 DataSet_02_164
GDF15 EWSR1 shRNA Haematopoietic_and_lymphoid_tissue K562 1.58563 0.66506 0.05379 0.2564 DataSet_02_167
GDF15 TARDBP shRNA Haematopoietic_and_lymphoid_tissue K562 0.54544 -0.87452 0.00158 0.04354 DataSet_02_169
GDF15 ZFX siRNA Prostate C4-2B 3.99081 1.99668 7.04732e-06 0.00065 DataSet_02_172
GDF15 RAD21 siRNA Haematopoietic_and_lymphoid_tissue K562 0.57722 -0.7928 0.84221 1 DataSet_02_190
GDF15 CHD2 siRNA Haematopoietic_and_lymphoid_tissue K562 1.54202 0.62482 0.54407 0.64584 DataSet_02_196
GDF15 TAL1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.60717 -0.71982 0.78698 1 DataSet_02_201
GDF15 ZFX siRNA Mammary_gland MCF7 1.78026 0.83209 0.00701 0.07352 DataSet_02_206
GDF15 AR siRNA Prostate abl cells 0.36004 -1.47377 0.00880290068142783 0.877408447909779 DataSet_03_004
GDF15 AR siRNA Prostate LNCaP 0.453712 -1.14015 0.0783779625279566 1 DataSet_03_005
GDF15 AR siRNA Prostate CWR22Rv1 1.62375 0.699333 0.0126429661107036 0.395186913606655 DataSet_03_008
GDF15 ASCL1 siRNA Lung DMS79 0.522901 -0.935391 0.146748795927311 0.810683683797745 DataSet_03_016
GDF15 BCL6 siRNA Central_nervous_system U87 1.87271 0.905127 0.00169292217898983 0.0828409620280298 DataSet_03_027
GDF15 CASP8AP2 siRNA Bone_marrow hTERT-RPE1 30.7739 4.94363 2.21570125768852e-10 3.88611843585989e-07 DataSet_03_030
GDF15 CASP8AP2 siRNA Bone_marrow U2OS 3.42706 1.77697 0.00545164855465424 0.0599100651629578 DataSet_03_031
GDF15 E2F7 siRNA Upper_aerodigestive_tract SCC25 1.78876 0.838957 3.9222434860717e-05 0.000543055720760627 DataSet_03_063
GDF15 FOXA1 siRNA Mammary_gland MCF7 0.601606 -0.733109 1.23661102522656e-07 3.26386077001444e-06 DataSet_03_081
GDF15 FOXA1 siRNA Mammary_gland MCF7 0.601606 -0.733109 1.23661102522656e-07 3.26386077001444e-06 DataSet_03_082
GDF15 FOXA1 siRNA Prostate LNCaP 0.425443 -1.23296 2.81547494738177e-11 2.50448227715223e-08 DataSet_03_083
GDF15 FOXM1 siRNA Aorta Vascular smooth muscle cells 1.71908 0.781641 - - DataSet_03_090
GDF15 GATA2 siRNA Lymph Lymphatic endothelial cells 2.99589 1.58299 0.0261811079235288 0.0517029360408774 DataSet_03_101
GDF15 GATA3 siRNA Mammary_gland MCF7 9.10537 3.18672 0.140646442134339 0.287686281290409 DataSet_03_103
GDF15 GATA4 siRNA Stomach AGS 0.59647 -0.745479 0.123321512235235 0.776090481678004 DataSet_03_105
GDF15 GFP siRNA Upper_aerodigestive_tract SCC25 1.5035 0.588323 1.16491684591296e-05 0.000473076559490474 DataSet_03_112
GDF15 GRHL3 siRNA Skin Primary neonatal keratinocytes 0.498997 -1.0029 0.196598772789341 0.457389458714431 DataSet_03_113
GDF15 HES6 siRNA Brain A172 1.86413 0.898505 0.0010651616892247 0.838538233201032 DataSet_03_116
GDF15 HES6 siRNA Brain LN405 1.7004 0.765873 0.0149014860737603 0.959972868676594 DataSet_03_117
GDF15 HINFP siRNA Bone_marrow hTERT-RPE1 12.4543 3.63858 4.89634908788281e-07 0.00214692666630942 DataSet_03_122
GDF15 HINFP siRNA Bone_marrow U2OS 2.26236 1.17783 9.34641682343221e-06 0.00381225127130645 DataSet_03_123
GDF15 HMGA2 siRNA Mammary_gland MDA-MB-231 0.428037 -1.22419 0.0153662634259903 0.624469235714366 DataSet_03_125
GDF15 HNF4a siRNA Liver HepG2 1.74193 0.800688 0.217232189608649 0.811062597581946 DataSet_03_126
GDF15 IRF4 siRNA Skin Cutaneous T cell lymphoma HuT-102 cells 1.68919 0.756335 0.569477210847611 0.999948959532916 DataSet_03_134
GDF15 KDM3A siRNA Mammary_gland MCF7 0.243091 -2.04043 4.38243092121333e-08 0.000116956967985058 DataSet_03_146
GDF15 Klf4 siRNA Skin Primary neonatal keratinocytes 0.380491 -1.39406 2.40857609136717e-05 0.00100890249928606 DataSet_03_147
GDF15 KLF5 siRNA Stomach YCC3 1.7227 0.784673 0.0756575574143086 0.393932292812419 DataSet_03_151
GDF15 MEF2D shRNA Liver HuH7 1.95002 0.963489 - - DataSet_03_162
GDF15 MEF2D siRNA Liver HuH7 7.48838 2.90465 - - DataSet_03_163
GDF15 MITF siRNA Skin MZ7 0.310018 -1.68957 5.68156383964842e-13 6.04650846174117e-11 DataSet_03_165
GDF15 MITF siRNA Skin Ma-Mel-15 0.179519 -2.4778 2.73303044125354e-05 0.00559371670427498 DataSet_03_166
GDF15 MITF siRNA Skin Ma-Mel-15 0.280907 -1.83184 0.00131223079550456 0.0367361076455779 DataSet_03_167
GDF15 MITF siRNA Skin SK-MEL-5 0.579204 -0.787856 0.000673596553616669 0.00246963788419758 DataSet_03_168
GDF15 MTA2 siRNA Stomach SGC-7901 1.58315 0.662799 - - DataSet_03_169
GDF15 MYB siRNA Cord_Blood CD34+ progenitor cells 3.95064 1.98209 - - DataSet_03_170
GDF15 MYB siRNA Prostate PC-3M 1.58337 0.663 0.000135644695861401 0.00379352741096109 DataSet_03_173
GDF15 MYB siRNA Prostate VCaP 0.185351 -2.43167 1.63835687068176e-07 0.000708630305491628 DataSet_03_174
GDF15 MYC siRNA Central_nervous_system DAOY M2.1 2.34085 1.22703 2.904283703837e-07 3.26713057696573e-06 DataSet_03_178
GDF15 MYCN CRISPR Neuroblastoma CHP-134 142.859 7.15845 1.36046917990473e-16 4.36438512913437e-12 DataSet_03_183
GDF15 MYCN CRISPR Neuroblastoma CHP-134 142.859 7.15845 1.36046917990473e-16 4.36438512913437e-12 DataSet_03_184
GDF15 MYCN siRNA Brain BE(2)C cells 2.01796 1.0129 - - DataSet_03_188
GDF15 NFAT5 siRNA Synovial Primary fibroblast-like synoviocytes 6.84361 2.77476 2.57339004694768e-05 0.0155622348595744 DataSet_03_194
GDF15 NPAT siRNA Bone_marrow hTERT-RPE1 62.9489 5.97611 2.72080824813247e-10 4.77202558639954e-06 DataSet_03_200
GDF15 NPAT siRNA Bone_marrow U2OS 1.57467 0.655052 0.000188950951160546 0.0108966697574673 DataSet_03_201
GDF15 PBX1 siRNA Mammary_gland MCF7 0.490599 -1.02738 3.0815237437473e-06 0.00127923387655177 DataSet_03_209
GDF15 PHB shRNA Embryo Embryonic stem cells (ESCs) 33.3815 5.06098 7.40926635097851e-06 0.000318574770350918 DataSet_03_211
GDF15 PRRX1 siRNA Skin Fibroblast 1.73308 0.793335 0.00183762414717676 0.169456431934432 DataSet_03_216
GDF15 PRRX1 CRISPR Neuroblastoma 691-MES 0.436312 -1.19657 0.0465221102407045 0.89189998148014 DataSet_03_217
GDF15 RARA siRNA Mammary_gland MCF7 1.51351 0.597896 0.0241012742792184 0.280727961981518 DataSet_03_218
GDF15 RELB siRNA Immortalized_keratinocyte HaCaT 14.2579 3.83369 3.0579722410382e-11 7.83792262847435e-09 DataSet_03_227
GDF15 SOX11 siRNA Lung_fibroblast NHLF 1.62206 0.697831 0.0226532672898054 0.247229219188386 DataSet_03_238
GDF15 SOX2 siRNA Lung H520 2.4065 1.26693 - - DataSet_03_240
GDF15 SOX2 siRNA Mammary_gland GSC-11 0.463384 -1.10972 5.16576510881332e-05 0.00517667760608395 DataSet_03_245
GDF15 SOX4 siRNA Haematopoietic_and_lymphoid_tissue ST1 1.64444 0.7176 - - DataSet_03_246
GDF15 SOX9 knockdown Liver HepG2 0.513047 -0.962837 8.4949419357048e-07 0.000207385492743193 DataSet_03_248
GDF15 SP1 siRNA Mammary_gland MDA-MB-231 1.71458 0.777853 0.446068256515001 0.631289784072949 DataSet_03_250
GDF15 STAT1 knockout Liver Huh-7.5 2.23225 1.1585 0.00156200166262705 0.0433685167505863 DataSet_03_257
GDF15 STAT3 CRISPR Embryo hESC 0.174933 -2.51513 0.00537905828394766 0.0505468108267712 DataSet_03_258
GDF15 TBX3 siRNA Skin Fibroblast 1.78875 0.838954 5.53747334411144e-06 0.000622102768353715 DataSet_03_265
GDF15 TET2 siRNA Embryo NCCIT 1.72784 0.78897 0.000960248405332438 0.00834159880100005 DataSet_03_270
GDF15 TET2 siRNA Prostate DU145 1.50339 0.58822 - - DataSet_03_271
GDF15 TET3 siRNA Embryo NCCIT 1.53561 0.61881 0.00271902694302643 0.0233089461582605 DataSet_03_273
GDF15 TFAP2C siRNA Mammary_gland MCF7 1.80223 0.849783 0.0234999865886318 0.323654763910558 DataSet_03_274
GDF15 TFE3 siRNA Kidney UOK257-2 0.648537 -0.62474 - - DataSet_03_275
GDF15 TP53 knockout Haematopoietic_and_lymphoid_tissue MM1S 0.110263 -3.18098 0.0231337217473149 0.994828053448528 DataSet_03_279
GDF15 TP53 knockout Haematopoietic_and_lymphoid_tissue MOLP8 0.158198 -2.6602 0.0999801875727286 0.749037002844151 DataSet_03_280
GDF15 TP63 siRNA Foreskin Neonatal foreskin keratinocytes 0.365374 -1.45255 0.147446427775463 0.746518568529322 DataSet_03_282
GDF15 TWIST1 siRNA Bone_marrow MSCs 5.74713 2.52284 - - DataSet_03_283
GDF15 TWIST2 siRNA Skin Fibroblast 1.65686 0.728453 3.36621630643164e-05 0.00665587523629415 DataSet_03_284
GDF15 ZNF165 siRNA Mammary_gland WHIM12 1.93528 0.952546 0.106538337461703 0.999997668745677 DataSet_03_289
GDF15 ZNF746 siRNA Colon HCT116 0.596668 -0.745 - - DataSet_03_293
GDF15 APTX CRISPR Haematopoietic_and_lymphoid_tissue K562 2.11582 1.08122 0.135660330178994 0.651571729851862 DataSet_04_001
GDF15 CDC5L CRISPR Haematopoietic_and_lymphoid_tissue K562 1.81492 0.859905 0.0042361007581608 0.0492904083765691 DataSet_04_002
GDF15 CIZ1 CRISPR Haematopoietic_and_lymphoid_tissue K562 2.58134 1.36812 0.00677440307505567 0.0342430781639935 DataSet_04_004
GDF15 MARK2 shRNA Haematopoietic_and_lymphoid_tissue K562 2.29843 1.20065 0.0196131201273598 0.0459330889821857 DataSet_04_012
GDF15 NKRF shRNA Haematopoietic_and_lymphoid_tissue K562 0.3358 -1.57433 0.0486007544500171 0.134722619776771 DataSet_04_014
GDF15 NUP35 shRNA Haematopoietic_and_lymphoid_tissue K562 2.8377 1.50472 0.00425357953951221 0.0208163818122466 DataSet_04_015
GDF15 RPS3 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.624361 -0.679548 0.0908719812239804 0.485351134526356 DataSet_04_017
GDF15 SMAD2 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.517928 -0.949177 0.00259965589577314 0.0786343354168621 DataSet_04_018
GDF15 SMAD4 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.490979 -1.02627 0.00574230061550242 0.103798470787339 DataSet_04_019
GDF15 XRCC5 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.651929 -0.617213 0.0012844863981497 0.138162568200977 DataSet_04_021
GDF15 E4F1 CRISPR Liver HepG2 1.65152 0.723796 0.0117898026022384 0.232181015080061 DataSet_04_028
GDF15 CNOT7 CRISPR Liver HepG2 0.601067 -0.734402 5.46087229503912e-05 0.00988884057427267 DataSet_04_045
GDF15 SEPT11 CRISPR Liver HepG2 0.502806 -0.991925 0.000900831112673329 0.0373208249143754 DataSet_04_068
GDF15 ABT1 shRNA Liver HepG2 2.61517 1.3869 0.00073129076105724 0.0069596977454207 DataSet_04_052
GDF15 CALR shRNA Liver HepG2 1.77538 0.828124 0.00414081468933946 0.0215492070641529 DataSet_04_053
GDF15 NPM1 shRNA Liver HepG2 0.646052 -0.630277 0.604470487279053 0.907366210034925 DataSet_04_058
GDF15 PRPF6 shRNA Liver HepG2 0.596651 -0.745041 0.0121924800247152 0.0836546859688337 DataSet_04_056
GDF15 UBE2L3 shRNA Liver HepG2 2.70512 1.43569 0.000171688334227412 0.00653129992892012 DataSet_04_055
GDF15 DPF2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 1.77184 0.825245 0.00015539198791158 0.0068705144852399 DataSet_02_14
GDF15 LDB1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.605316 -0.72424 0.000729096990161262 0.0139168235891329 DataSet_02_35
GDF15 NFE2L1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.596123 -0.746319 0.0600054689876272 0.386893706726647 DataSet_02_32
GDF15 SMARCA4 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.639954 -0.64396 0.000541555226924921 0.0107671158727209 DataSet_02_47
GDF15 SNW1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 1.98646 0.990199 0.0603862465846108 0.44301343631786 DataSet_02_49
GDF15 ABT1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.666157 -0.586065 0.00182668358061747 0.0261131854243802 DataSet_04_060
GDF15 HDGF shRNA Haematopoietic_and_lymphoid_tissue K562 1.73822 0.797611 0.0104036158597777 0.0306640053934646 DataSet_04_059
GDF15 PRPF6 shRNA Haematopoietic_and_lymphoid_tissue K562 0.23368 -2.09739 0.00202439694592801 0.211850822379596 DataSet_04_065
GDF15 MBD5 siRNA Bile_duct HCCC-9810 0.410751 -1.28366 4.201304e-08 0.0004071522 DataSet_03_295
GDF15 CNOT3 shRNA Lung A549 1.63473 0.709053 1.513466e-01 0.8830540 DataSet_03_340
GDF15 DNMT1 siRNA Lung_fibroblast IMR-90 1.56926 0.650088 4.686595e-01 0.9999458 DataSet_03_317
GDF15 TET1 siRNA Lung A549 3.46272 1.7919 - - DataSet_03_318
GDF15 TET1 siRNA Lung A549 3.46272 1.7919 - - DataSet_03_320
GDF15 NFKBIZ knockout Colon Colon organoid 0.519628 -0.944448 1.071118e-03 0.290289877 DataSet_03_323
GDF15 ZNF598 knockout Cervix HeLa 2.50522 1.32494 5.052708e-02 1.0000000 DataSet_03_299
GDF15 EZH2 knockdown Uterus Ishikawa (ISK) cell 1.74755 0.805333 - - DataSet_03_324
GDF15 NSD2 shRNA Haematopoietic_and_lymphoid_tissue K562 3.74865 1.90637 1.479678e-10 3.230874e-07 DataSet_03_303
GDF15 ELF3 knockdown Bile_duct HBDEC2 0.613265 -0.705417 5.806293e-04 1.586566e-02 DataSet_03_305
GDF15 HDAC5 siRNA Liver human hepatocytes 0.483398 -1.04872 8.314374e-08 2.595356e-05 DataSet_03_346
GDF15 SNAI2 shRNA Pancreas pancreatic cancer stem cells 0.645523 -0.63146 1.179192e-01 0.6510154 DataSet_03_306
GDF15 INO80 siRNA Muscle RD 3.37019 1.75283 - - DataSet_03_344
GDF15 PBX1 siRNA Mammary_gland MCF7 0.490598 -1.02739 4.017920e-06 1.410703e-03 DataSet_03_326
GDF15 BRCA1 siRNA Mammary_gland MCF7 1.91676 0.938667 3.805621e-03 0.7228344 DataSet_03_308
GDF15 EZH2 shRNA Mammary_gland MCF7 0.487541 -1.0364 3.616474e-04 1.358389e-02 DataSet_03_331
GDF15 EZH2 knockdown Colon HCT116 0.567981 -0.816085 0.118788437 0.8488990 DataSet_03_334
GDF15 DNMT1 shRNA Lung hTERT-immortalised adult fibroblasts 3.87618 1.95464 2.058096e-01 7.397431e-01 DataSet_03_311
GDF15 TET1 CRISPR Mammary_gland MDA-MB-231 75.8144 6.2444 4.773937e-02 1.657708e-01 DataSet_03_347
GDF15 ZFX siRNA Prostate C4-2B 4.20441 2.0719 8.284048e-08 1.628387e-05 DataSet_03_348
GDF15 ZFX siRNA Mammary_gland MCF7 1.82209 0.865595 2.026277e-04 5.252857e-03 DataSet_03_349
GDF15 SKI CRISPR Blood HL60 76 6.24793 6.362318e-03 0.152837123 DataSet_03_351
GDF15 ESR1 siRNA Mammary_gland MCF7 1.72693 0.788213 2.709100e-02 0.1267178691 DataSet_03_352
GDF15 ETV5 knockdown Colon HT29 3.00231 1.58607 1.715734e-04 0.027802643 DataSet_03_353
GDF15 CREBBP CRISPR Brain U5-NPC 1.57377 0.654225 0.8424913836 0.9050721 DataSet_03_356
GDF15 TP53 CRISPR Brain U5-NPC 0.0573771 -4.12338 6.769047e-03 1.623145e-01 DataSet_03_358
GDF15 ARID2 shRNA Haematopoietic_and_lymphoid_tissue MM.1S 6.2409 2.64175 8.195530e-05 4.997384e-04 DataSet_03_362
GDF15 MYC siRNA Peripheral_blood T lymphocyte 2.75859 1.46393 3.588340e-03 0.041924878 DataSet_03_363
GDF15 TP53 knockout Stomach SNU1 0.00139834 -9.48207 0.0680791922 0.9301241 DataSet_03_365
GDF15 ZNF148 shRNA Mammary_gland MDA-MB-231 0.30119 -1.73125 3.147495e-04 0.020123630 DataSet_03_366
GDF15 ABL1 shRNA Liver HuH7 0.628769 -0.669398 1.464560e-04 0.0019388461 DataSet_03_367
GDF15 DNMT3A knockout Embryo_kidney HEK293T 1.54288 0.62563 - - DataSet_03_369
GDF15 ZFP36L1 siRNA Urinary_bladder J82 5.72057 2.51616 - - DataSet_03_371
GDF15 BHLHE40 shRNA Cervix HeLaS3 4.18121 2.06392 1.273564e-01 0.84447131 DataSet_03_372
GDF15 HNRNPU siRNA Colon RKO 0.398821 -1.32619 - - DataSet_03_374
GDF15 GLI1 siRNA Skeletal_muscle RMS13 4.6153 2.20643 1.421453e-05 0.003302909 DataSet_03_375
GDF15 EZH2 CRISPR Ovary SKOV3 4.85542 2.2796 1.008994e-04 0.0055966138 DataSet_03_378
GDF15 DDX5 shRNA Stomach HGC-27 58.97 5.88191 - - DataSet_03_379
GDF15 TCF19 CRISPR Oral_squamous CAL27 2.35209 1.23394 9.747349e-05 0.0062142025 DataSet_03_383
GDF15 YY1 shRNA Brain GSC1517 2.31526 1.21117 - - DataSet_03_384
GDF15 YY1 shRNA Brain GSC23 1.81944 0.863498 - - DataSet_03_385
GDF15 YY1 shRNA Brain GSC3028 0.660714 -0.597902 - - DataSet_03_386
GDF15 KAT6A CRISPR Haematopoietic_and_lymphoid_tissue MOLM-13 2.06962 1.04936 0.3510121270 0.8482378 DataSet_03_387
GDF15 TRIM8 siRNA Mammary_gland MCF7 1.96762 0.97645 1.496938e-02 0.0684012125 DataSet_03_388
GDF15 YY1 knockdown Liver HepG2 3.17596 1.66719 2.297004e-14 7.959120e-12 DataSet_03_390
GDF15 PRDM15 CRISPR Kidney Immortalized human podocytes 0.328676 -1.60526 5.975913e-06 3.154144e-04 DataSet_03_391
GDF15 KDM5A CRISPR Lung GLC16 0.0438385 -4.51166 2.617533e-04 0.012073084 DataSet_03_392
GDF15 ASXL1 CRISPR Embryo iPSC 1.5769 0.657089 0.1638585999 0.8187866 DataSet_03_394
GDF15 IKZF2 CRISPR Lymph CAR T Cell 0.574577 -0.799429 2.840699e-01 0.753482753 DataSet_03_397
GDF15 TLE4 CRISPR Lymph CAR T Cell 0.499042 -1.00277 1.101806e-01 0.37764110 DataSet_03_398
GDF15 HMGA1 shRNA Bile_duct HUCCT1 4.43415 2.14866 4.077302e-04 0.025269353 DataSet_03_400
GDF15 EHF shRNA Stomach MKN7 0.00121438 -9.68556 - - DataSet_03_402
GDF15 JARID2 siRNA Adipose_tissue human adipose tissue derived stem cells 1.88129 0.911726 2.327247e-01 0.4357996 DataSet_03_403
GDF15 CDK7 shRNA Bone_marrow D458 9.46855 3.24314 1.457634e-04 0.04089447 DataSet_03_404
GDF15 MAP3K7 shRNA Prostate LNCaP 0.332913 -1.58678 1.956520e-06 3.329140e-04 DataSet_03_408
GDF15 STRAP knockout Nerve SK-N-AS 3.76401 1.91227 - - DataSet_03_409
GDF15 SIRT1 siRNA Pancreas PANC1 0.422858 -1.24175 4.063196e-05 0.008076714 DataSet_03_410
GDF15 USP22 shRNA Liver HuH7 1.7035 0.768497 - - DataSet_03_411
GDF15 E2F2 siRNA Prostate LNCaP 4.24391 2.08539 1.037828e-06 3.442414e-04 DataSet_03_414
GDF15 RUNX2 shRNA Cord_blood Natural Killer Cell 4.9 2.29278 3.999836e-03 0.648809686 DataSet_03_416
GDF15 NFATC2 shRNA Haematopoietic_and_lymphoid_tissue THP-1 3.46104 1.79121 1.372001e-01 0.316432580 DataSet_03_418
GDF15 FOXK2 shRNA Ovary OVCAR-5 0.0740674 -3.75502 7.099785e-04 0.08266460 DataSet_03_419
GDF15 BRD4 CRISPR Lymph CD8+ T cells 3 1.58496 - - DataSet_03_420
GDF15 MAEL CRISPR Liver Alexander cells 0.1067 -3.22836 - - DataSet_03_423
GDF15 STAT5B CRISPR Embryo_kidney HEK293 0.5 -1 4.320706e-01 0.764657930 DataSet_03_424
GDF15 FOXP3 CRISPR Peripheral_blood Naive Treg 2 1 5.164118e-01 0.790177835 DataSet_03_427
GDF15 IKZF2 shRNA Lymph Hut78 3.34614 1.7425 6.701705e-03 0.40530138 DataSet_03_429
GDF15 USP7 shRNA Skin xenograft cells 0.431666 -1.21201 0.26771787 0.4348960 DataSet_03_431
GDF15 PLAG1 shRNA Cord_blood Lin-CD34+ HSPCs 0.48951 -1.03059 - - DataSet_03_432
GDF15 POU2AF1 CRISPR Haematopoietic_and_lymphoid_tissue OCI-Ly7 3.33333 1.73697 1.264384e-01 0.500930674 DataSet_03_434
GDF15 CIC knockout Brain Immortalized Astrocyte Cells 5.74377 2.522 3.569658e-01 7.709610e-01 DataSet_03_438
GDF15 FOXA2 CRISPR Liver iPSCs-derived progenitors and mature hepatocytes 2.15849 1.11002 7.265994e-02 0.90558273 DataSet_03_439
GDF15 SETDB1 shRNA Colon HCT116 3.78756 1.92127 - - DataSet_03_440
GDF15 DAXX shRNA Mammary_gland MDA-MB-231 0.0916476 -3.44776 3.880674e-04 0.03913699 DataSet_03_441
GDF15 HMG20A siRNA Mammary_gland MDA-MB-231 1.88391 0.913726 0.1586210047 0.4177179 DataSet_03_442
GDF15 PHF14 siRNA Mammary_gland MDA-MB-231 2.03694 1.0264 0.0104802119 0.2772439 DataSet_03_443
GDF15 FOSL1 siRNA Prostate MSKPCa3 1.67129 0.740961 0.0907549027 0.4830782 DataSet_03_445
GDF15 CAMTA1 knockout Embryo_kidney HEK293T 0.461538 -1.11548 1.426367e-01 0.32307174 DataSet_03_448
GDF15 RELB CRISPR Colon SW480 0.522879 -0.935452 6.037098e-03 5.898641e-02 DataSet_03_449
GDF15 CBX2 siRNA Mammary_gland MCF7 0.297065 -1.75115 2.506545e-02 0.0627261121 DataSet_03_451
GDF15 ZFP36L1 CRISPR Lung NCI-H1876 2.18992 1.13088 2.655916e-01 0.992381486 DataSet_03_454
GDF15 PPARG siRNA Aortic_valve Valvular endothelial cell 1.55278 0.634851 7.477411e-02 4.226625e-01 DataSet_03_456
GDF15 SREBF2 siRNA Umbilical_vein HUVEC 0.429189 -1.22031 3.173619e-05 7.078917e-03 DataSet_03_457
GDF15 ARID1A shRNA Bile_duct MMNK1 1.57357 0.654044 2.010478e-02 0.145387032 DataSet_03_458
GDF15 IRF2 shRNA Cord_Blood CD34+ cells 1.75568 0.812031 - - DataSet_03_460
GDF15 TXNIP shRNA Cord_blood ST3 7.66667 2.9386 7.644536e-04 0.0511010968 DataSet_03_462
GDF15 SOX9 knockout Liver HuH7 0.366482 -1.44819 5.120003e-05 1.477030e-03 DataSet_03_463
GDF15 PARP1 knockout Embryo_kidney HEK293a 3.56563 1.83416 9.107084e-11 6.786437e-09 DataSet_03_464
GDF15 STAT3 shRNA Liver HepG2 3.7314 1.89972 2.341189e-04 0.0176150678 DataSet_03_465
GDF15 SMARCA1 Cas13 Embryo_kidney HEK293T 29.3476 4.87517 - - DataSet_03_466
GDF15 SMARCA1 CRISPR-Csm Embryo_kidney HEK293T 12.3598 3.62758 - - DataSet_03_467
GDF15 SMARCA1 shRNA Embryo_kidney HEK293T 3.29268 1.71926 - - DataSet_03_468
GDF15 LIN28A siRNA Mammary_gland MCF7M 1.58724 0.66652 3.960333e-01 0.7578894 DataSet_03_469
GDF15 LIN28A siRNA Mammary_gland MCF7M 1.58724 0.66652 3.960333e-01 0.7578894 DataSet_03_470
GDF15 WHSC1 siRNA Prostate PC3 0.383358 -1.38323 5.162421e-02 0.21113332 DataSet_03_471
GDF15 EZH2 siRNA Prostate LNCaP 0.472338 -1.08211 - - DataSet_03_472
GDF15 APTX CRISPR Haematopoietic_and_lymphoid_tissue K562 2.11582 1.08122 0.1035016 0.5323019 DataSet_04_072
GDF15 CDC5L CRISPR Haematopoietic_and_lymphoid_tissue K562 1.81492 0.859905 0.0008435568 0.013927733 DataSet_04_074
Regulation Region
 
T(co)Fs that significantly regulate PBX1 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of GDF15
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines